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Compound anesthetic for rat and preparation method thereof

An anesthetic and compound technology, applied in the field of compound anesthetics, can solve problems such as high blood pressure, fast heart rate during anesthesia maintenance time, etc., and achieve the effect of accelerating anesthesia, reducing dosage, and reducing stress response

Inactive Publication Date: 2014-09-24
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing rat anesthesia and Baoding still stay at the use of above-mentioned single drug, the discussion of dose and the mutual comparison stage of several medicines, need a kind of new compound anesthetic preparation badly, solve existing rat anesthetic in sedation, analgesia. , induction time, anesthesia maintenance time, etc., as well as prominent problems such as rapid heart rate and high blood pressure caused by excessive stress in rats

Method used

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  • Compound anesthetic for rat and preparation method thereof
  • Compound anesthetic for rat and preparation method thereof
  • Compound anesthetic for rat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 compound anesthetic

[0038] Each component and its content in the compound anesthetic are: the content of each component in each 100mL compound anesthetic is 15 mg of dexmedetomidine, 135 mg of midazolam, 7 mg of oxycodone, 680 mg of potassium dihydrogen phosphate, and 116.4 mg of sodium hydroxide mg, the balance is water for injection.

[0039] The preparation method of the compound anesthetic comprises the following steps: dissolving dexmedetomidine, midazolam, oxycodone, potassium dihydrogen phosphate, and sodium hydroxide in water for injection successively, adding water for injection to dilute, filtering, Fill and seal in ampoules, and sterilize under high pressure to obtain the product.

Embodiment 2

[0040] The preparation of embodiment 2 compound anesthetic

[0041] Each component and its content in the compound anesthetic are: the content of each component in each 100mL compound anesthetic is 15 mg of dexmedetomidine, 135 mg of midazolam, 7 mg of oxycodone, 14 mg of atropine, 680 mg of potassium dihydrogen phosphate, hydrogen Sodium oxide 116.4mg, the balance is water for injection.

[0042] The preparation method of compound anesthetic comprises the following steps: dissolving dexmedetomidine, midazolam, oxycodone, atropine, potassium dihydrogen phosphate, and sodium hydroxide in water for injection in sequence, and then adding water for injection to dilute, Filter, seal in ampoules, and sterilize under high pressure.

Embodiment 3

[0043] The preparation of embodiment 3 compound anesthetic

[0044] Each component and its content in the compound anesthetic are as follows: the content of each component in each 100mL compound anesthetic is 15 mg of dexmedetomidine, 135 mg of midazolam, 6.5 mg of oxycodone, and the balance is water for injection.

[0045] The preparation method of the compound anesthetic comprises the following steps: dissolving dexmedetomidine, midazolam and oxycodone in water for injection successively, then adding water for injection to dilute, filtering, filling and sealing in an ampoule bottle, Sterilize, that is.

[0046] experimental animals

[0047] 180 SD rats, 2-2.5 months old, half male and half male, body weight 258±23g, provided by the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine, were fed under the same conditions for 4 weeks for the experiment, and the feeding and management conditions were maintained throughout the experiment. unanim...

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Abstract

The invention discloses a compound anesthetic for a rat and a preparation method thereof and belongs to the field of preparation and application of animal compound anesthetics. The invention discloses the compound anesthetic for the rat for the first time. The compound anesthetic comprises dexmedetomidine, midazolam, oxycodone, a buffer solution and water for injection. The invention further discloses the preparation method of the compound anesthetic for the rat. The preparation method comprises the following steps: dissolving the above components in the water for injection; diluting; filtering; pilling in an ampoule bottle; and sterilizing to obtain. The compound anesthetic for the rat disclosed by the invention is quick in anesthesia induction, long in anesthesia maintenance time, good in antalgic and sedative effects and stable in revival, and the main influence on physiological and biochemical indexes of the rat is within the physiological range tolerance. The compound anesthetic is simple to operate and can be used for complex or long-term operations of the rat.

Description

technical field [0001] The invention relates to a compound anesthetic, in particular to a compound anesthetic for rats and a preparation method thereof, belonging to the field of preparation and application of a compound anesthetic for rodents. Background technique [0002] In animal experiments, choosing an appropriate, safe, and effective anesthesia method is an important basis for experimental safety and data reliability. Rats are often used in the research of drug nutrition metabolism, endocrine, behavior, geriatrics, tumor, infectious disease, cardiovascular disease, etc. Pathophysiological changes, even death, affect the results of the entire experiment. [0003] At present, the commonly used rat anesthesia preparations in China include chloral hydrate, urethane, pentobarbital, ketamine, Sumianxin and so on. Chloral hydrate is a short-acting anesthetic. The relative safety range of 10% chloral hydrate is small, the depth of anesthesia is shallow, and the muscle relax...

Claims

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Application Information

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IPC IPC(8): A61K31/5517A61P23/00A61K31/4174A61K31/485A61K31/46
Inventor 范宏刚时静安海军姜胜唐琪超刘海玉刁红秀李妍李娜贾烁白鸽付礼胜边钰
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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