Method for rapid determination of soluble solids in compound ass-hide glue pulp by near infrared spectroscopy

Abstract

The invention discloses a method for rapid determination of the content of soluble solids in a compound ass-hide glue pulp by near infrared spectroscopy, and belongs to the traditional Chinese medicine research technical field. The method comprises the steps: preparing different concentrations of compound ass-hide glue pulp samples by concentration dilution, and jointly forming a sample set with a finished product sample; acquiring near infrared spectrograms of the samples in the sample set, eliminating abnormal samples, and dividing the sample set; then selecting an appropriate spectral wave band and an appropriate pretreatment method to obtain compound ass-hide glue pulp characteristic spectral information; taking the soluble solid content tested by a moisture test apparatus as a reference value, and building a quantitative calibration model of the relationship between the ass-hide glue pulp near infrared spectrum and the soluble solid content by applying a stechiometry technology; and acquiring a near infrared spectrum of a compound ass-hide glue pulp sample with unknown content, and rapidly calculating the soluble solid content by utilizing the built quantitative calibration model. The method is beneficial for improving the level of quality control of the compound ass-hide glue pulp, and ensures stability and reliability of the product quality.

Description

technical field [0001] The invention relates to a method for measuring soluble solids in compound donkey-hide gelatin, and more particularly to a method for rapidly determining the content of soluble solids in compound donkey-hide gelatin by near-infrared spectroscopy. The invention belongs to the technical field of traditional Chinese medicine research. Background technique [0002] The inspection of finished drug products is the last quality control procedure that a drug must go through before entering the market, which is directly related to the drug safety of consumers. At present, the detection methods of traditional Chinese medicines are mostly chromatographic methods. Such methods require complex sample pretreatment before analysis, and the analysis time is also long. Moreover, traditional measurement methods can only measure one index at a time, which prolongs the total consumption of the batch production process. Time. [0003] Compound Ejiao paste is a Chinese med...

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Problems solved by technology

[0004] In the 2010 edition of "Chinese Pharmacopoeia", the determination of the content of compound donkey-hide gelatin pulp is only one item of total nitrogen, which is not enough to reflect the overall status of the active ingredients in the finished product of compound donkey-hide gelatin pulp, and it is difficult to meet the requirements for content analysis and monitoring of the finished product of compound donkey-hide gelatin pulp

[0006] However, due to the complex composition of Chinese patent medicines, the low content of active ingredients and the serious absorption overlap in their near-infrared spectra, there are still few reports on the near-infrared spectroscopy of traditional Chinese medicine preparations.

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