Preparation method and product of ultrathin high strength hydrogel membrane

A high-strength, hydrogel technology, which is applied in the field of preparation of hydrogel films, can solve the problems of complex preparation process and inability to reuse hydrogel films, and achieve the effect of simple preparation method, low cost and easy synthesis

Active Publication Date: 2014-11-19
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process is relatively complicated, and the chemically crosslinked hydrogel film cannot be reused through gel-sol transition.

Method used

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  • Preparation method and product of ultrathin high strength hydrogel membrane
  • Preparation method and product of ultrathin high strength hydrogel membrane
  • Preparation method and product of ultrathin high strength hydrogel membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Take a random copolymer hydrogel film containing 10% stearyl acrylate as an example:

[0054] (1) Prepare an ethanol solution containing 2.7 mol / L acrylic acid monomer, 0.3 mol / L stearyl acrylate (SA) and 0.03 mol / L azobisisobutyronitrile (the total monomer concentration is 3 mol / L). Azobisisobutyronitrile (AIBN) was used as a thermal initiator, and the polymerization reaction was carried out in the absence of oxygen at 60°C for 10 hours to obtain a transparent and viscous ethanol solution of acrylic acid-octadecyl acrylate random copolymer.

[0055] (2) Configure ethanol / water mixed solvent containing 5% volume content in a watch glass as film-forming liquid, draw acrylic acid-stearyl acrylate random copolymer ethanol solution and drop 3 drops into ethanol / water mixed solvent with a dropper middle. The random copolymer solution spread rapidly on the surface of ethanol / water mixed solvent, and formed a physical hydrogel film after solvent exchange.

[0056] (3) The hy...

Embodiment 2

[0061] Take a random copolymer hydrogel film containing 5% stearyl acrylate as an example:

[0062] (1) Prepare an ethanol solution containing 2.85 mol / L acrylic acid monomer, 0.15 mol / L octadecyl acrylate and 0.03 mol / L azobisisobutyronitrile (the total monomer concentration is 3 mol / L). AIBN was used as a thermal initiator, and the polymerization reaction was carried out in the absence of oxygen at 60°C for 10 hours to obtain a transparent and viscous ethanol solution of acrylic acid-stearyl acrylate random copolymer.

[0063] (2) Configure ethanol / water mixed solvent containing 2% volume content in a watch glass as a film-forming liquid, use a dropper to draw acrylic acid-stearyl acrylate random copolymer ethanol solution and drop 3 drops into the ethanol / water mixed solvent middle. The random copolymer solution spread rapidly on the surface of ethanol / water mixed solvent, and formed a physical hydrogel film after solvent exchange.

[0064] The hydrogel film prepared in t...

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Abstract

The invention discloses a preparation method of an ultrathin high strength hydrogel membrane. The preparation method comprises the steps of mixing a hydrophilic monomer, a hydrophobic monomer, an initiator and a solvent A to obtain a mixed liquor, and performing free radical polymerization to obtain a random copolymer solution; and dripping the random copolymer solution into a solvent B, spreading on the surface of the solvent B to form an ultrathin high strength hydrogel membrane, wherein the solvent A is a single solvent or a mixed solvent capable of simultaneously dissolving the hydrophilic monomer, the hydrophobic monomer and the random copolymer, the solvent B is a poor solvent of the random copolymer and is a single solvent or a mixed solvent, and the solvent A and solvent B are much different in surface tension. The hydrogel membrane prepared by the method has the thickness of 10-200mu m, has good mechanical property, can be converted into sol and has repairable function under stimulation of pH, temperature and solvent, and can be used in the fields of medical wound dressing, separating membrane materials, facial mask base materials.

Description

technical field [0001] The invention relates to the field of preparation of hydrogel films, in particular to a preparation method of ultra-thin high-strength hydrogel films and products thereof. Background technique [0002] Hydrogel is a typical soft material, which consists of a three-dimensional network formed by chemical or physical cross-linking between molecules and a large amount of aqueous medium dispersed in it. Due to the soft and wet structure similar to biological soft tissue, small molecules can freely diffuse among them, and various responsiveness, hydrogel has a wide range of applications in drug release, artificial organs, soft actuators and other fields. [0003] The Chinese patent document with the publication number CN101982202B discloses a medical hydrogel dressing and a preparation method thereof. The guanidinium salt polycondensate is an antibacterial agent, which is prepared by adding a cross-linking agent and reacting at 40-80°C. However, compared w...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J3/075C08F220/18
Inventor 吴子良杨红梅吴佳春郑强
Owner ZHEJIANG UNIV
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