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Magnetism polymer nanometer microsphere material capable of degrading ring structure, as well as preparation method and application of magnetism polymer nanometer microsphere material

A technology of nano-microspheres and polymers, applied in the field of biomedicine, can solve the problems of unfavorable therapeutic effect and low drug loading, and achieve the effects of high drug loading rate, high drug loading, and good biodegradability

Inactive Publication Date: 2014-10-01
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reported contrast agents are usually too low in drug loading, which is not conducive to their therapeutic effect, so the preparation of dual-mode contrast agents with high drug loading is also a critical issue

Method used

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  • Magnetism polymer nanometer microsphere material capable of degrading ring structure, as well as preparation method and application of magnetism polymer nanometer microsphere material
  • Magnetism polymer nanometer microsphere material capable of degrading ring structure, as well as preparation method and application of magnetism polymer nanometer microsphere material
  • Magnetism polymer nanometer microsphere material capable of degrading ring structure, as well as preparation method and application of magnetism polymer nanometer microsphere material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of magnetic polymethacrylic acid (PMAA) nanospheres with degradable bell structure

[0033] (1) Polyglutamic acid (PGA) stabilized Fe 3 o 4 Synthesis of Magnetic Clusters: FeCl 3 ·6H 2 O (1.35 g), NH 4 Ac (3.85 g) and PGA (0.50 g) were added to ethylene glycol (70 mL), heated to 160 o C, after reacting for 1 h, the mixed solution was transferred to an autoclave (100 mL) and placed in a 200 o C in an oven for 16 h. After cooling to room temperature, centrifuge to remove solvent and unreacted monomer, wash with ethanol and water repeatedly for 3-5 times, and place in a vacuum oven for 45 o C dried for 24 h to obtain polyglutamic acid-stabilized Fe 3 o 4 magnetic cluster.

[0034] (2) Synthesis of magnetic nanospheres coated with a monolayer of uncrosslinked PMAA: polyglutamic acid (PGA) stabilized Fe 3 o 4 Magnetic clusters (100 mg), MAA (500 mg), AIBN (16mg) and acetonitrile (40 mL), added to a 100 mL one-necked bottle, heated to 100 ...

Embodiment 2

[0037] Example 2: Preparation of magnetic polyacrylic acid (PAA) nanospheres with degradable bell structure

[0038] (1) Polyglutamic acid (PGA) stabilized Fe 3 o 4 Synthesis of Magnetic Clusters: FeCl 3 ·6H 2 O (1.35 g), NH 4 Ac (4.15 g) and PGA (0.50 g) were added to ethylene glycol (70 mL), heated to 160 o C, after reacting for 1 h, the mixed solution was transferred to an autoclave (100 mL) and placed in a 200 o C in an oven for 16 h. After cooling to room temperature, centrifuge to remove solvent and unreacted monomer, wash with ethanol and water repeatedly for 3-5 times, and place in a vacuum oven for 45 o C dried for 24 h to obtain polyglutamic acid-stabilized Fe 3 o 4 magnetic cluster.

[0039] (2) Synthesis of magnetic nanospheres coated with monolayer uncrosslinked PAA: polyglutamic acid (PGA) stabilized Fe 3 o 4 Magnetic clusters (100 mg), AA (400 mg), AIBN (12mg) and acetonitrile (40 mL), added to a 100 mL single-necked bottle, heated to 100 o C, refl...

Embodiment 3

[0042] Example 3: Preparation of magnetic hydroxypolyethyl methacrylate (PHEMA) nanospheres with degradable bell structure

[0043] (1) Fe stabilized by chitosan 3 o 4 Synthesis of Magnetic Clusters: FeCl 3 ·6H 2 O (1.35 g), NH 4 Ac (3.85 g) and chitosan (0.60 g) were added to ethylene glycol (70 mL), heated to 160 o C, after reacting for 1 h, the mixed solution was transferred to an autoclave (100 mL) and placed in a 200 o C in an oven for 16 h. After cooling to room temperature, centrifuge to remove solvent and unreacted monomer, wash with ethanol and water repeatedly for 3-5 times, and place in a vacuum oven for 45 o C dried for 24 h to obtain chitosan-stabilized Fe 3 o 4 magnetic cluster.

[0044] (2) Synthesis of magnetic nanospheres coated with a monolayer of uncrosslinked PHEMA: Chitosan-stabilized Fe 3 o 4 Magnetic clusters (100 mg), HEMA (500 mg), AIBN (16mg) and acetonitrile (40 mL), added to a 100 mL single-necked bottle, heated to 100 o C, reflux reac...

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Abstract

The invention belongs to the technical field of biological medicine, and particular relates to a magnetism polymer nanometer microsphere material capable of degrading ring structure , as well as a preparation method and application of the magnetism polymer nanometer microsphere material. The backflow precipitation polymerization technology is adopted in the invention, Fe3O4 magnetic clusters stabilized by polyglutamate or agarose are used as cores; a polymer shell which is not crosslinked is firstly wrapped on the exterior, a new polymer shell with crosslinked disulfide bond is secondly wrapped, alcohol or water is used for etching the polymer not crosslinked, and the degradable magnetism polymer microcapsules with crosslinked disulfide bond are obtained. The method provided by the invention is quick and simple in post-treatment, requires no etching using a strong acid or a strong alkali, and is safe and efficient; the prepared material can is very good monodispersity, and can be applied to the fields of ultrasound and magnetic resonance image formation contrast agent and medicine carrier.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a magnetic polymer nano-microsphere material with a biodegradable bell structure and a preparation method and application thereof. Background technique [0002] In the field of biomedical imaging, each imaging technology has its own unique advantages, but at the same time has some shortcomings that cannot be overcome by itself. Ultrasound imaging (US) technology uses the difference in the strength of reflection and scattering signals of ultrasound at the interface of human tissue to transmit biological internal information. Because low-intensity ultrasound causes little damage to human tissue, it is safe, widely applicable, real-time, and repeatable. , strong ability to identify soft tissue, high flexibility and low price, etc., the sensitivity and resolution of ultrasound imaging are very low, when two soft tissue interfaces have similar acoustic impedance, the r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/12A61K47/36A61K47/34A61K47/04A61K31/704A61P35/00
Inventor 杨朋汪长春
Owner FUDAN UNIV
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