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Preparation method of organic/inorganic composite porous scaffold material for bone tissue engineering

A tissue engineering and inorganic composite technology, applied in the field of biomedical materials, to achieve the effects of convenient adjustment, uniform pore distribution, and low toxicity

Inactive Publication Date: 2014-11-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to solve the degradation rate and the problem of pore size of composite support material, propose a kind of preparation method of poly-alpha-hydroxy acid / bioactive ceramic composite porous support material, the composite material pore size and the degradation rate of composite material made by the present invention The speed meets the requirements of bone tissue engineering

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  • Preparation method of organic/inorganic composite porous scaffold material for bone tissue engineering

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Experimental program
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Embodiment 1

[0025] Dissolve 2.0 g of poly-L-lactic acid in 20.0 ml of 1,4-dioxane at room temperature. 2.0 g of hydroxyapatite was ultrasonically dispersed in the same volume of 1,4-dioxane for 1 hour, then added to the polylactic acid solution and stirred for 30 minutes. Add 32g of ground sodium chloride powder with a particle size of 80-100 mesh into the above mixed solution and continue stirring. The mixture was cast and dried under natural conditions for 24 hours. The prepared material was soaked in deionized water to remove sodium chloride therefrom. Finally at 40 o C dried under vacuum for 24 hours to obtain poly-L-lactic acid / hydroxyapatite porous composite scaffold material. The scanning electron microscope photo of the cross-section of the scaffold material is attached figure 1 , it can be seen that the prepared composite porous scaffold material has uniform pores and pore sizes, the porosity of the scaffold material is 80%, the pore size is 150-250 μm, and the degradation ti...

Embodiment 2

[0027] 2.0 g of polylactic acid was dissolved in 20.0 ml of 1,4-dioxane at room temperature, and 7.0 g of bioactive glass was ultrasonically dispersed in the same volume of 1,4-dioxane. Then mix the two solutions and stir well. Add 64 g of sieved 60-80 mesh porogen sodium chloride fine powder into the mixed solution, and continue stirring until the solution and the porogen are completely mixed evenly. The mixture was cast and dried under natural conditions for 12 hours. The dried samples were then soaked in a beaker of deionized water to remove the porogen sodium chloride. Change the water every 12 hours and detect with silver nitrate solution until there is no residual Cl in the soaking solution - . Finally, place the sample at 45 o C under vacuum for 48 hours to obtain the polylactic acid / bioactive glass porous composite material. The scaffold material has a porosity of 90%, a pore size of 200-250 μm, and a degradation time of 110 days.

Embodiment 3

[0029] 2.0 g of lactic acid-glycolic acid copolymer was dissolved in 20.0 ml of 1,4-dioxane at room temperature. 0.86 g of hydroxyapatite was dissolved in 1,4-dioxane and dispersed ultrasonically for 1 hour, then added to the lactic acid-glycolic acid copolymer solution and stirred on a magnetic stirrer for 30 min. Add the ground sodium chloride powder with a particle size of 80-100 mesh to the above mixture and continue stirring for 30 min. The mixture was cast in Petri dishes and dried under natural conditions for 24 hours. The prepared material was soaked in deionized water to remove NaCl therein, and the water was changed every 12 hours for at least 4 soaks. Finally at 45 o C dried under vacuum for 72 hours to obtain the lactic acid-glycolic acid copolymer / hydroxyapatite porous composite material. The scaffold material has a porosity of 85%, a pore size of 150-250 μm, and a degradation time of 120 days.

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Abstract

The invention belongs to the field of biomedical materials, and relates to a technology using an organic / inorganic composite porous scaffold material in the bone tissue engineering. The organic / inorganic composite porous scaffold material is prepared through the following steps: dissolving alpha-hydroxy acid (such as polycaprolactone, polylactic acid, polyglycolic acid, and lactic acid-glycolic acid copolymer) by a low-toxicity organic solvent 1,4-dioxane, dispersing bioactive ceramic (such as bioactive glass, hydroxyapatite, carbonated hydroxyapatite and tricalcium phosphate) by the same solvent, mixing the above obtained solutions, adding a water-soluble salt (such as sodium chloride, sodium bicarbonate and disodium hydrogen phosphate) as a pore forming agent, casting to a die having a certain shape, allowing the solvent to naturally volatilize, removing the pore forming agent through a simple water washing process, and carrying out vacuum drying to finally prepare the porous scaffold material. A preparation method of the porous scaffold material has the advantages of simple and easy operation, mild preparation conditions and good reappearance. The composite porous scaffold material prepared through the preparation method is expected to be applied in the bone tissue engineering in order to carry out bone restoration and substitution.

Description

technical field [0001] The technical field of the present invention belongs to the field of biomedical materials, and it is a technology of using organic / inorganic composite porous scaffold materials for bone tissue engineering, and specifically relates to a type of bone tissue engineering based on poly-alpha-hydroxy acid and bioactive ceramics. Preparation method of porous scaffold material. Background technique [0002] Every year, millions of people suffer from disease or accidental injury, suffer from tissue damage and repair, and many of them die while waiting for a transplantable organ. This shortage of organs has led the medical community to continue to explore, and to alleviate the problem through new medical methods such as relative organ transplantation and adult tissue culture, but the problem of insufficient donors still exists. In addition, possible problems such as bacterial infection and rejection caused by allogeneic transplantation will also bring great pai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08L67/04C08K3/40C08K3/32A61L27/18A61L27/10A61L27/56
Inventor 张普敦王倩姜小婷
Owner BEIJING UNIV OF CHEM TECH
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