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Preparation method of CdTe quantum dots for fluorescence detection of aspirin

A technology for aspirin and fluorescence detection, applied in the direction of fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of high limitations, cumbersome operation, and high price, and achieve wide detection range, high accuracy, and short detection time short effect

Inactive Publication Date: 2014-12-10
JIANGSU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims at the shortcomings of the current aspirin detection method, such as high limitation, cumbersome operation and high price, and aims to provide a CdTe quantum dot for fluorescent detection of aspirin and its preparation method , the MSA-modified CdTe QDs prepared by the method of the present invention have good optical properties and have the ability to detect aspirin content

Method used

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  • Preparation method of CdTe quantum dots for fluorescence detection of aspirin
  • Preparation method of CdTe quantum dots for fluorescence detection of aspirin
  • Preparation method of CdTe quantum dots for fluorescence detection of aspirin

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Experimental program
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Effect test

Embodiment 1

[0025] Add 30.3 mg sodium borohydride and 51.04 mg tellurium powder to the 2 Add 2 mL of distilled water to the centrifuge tube drained of oxygen, seal it quickly, and use a needle to discharge the generated H 2 , sonicated for 1 h until the solution turned pale pink, and the final liquid was the desired precursor NaHTe.

[0026] Inject the newly obtained precursor NaHTe into the CdCl in the presence of thiomalic acid (MSA) at a pH of 10.5 with nitrogen and deoxygenation 2 In aqueous solution, the CdCl added 2 2.5H 2 The masses of O and MSA are 182.688 mg and 300.3 mg, respectively. Mixed solution under nitrogen protection 100 o C under reflux reaction to obtain green quantum dots.

Embodiment 2

[0028] 60.6 mg sodium borohydride (NaBH 4 ) and 51.04 mg tellurium powder was added to the already used N 2 Add 2 mL of distilled water to the centrifuge tube drained of oxygen, seal it quickly, and use a needle to discharge the generated H 2 , sonicated for 1 h until the solution turned pale pink, and the final liquid was the desired precursor NaHTe.

[0029] Inject the newly obtained precursor NaHTe into the CdCl in the presence of thiomalic acid (MSA) at pH 11.5 with nitrogen and deoxygenation 2 In aqueous solution, the CdCl added 2 2.5H 2 The masses of O and MSA are 456.72 mg and 450.45 mg, respectively. Mixed solution under nitrogen protection 100 o C under reflux reaction to obtain green quantum dots.

Embodiment 3

[0031] 45 mg sodium borohydride (NaBH 4 ) and 51.04 mg tellurium powder was added to the already used N 2 Add 2 mL of distilled water to the centrifuge tube drained of oxygen, seal it quickly, and use a needle to discharge the generated H 2 , sonicated for 1 h until the solution turned pale pink, and the final liquid was the desired precursor NaHTe.

[0032] Inject the newly obtained precursor NaHTe into the CdCl in the presence of thiomalic acid (MSA) at a pH of 11.2 2 In aqueous solution, the CdCl added 2 2.5H 2 The masses of O and MSA are 365.376 mg and 375.375 mg, respectively. Mixed solution under nitrogen protection 100 o C under reflux reaction to obtain green quantum dots.

[0033] figure 1 It is a comparison graph of the fluorescence wavelengths of MSA-CdTe QDs and TGA-CdTe QDs under different reaction time conditions. When the reaction time is 45 minutes, the wavelength of MSA-CdTe QDs is 545 nm (curve b), when the reaction time is 6 hours, the wavelength of...

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Abstract

The invention relates to a preparation method of CdTe quantum dots for the fluorescence detection of aspirin, which belongs to the technical field of material preparation and drug content detection. According to the technical scheme of the invention, the method comprises the steps of mixing cadmium chloride (CdCl2.2.5H2O) and thiomalic acid (MSA) into an aqueous solution with a certain pH; mixing NaBH4 and Te powder and carrying out ultrasonic reaction on the obtained mixture so as to obtain a NaHTe solution; mixing the two solutions; and carrying out reflux reaction to generate MSA-modified CdTe quantum dots. CdTeQDs obtained by using the method disclosed by the invention have good optical properties and an capability of rapidly detecting the aspirin content; compared with traditional high performance liquid, ultraviolet, raman detection methods and the like, the method for the fluorescence detection of aspirin by CdTeQDs can achieve the effects of short detection time, high detection sensitivity and accuracy, and wide detection range.

Description

technical field [0001] The invention relates to a preparation method of CdTe quantum dots for fluorescent detection of aspirin, belonging to the technical fields of material preparation and drug content detection. Background technique [0002] Aspirin is an antipyretic and analgesic with a long history, which was born on March 6, 1899. It is used to treat colds, fever, headache, toothache, arthralgia, rheumatism, and can also inhibit platelet aggregation. It is used to prevent and treat ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. It is used in angioplasty and side effects Road grafts are also effective. However, excessive aspirin also has a serious impact on the mechanism of the human body. Therefore, it is particularly important to accurately detect the content of aspirin. At present, the detection methods for aspirin content mainly include: high performance liquid chromatography, ultraviolet spectrophotometry, Raman spec...

Claims

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Application Information

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IPC IPC(8): C09K11/88C09K11/02G01N21/64
Inventor 卫潇李洪吉徐叶青高林王吉祥郑旭东周志平闫永胜
Owner JIANGSU UNIV
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