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Complexes of germanium with amino acids and carboxylic acids and method for preparing same

A technology of amino acids and coordination compounds, applied in germanium organic compounds, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as complex methods

Active Publication Date: 2014-12-10
WDS PHARM LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] ● Not only the use of potassium hydroxide and sodium hydroxide to convert germanium dioxide into a soluble form by the formation of potassium or sodium metagermanate complicates the process, but the process also leads to the presence of alkali metal cations in the final product, which is Undesirable in the pharmacological application of the resulting compound;

Method used

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  • Complexes of germanium with amino acids and carboxylic acids and method for preparing same
  • Complexes of germanium with amino acids and carboxylic acids and method for preparing same
  • Complexes of germanium with amino acids and carboxylic acids and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Add 3.12g (0.03mol) α-germanium dioxide GeO to a round bottom flask equipped with a stirrer and a thermometer 2, 5.22g (0.03mol) arginine HN=C (NH 2 )NH(CH 2 ) 3 CH(NH 2 ) COOH and 150 mL distilled water. The suspension was stirred under heating (at 85-95° C.) for 2 hours. The resulting clear solution was cooled, filtered and the water was removed on a rotary evaporator. The product was obtained as 8.4 g (94%) of a white amorphous powder. The IR and NMR spectra of the product compounds are shown in Figures 1a and 1b. Elemental analysis data are presented in Table 1. Elemental analysis and spectral data showed that the product was equivalent to compound (II).

Embodiment 2

[0067] Add 3.12g (0.03mol) α-germanium dioxide GeO to a round bottom flask equipped with a stirrer and a thermometer 2 , 9.84g (0.06mol) lysine monohydrate H 2 N(CH 2 ) 4 CH(NH 2 )COOH·H 2 O and 200 mL of distilled water. The suspension was stirred with heating (at 85-95° C.) for 2 hours until a clear solution formed. The resulting clear solution was then cooled, filtered and the water removed using a rotary evaporator. The product was obtained as 11.4 g (96%) of a white amorphous powder. The IR and NMR spectra of the product compounds are shown in Figures 2a and 2b. Elemental analysis data are presented in Table 1. Elemental analysis and spectral data showed that the product was equivalent to compound (III).

Embodiment 3

[0069] Add 3.12g (0.03mol) α-germanium dioxide GeO to a round bottom flask equipped with a stirrer and a thermometer 2 , 10.71g (0.09mol) threonine CH 3 CH(OH)CH(NH 2 )COOH and 300mL distilled water. The suspension was stirred with heating (at 90-100° C.) for 2 hours until a clear solution formed. The resulting clear solution was then cooled, filtered and the water removed using a rotary evaporator. The product was obtained as 12.4 g (97%) of a white amorphous powder. The IR and NMR spectra of the product compounds are shown in Figures 3a and 3b. Elemental analysis data are presented in Table 1. Elemental analysis and spectroscopic data showed that the product was equivalent to compound (IV).

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Abstract

The invention relates to complex compounds of germanium with amino acids and carboxylic acids of the general formula Ge[OH] a [AA] b [CA] c (I), where AA is an amino acid, CA is a carboxylic acid, a = 0-3, b = 1-3, c = 0-3, and 1<b+c<4, wherein AA and CA in the complex can be identical or different, and to a method for preparing the same. The method consists in preparing an aqueous suspension of germanium dioxide, adding an amino acid and a carboxylic acid to the aqueous suspension of germanium oxide produced, heating the mixture produced with agitation at a temperature of 40-100°C for 2-14 hours with subsequent filtering, removal of the water and production of a complex in solid form. The method makes it possible to prepare stable complex compounds with a controllable composition and a controllable ratio of germanium to amino acid and carboxylic acid which are stable in solid form and can be used in medicine.

Description

field of invention [0001] The invention relates to a new germanium coordination compound formed from germanium, amino acid and carboxylic acid and a preparation method thereof. [0002] More specifically, the present invention relates to the preparation method of the germanium coordination compound formed by germanium of formula (I), amino acid and carboxylic acid, [0003] Ge[OH] a [AA] b [CA] c (I) [0004] The method involves reacting an aqueous solution of an amino acid or a mixture of an amino acid and a carboxylic acid with germanium dioxide. The germanium complexes thus produced can be used in different fields of engineering, preferably medicine. Background technique [0005] Compounds containing germanium are widely used in different fields of science and engineering, such as semiconductors and catalysts for the production of polyesters and polyolefins, for the preparation of optical fibers for telecommunication facilities and lenses and eyeglasses for IR s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F7/30A61K31/28A61K33/24
CPCC07F7/30A61K31/555A61K33/24C07F7/003A61P17/00A61P17/10A61P31/04A61K31/28A61K35/74C07C219/06
Inventor A·D·伊萨耶夫T·O·曼纳舍罗夫I·V·安波罗索夫S·K·马特洛
Owner WDS PHARM LLC
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