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Self-contained two-dimensional code anti-fake medicine, and preparation method and identification method thereof

A two-dimensional code and drug technology, which is applied in the fields of pharmaceutical formulations, drug delivery, and devices that make drugs into special physical or taking forms, can solve the problems of single anti-counterfeiting technical means, slow identification process and high cost, and achieve identification Simple operation, safety guarantee, avoid imitation effect

Active Publication Date: 2014-10-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to realize a self-loaded two-dimensional code anti-counterfeit medicine and its preparation and identification method, which is used to solve the problems of single anti-counterfeiting technical means of traditional medicine, easy imitation, high cost, and slow identification process.

Method used

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  • Self-contained two-dimensional code anti-fake medicine, and preparation method and identification method thereof
  • Self-contained two-dimensional code anti-fake medicine, and preparation method and identification method thereof
  • Self-contained two-dimensional code anti-fake medicine, and preparation method and identification method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1, preparing a self-loaded two-dimensional code anti-counterfeiting drug loaded with 2% hyaluronic acid.

[0046] The specific preparation method is as follows:

[0047] Firstly, generate a 2mm×2mm QR code with the message “2% hyaluronic acid” through the QR code generator v1.0, and then use CAD drawing software to convert the QR code into C02 for laser micro-processing The laser engraving machine can recognize the Dxf format and generate drawings under corel draw12. Set the power parameter to 4.9, the pace parameter to 6, and perform etching under the Job control platform. Put a piece of polymethyl methacrylate substrate with a size of 10mm×10mm and a thickness of 2mm, process the two-dimensional code structure on the substrate, and obtain a base plate with a two-dimensional code structure with a size of 2mm×2mm. Then pour 1 ml of the prepared polydimethylsiloxane liquid into the polymethyl methacrylate bottom plate, and vacuum it at room temperature for more...

Embodiment 2

[0048] Example 2, preparation of self-loaded two-dimensional code structure drug loaded with 1.5% gelatin.

[0049] The specific preparation method is as follows:

[0050] Firstly, generate a 1mm×1mm 2D code with the information of "1.5% gelatin" through the v1. in the computer. Put a silicon chip with a size of 5mm×5mm and a thickness of 1mm, process the two-dimensional code structure on the bottom plate, and obtain a solid bottom plate with a two-dimensional code structure with a size of 2mm×2mm. Then pour 1ml of the prepared polydimethylsiloxane liquid into the polymethyl methacrylate bottom plate, and vacuum it at room temperature under the pressure of -0.05MPa for more than 60min until there are no bubbles in the polydimethylsiloxane Put the polydimethylsiloxane that has exhausted the air bubbles into a vacuum drying oven, take it out after baking at a temperature of 100°C for 100 minutes, and obtain a solid mold prepared by medicine; put 1 milliliter of 15% polyethylen...

Embodiment 3

[0051] Example 3, identifying self-loaded two-dimensional code structure drugs loaded with 1.5% gelatin.

[0052] The specific identification method is as follows:

[0053] Place the self-loaded two-dimensional code of the above-mentioned medicines in a well-lit place to capture images, and call the core functions graythresh, medfilt2, and imdilste in the MATLAB compilation environment to realize threshold segmentation, median filtering, and image expansion operations respectively, and get processed The final image is recognized by an infrared camera. If the recognition is successful, a drug information window will pop up.

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Abstract

The invention provides a self-contained two-dimensional code anti-fake medicine, and a preparation method and an identification method thereof, and belongs to the technical field of biological medicine preparation. According to the preparation method, a micro-processing technology is adopted to perform two-dimension code structure processing on a substrate, the polydimethylsiloxane is adopted to perform antagonizing model on a base plate with the two-dimension code structure to obtain a solid mould for preparing the medicine, the polyvinyl alcohol with the molecular weight of 80,000 to 120,000 is poured into the mould to form a medicine-contained coating, then a medicine solution is poured, and drying is carried out to obtain the self-contained two-dimensional code medicine. The self-contained two-dimensional code medicine provided by the invention can be applied to the anti-fake field of medicines, and has the advantages that firstly, the medicine can directly carry anti-fake information per se to avoid a re-imitation problem of printed paper labels; secondly, the influence of the traditional radio frequency identification (RFID) technology on safety and effectiveness of electronic tags is avoided; finally, an anti-fake process of the medicine and an identification process of the medicine are further simplified, thereby being rapid and low in cost.

Description

technical field [0001] The invention relates to a self-loaded two-dimensional code anti-counterfeit medicine and a preparation and identification method thereof, belonging to the technical field of biomedicine preparation. Background technique [0002] Nowadays, drug anti-counterfeiting has become an indispensable and important part in the field of medicine, and it is a social public undertaking related to everyone's health and national economy and people's livelihood. [0003] In the process of fighting wits and courage with counterfeiters, the anti-counterfeiting technology of pharmaceutical packaging is also constantly improving. According to different materials, the anti-counterfeiting technology on the medicine box can be divided into: laser anti-counterfeiting technology (laser lamination, positioning laser hot stamping non-positioning laser hot stamping, true color laser photopolymer), anti-counterfeiting ink (thermochromic ink, light Changing ink, etc.), watermark a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/20A61J3/00A61J3/07G06K19/06G06K7/10
Inventor 刘冉费捷
Owner TSINGHUA UNIV
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