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A kind of preparation method of Xiangfu Siwu granules and its quality detection method

A quality inspection method and the technology of Cyperus folium, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as differences, bitter taste of soup, mildew and deterioration

Active Publication Date: 2020-10-30
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the disadvantages of deployment, carrying, temporary decoction, and long-term storage, it is prone to mildew and deterioration, the soup tastes bitter, and the quantity is large. It cannot meet the living requirements of modern people.
Traditional Chinese medicine formula granules maintain the multiple effects of single medicines, and retain the active ingredients of medicines to the greatest extent. However, at present, traditional Chinese medicine formula granules are all single Chinese medicine extracts. The difference between "co-frying" and "separate frying"

Method used

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  • A kind of preparation method of Xiangfu Siwu granules and its quality detection method
  • A kind of preparation method of Xiangfu Siwu granules and its quality detection method
  • A kind of preparation method of Xiangfu Siwu granules and its quality detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] A preparation method of Cyperus siwu granules, comprising the steps of:

[0103] a. Take Cyperus cyperi 300g, Muxiang 200g, Angelica 600g, Ligusticum chuanxiong 300g, add 14kg of water, soak for 12 hours, steam distillation for 10 hours to extract volatile oil.

[0104] b. Add β-cyclodextrin (the amount added is 10 times the volume of the volatile oil) and water (the amount added is 30 times the volume of the volatile oil) to the volatile oil and grind for 2 hours, freeze-dry to obtain the inclusion compound of the volatile oil.

[0105] c. Add 800g of Rehmannia glutinosa, 300g of Radix Paeoniae Alba and 300g of Corydalis Corydalis in corresponding proportions to the residue obtained after extraction of volatile oil, add water and decoct twice, add 30kg of water each time, decoct for 2 hours, extract the medicinal liquid, combine the medicinal liquid, filter, Dry under reduced pressure to a concentrated solution with a relative density of 1.05, add 95% ethanol until the...

Embodiment 2

[0128] A preparation method of Cyperus siwu granules, comprising the steps of:

[0129] a. Take Cyperus cyperi 300g, Muxiang 200g, Angelica sinensis 600g, Ligusticum chuanxiong 300g, add 16.8kg of water, soak for 15 hours, steam distill and extract for 8 hours to extract volatile oil.

[0130] b. Add β-cyclodextrin (the amount added is 8 times the volume of the volatile oil) and water (the amount added is 20 times the volume of the volatile oil) to the volatile oil and grind for 2 hours, then freeze-dry to obtain the inclusion compound of the volatile oil.

[0131] c. Add 800g of Rehmannia glutinosa, 300g of Radix Paeoniae Alba and 300g of Corydalis Corydalis in corresponding proportions to the residue obtained after extraction of volatile oil, add water to decoct twice, add 28kg of water each time, decoct for 2 hours, extract the medicinal liquid, combine the medicinal liquid, filter, Dry under reduced pressure to a concentrated solution with a relative density of 1.13, add 9...

Embodiment 3

[0153] A preparation method of Cyperus siwu granules, comprising the steps of:

[0154] a. Take Cyperus cyperi 300g, Muxiang 200g, Angelica sinensis 600g, Ligusticum chuanxiong 300g, add 16.8kg of water, soak for 15 hours, steam distill and extract for 8 hours to extract volatile oil.

[0155] b. Add β-cyclodextrin (the amount added is 8 times the volume of the volatile oil) and water (the amount added is 20 times the volume of the volatile oil) to the volatile oil and grind for 2 hours, then freeze-dry to obtain the inclusion compound of the volatile oil.

[0156] c. Add 800g of Rehmannia glutinosa, 300g of Radix Paeoniae Alba and 300g of Corydalis Corydalis in corresponding proportions to the residue obtained after extraction of volatile oil, add water to decoct twice, add 28kg of water each time, decoct for 2 hours, extract the medicinal liquid, combine the medicinal liquid, filter, Dry under reduced pressure to a concentrated solution with a relative density of 1.13, add 9...

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Abstract

The invention discloses a preparation method and a quality control method of rhizoma cyperi four-material granules. The preparation method comprises the steps of extracting volatile oil from four medicinal materials including angelica, Szechuan lovage rhizome, rhizoma cyperi and costus root by adopting a steam distillation method, performing grinding inclusion on the volatile oil by adopting beta-cyclodextrin, adding prepared rehmannia root, white peony root and rhizoma corydalis into the residue obtained after the volatile oil is extracted, adding water for decocting and extracting, precipitating the extract by using 95% ethanol, standing, filtering, concentrating the supernate under reduced pressure, drying to obtain a dry extract, adding powdered sugar and dextrin, mixing uniformly, granulating, drying, shaping, adding an inclusion compound, and mixing uniformly, thus obtaining the four-material granules. The quality control method comprises thin-layer qualitative identification and HPLC (High Performance Liquid Chromatography) content measurement. The volatile oil is separately extracted and included, so that double effects of reducing the consumption of accessories and exerting the treatment effect are achieved; compared with the conventional single-formula granules, the four-material granules having various medicinal flavors can sufficiently exert the advantage of compatibility of Chinese medicaments; and a perfect quality standard is established, so that the quality of the compound granules can be effectively controlled.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Xiangfu Siwu granules and a quality control method thereof. Background technique [0002] Xiangfu Siwu Decoction is composed of seven herbs such as Cyperi cyperi, Muxiang, Corydalis Corydalis, Angelica, Chuanxiong, Rehmannia glutinosa, and Paeoniae Alba. It is one of the representative prescriptions for promoting qi and removing blood stasis. It has the effects of nourishing blood and regulating blood, promoting qi and relieving pain, and mainly treating dysmenorrhea and irregular menstruation caused by qi stagnation and blood stasis. [0003] The occurrence of dysmenorrhea is mainly related to the increase in the synthesis and release of prostaglandins in the endometrium during menstruation, the hyperreactivity of the uterine muscle, and the secondary ischemia of the myometrium leads to pain. Traditional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61K9/16A61K47/69A61P15/00A61P29/00G01N30/02G01N30/90
CPCA61K9/1652A61K36/232A61K36/236A61K36/285A61K36/65A61K36/66A61K36/71A61K36/804A61K36/8905A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55G01N30/02G01N30/90A61K2300/00
Inventor 段金廒钱大玮刘培宿树兰
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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