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A kind of Sanhuang Xiexin Tang formula granule and its preparation method and detection method

A technology of Sanhuang Xiexin decoction and formula granules, which can be used in the preparation of pharmaceutical formulas, test samples, and medical preparations containing active ingredients, etc., and can solve problems such as drug effect and the like

Active Publication Date: 2016-11-16
KANGMEI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, single-flavored traditional Chinese medicine formula granules, directly ingested, have a certain impact on its efficacy.

Method used

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  • A kind of Sanhuang Xiexin Tang formula granule and its preparation method and detection method
  • A kind of Sanhuang Xiexin Tang formula granule and its preparation method and detection method
  • A kind of Sanhuang Xiexin Tang formula granule and its preparation method and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Preparation of Example 1 Sanhuang Xiexin Decoction Formula Granules

[0093] 1. Source of medicinal materials, as shown in Table 1 below.

[0094] Table 1

[0095]

[0096] 2. Instruments and equipment

[0097] B-290 Spray Dryer, Swiss Buqi Company; RE-5205 Rotary Evaporator, Shanghai Yarong Biochemical Instrument Factory.

[0098] 3. Preparation method

[0099] Get 10g of rhubarb, 5g of rhubarb rhizome, 5g of scutellaria baicalensis, soak in water, then decoct, filter, combine the filtrate, concentrate under reduced pressure at 70°C, and concentrate the filtrate to a clear paste with a relative density of 1.15 (60°C), spray dry, and the air inlet temperature is 160°C, air outlet temperature 80°C, pump speed 2%, dry to obtain dry extract powder; then put the dry extract powder into a dry granulator, granulate, and pack the granules separately, 3g per bag.

[0100] The specific conditions are shown in Table 2 below:

[0101] Table 2 Selection of decoction times...

Embodiment 2

[0124] Embodiment 2 Thin-layer chromatography identification embodiment 1 is A in process condition 2 B 3 C 2 made in three Huangxiexin Decoction Granules

[0125] 1. Identification of rhubarb in Sanhuang Xiexin Decoction Granules

[0126] 1.1 Medicinal materials and reagents

[0127] Rhubarb control medicinal material: batch number 110715-200212, purchased from China Institute for the Control of Pharmaceutical and Biological Products;

[0128] Test product: Sanhuang Xiexin Tang formula granules prepared according to the method described in Example 1, with batch numbers of 2011122601 and 2011122602, manufactured by Kangmei Pharmaceutical Co., Ltd.

[0129] Thin layer plate: silica gel G plate, purchased from Kangmei Pharmaceutical Co., Ltd.

[0130] 1.2 Test steps

[0131] The preparation of the first rhubarb test sample: Take 0.25g of this product, add methanol 5ml, ultrasonic treatment for 5 minutes, take the supernatant as the test solution.

[0132] Pr...

Embodiment 3

[0144] Embodiment 3 measures that embodiment 1 is A at process condition 2 B 3 C 2 Sanhuang Xiexin Decoction prepared at that time Fingerprints of square particles

[0145] 1. Instruments and reagents

[0146] 1.1 Instrument: High performance liquid chromatography: Agilent 1100 series; Chromatographic column: Ecosil HPLCCOLUM C18 (4.6×250mm, 5μm); Electronic analytical balance: XP-6; FA2104; Ultrasonic extractor: KQ-300VDB dual-frequency digital control ultrasonic cleaning instrument.

[0147] 1.2 Reagents: Methanol is chromatographically pure, water is ultrapure water; other reagents are analytically pure.

[0148]1.3 Reagent: Sanhuang Xiexin Decoction Formula Granules prepared according to the method described in Example 1, batch number 2011122602, and baicalin reference substance (National Institute for the Control of Pharmaceutical and Biological Products, batch number: 110715-200212).

[0149] 2. Chromatographic conditions and system adaptability The ch...

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Abstract

The invention provides a formula granule of Sanhuang Xiexin Decoction and its preparation method and detection method. The formula granule of Sanhuang Xiexin Decoction is decocted with rhubarb, scutellaria baicalensis and Coptis chinensis in a mass ratio of 2:1:1, and filtered. , and then concentrated and dried the filtrate; the detection method includes identifying the Sanhuang Xiexin Decoction formula granules by thin-layer chromatography; determining the fingerprint of the Sanhuang Xiexin Decoction formula granules by high performance liquid chromatography; Determination of the extract content of the Sanhuang Xiexin Decoction granules by hot soaking method; determination of the substance content in the Sanhuang Xiexin Decoction formula granules by high performance liquid chromatography. The Sanhuang Xiexin Decoction of the present invention is decocted according to the traditional method, which gives full play to the advantages of Chinese medicine compatibility, embodies the overall concept of Chinese medicine, ensures that it achieves the purpose of reducing toxicity and increasing efficiency, and overcomes the simple taste of each medicine when taking the current single-flavor formula granules. The shortcomings brought about by the addition established the technological conditions and perfect quality standards of Sanhuang Xiexin Tang formula granules.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. It specifically relates to a traditional Chinese medicine and its preparation method and detection method, in particular to a Sanhuang Xiexin Tang formula granule and its preparation method and detection method. Background technique [0002] Sanhuang Xiexin Decoction, also known as Dahuanghuanglian Xiexin Decoction, comes from the volume of Zhang Zhongjing's "Synopsis of the Golden Chamber". It is mainly used to treat internal blaze of evil fire, forcing blood to flow indiscriminately, vomiting blood, epistaxis, constipation and redness; or jaundice caused by internal dampness and heat. Accumulated heat in the three energizers, red and swollen eyes, sores on the mouth and tongue, external syndrome sores, dysphoria in the heart and chest, constipation; damp-heat jaundice, dysphoria and distension in the chest, yellow and greasy tongue coating, rapid and rapid pulse. Commonly used prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/02G01N30/36G01N30/06G01N1/28A61K36/718A61K9/16A61P31/00
Inventor 金维维许冬瑾马兴田向飞军吴小明陈有军
Owner KANGMEI PHARMA
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