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Application of baohuoside I in preparation of medicines for preventing and treating alzheimer disease

A technology of Alzheimer's disease and baojoside, which is applied in the field of pharmacy, can solve the problems of many adverse reactions and unsatisfactory curative effects, and achieve good therapeutic effect, reduce the formation of senile plaques, and reduce neuroinflammation.

Inactive Publication Date: 2014-12-03
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have a certain effect in improving the clinical symptoms of patients, but their widespread use is limited to a certain extent due to the existence of many adverse reactions or unsatisfactory curative effects, so it is extremely important to seek new treatment methods

Method used

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  • Application of baohuoside I in preparation of medicines for preventing and treating alzheimer disease
  • Application of baohuoside I in preparation of medicines for preventing and treating alzheimer disease
  • Application of baohuoside I in preparation of medicines for preventing and treating alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 of the present invention: take baojoside I 5 g, medicinal starch 75 g, and microcrystalline cellulose 20 g, dry the medicinal starch first, and then mix with baojoside I and microcrystalline cellulose after passing through a 120 mesh sieve , cross 120 mesh sieve twice, fill in the hard capsule, make 1000 capsules of the present invention. Each hard capsule contains 0.5 mg of the main ingredient.

Embodiment 2

[0038] Embodiment 2 of the present invention: get baojoside I 5g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, magnesium stearate 1g; After fully mixing, put it into a high-speed blender, spray with an appropriate amount of water, granulate, control the water content at 3-4%, and then compress into tablets to make 1000 tablets, coated with film.

Embodiment 3

[0039] Embodiment 3 of the present invention: Take 5 g of baojoside I, add 400 ml of polyethylene glycol 200 to dissolve, then add an appropriate amount of distilled water for dilution, then add an appropriate amount of sucrose and adjust the volume to 1000 ml, stir well, filter, and fill Into 10 ml or 20 ml each, sterilized packaging.

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Abstract

The invention discloses an application of baohuoside I in preparation of medicines for preventing and treating alzheimer disease. The baohuoside I is adopted for preparing medicines for treating the alzheimer disease. A series of animal experiments verify that the prepared medicinal composition is capable of preventing and treating learning and memory decline due to the alzheimer disease, reducing formation of characteristic pathologic changed senile plaque due to the alzheimer disease and relieving neuroinflammation response in attack of alzheimer disease. The material in the application is wide in source and easily available, is used for easily and feasibly preparing medicines, and has a good treatment effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the use of baojoside I in the preparation of drugs for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a common degenerative disease of the central nervous system in the elderly. The onset of the disease is insidious, and the main manifestations are progressive memory loss and cognitive dysfunction. Epidemiological surveys show that the prevalence of Alzheimer's disease accounts for about 10% of the elderly over 60 years old, and the incidence is increasing year by year. It is the main type of dementia in the elderly, accounting for 60% of the total incidence of dementia. %-70%. The pathogenesis of Alzheimer's disease has not yet been elucidated, and it may involve gene mutations, mitochondrial dysfunction, neuroinflammation, cholinergic defects, and environmental toxins. Among them, β-amyloid (Aβ) is currently believed to be Neuro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/28
Inventor 龚其海邓媛媛石京山李菲
Owner ZUNYI MEDICAL UNIVERSITY
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