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Magnetic iron-oxide nanoparticle covering method using silicon dioxide

A magnetic iron oxide and nanoparticle technology, which is applied in the fields of magnetism of inorganic materials, manufacturing of inductors/transformers/magnets, electrical components, etc., can solve problems such as cumbersome operation process and limited application in the field of biomedicine, and achieve simple process and difficult spontaneous formation Good effect of nucleus, size uniformity and shape controllability

Inactive Publication Date: 2014-10-01
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the operation process of this method is very cumbersome, and a large amount of surfactants and organic solutions harmful to human health and the environment are introduced into the reaction system, which is difficult to completely remove from the product, which limits the application in the field of biomedicine

Method used

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  • Magnetic iron-oxide nanoparticle covering method using silicon dioxide
  • Magnetic iron-oxide nanoparticle covering method using silicon dioxide
  • Magnetic iron-oxide nanoparticle covering method using silicon dioxide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 2mmol of iron acetylacetonate and 25mL of triethylene glycol into a three-necked flask and mix thoroughly. After passing through nitrogen for 2 minutes, heat and stir, raise the temperature to 180°C at a uniform speed (1°C / min), keep it warm for 10 minutes, and then rapidly raise the temperature (5°C / min) to Boil, keep boiling for 30 minutes to stop the reaction, cool to room temperature, add 10ml of absolute ethanol to dilute, then add 30ml of ethyl acetate for flocculation, separate with a magnet, wash with ethyl acetate for 3 times, and then ultrasonically disperse into deionized water to obtain Fe 3 o 4 Nanoparticle sol.

[0025] figure 1 Shown is the Fe obtained in this example 3 o 4 Transmission electron microscope (TEM) image of nanoparticles.

Embodiment 2

[0026] Embodiment 2 coprecipitation method prepares Fe 3 o 4 Nanoparticle sol

[0027] Weigh 7.8176g FeCl 6H 2 O and 3.7644g FeSO 4 ·7H 2 O, put it into a four-necked flask, and add 80ml deionized water, pass N 2 Protect. Stir, heat to constant temperature to 80°C, add 10ml NH 3 ·H 2 O, heat preservation reaction 60min. After the reaction is completed, the black solid is separated from the reaction solution with a magnet, washed 3 times with deionized water, and then ultrasonically dispersed in deionized water to obtain Fe 3 o 4 Nanoparticle sol.

Embodiment 3

[0029] With the prepared Fe in embodiment 1 or embodiment 2 3 o 4 The nanoparticle sol was exposed to air for two months to obtain partial oxidation of Fe 3 o 4 Nanoparticle sol.

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Abstract

The invention relates to a magnetic iron-oxide nanoparticle covering method using silicon dioxide and belongs to the technical field of nano material preparation. The magnetic iron-oxide nanoparticle covering method using the silicon dioxide mainly comprises preparing water-soluble magnetic iron-oxide nanoparticles through a known method; adding appropriate surface modifier into water base dispersion liquid to form into stable water base dispersion liquid; adding simple substance metal silica powder into the water base dispersion liquid, heating and stirring, enabling the silica powder to hydrolyze under catalysis of alkaline substance to generate into silicon dioxide to be deposited on surfaces of the magnetic iron-oxide nanoparticles and obtaining the silicon dioxide covered magnetic iron-oxide nanoparticles. The magnetic iron-oxide nanoparticle covering method using the silicon dioxide has the advantages of being simple in preparation technology, green and environmental friendly, easily available in material and low win cost and achieving large-scale industrialized production due to the fact that organic solvent and surface active agent are not required in the preparation process and the covering reaction is performed in water solution; enabling obtained products to be strong in morphology controllability, high in purity degree and particularly suitable for biomedical application; being widely applied to silicon dioxide covering of other nanocrystallines such as quantum dots and precious metal nano particles.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and relates to a method for coating the surface of magnetic iron oxide nanoparticles, in particular to a method for coating magnetic iron oxide nanoparticles with silicon dioxide. Background technique [0002] Magnetic iron oxide refers to Fe with ferrimagnetism 3 o 4 , Partially oxidized Fe 3 o 4 or γ-Fe 2 o 3 , its nanoparticles have unique magnetic properties and good biological safety, and have a wide range of uses in biomedical fields such as cell separation, targeted drug delivery, magnetic resonance imaging (MRI), gene delivery, and tumor hyperthermia. Research hotspots in the field of biomaterials. Non-surface-modified magnetic iron oxide nanoparticles have high surface energy, large specific surface area, and strong magnetic dipole interaction. They are prone to chemical reactions such as agglomeration, corrosion, and degradation in aqueous solution. At the same ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F41/02H01F1/01
Inventor 万家齐陈克正骆华锋王书宪唐婧张冲宇
Owner QINGDAO UNIV OF SCI & TECH
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