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Anticancer nano medicament loading arsenical and preparation method thereof

A nano-drug and nano-sphere technology, which is applied in the direction of anti-tumor drugs, drug combinations, and pharmaceutical formulations, can solve the problems of unfavorable drug efficacy and fast metabolism, and achieve the effects of easy scale-up preparation, simple process steps, and convenient operation

Active Publication Date: 2014-07-16
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because arsenate exists in an ion state in the living body, it is mainly distributed in the blood and metabolized too fast in the living body, which is not conducive to its medicinal effect on the cancerous solid lesion. Therefore, a new type of high-efficiency and controllable Arsenic-based cancer drug could shed new light on cancer treatment

Method used

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  • Anticancer nano medicament loading arsenical and preparation method thereof
  • Anticancer nano medicament loading arsenical and preparation method thereof
  • Anticancer nano medicament loading arsenical and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Example 1: Preparation of hollow silica nanomaterials with a radius of 30 nm

[0033]In a 50 mL round bottom flask, 60 mg of iron oxide nanoparticles with uniform particle size distribution were added and dissolved in 20 mL of cyclohexane, while 900 μL of Co-520, 200 μL of tetraethoxysilane and 400 μL of ammonia were added. The mixed solution was stirred (rotating speed: 800rpm), mixed evenly, and kept at the rotating speed for 16h. Then, 10 μL of 3-aminopropyltriethoxysilane was added to the reaction liquid and reacted for 2 h. After the reaction was completed, about 1 mL of absolute ethanol was added dropwise to the reaction liquid and centrifuged at 5000 rpm for 2 min. The resulting precipitate was redissolved in 10 mL of ultrapure aqueous solution to obtain hollow silica nanoparticles with a radius of 30 nm (see figure 2 ). figure 1 A schematic diagram of the anticancer nanomedicine loaded with arsenic agent according to the present invention is given.

Embodiment 2

[0034] Example 2: Ni,AsSiO 2 Preparation of anticancer nanomedicine

[0035] Add 2 mL of hollow silica nanoparticle solution with a concentration of 10 mg / mL and 3 mL of 600 mM nickel acetate solution in a 10 mL round bottom flask. The mixed solution was placed in a water bath at 50°C and an ice-water bath at 0°C in sequence, and circulated 10 times. After 10 rounds of cycles were completed, the excess nickel acetate solution was discarded by centrifugation (14000 rpm), and 3 mL of 150 mM ATO aqueous solution (pH 8) was added thereto. The mixture was placed in a 50°C water bath for 6h. After the reaction is complete, centrifuge at 14,000rpm for 30min, add 2mL of ultrapure water to dissolve the precipitate, and obtain Ni, AsSiO 2 Anticancer nanomedicines (see image 3 and 4 ).

Embodiment 3

[0036] Example 3: Mn, AsSiO 2 Preparation of anticancer nanomedicine

[0037] Add 2 mL of hollow silica nanoparticle solution with a concentration of 10 mg / mL and 3 mL of 600 mM manganese chloride solution in a 10 mL round bottom flask. The mixed solution was placed in a water bath at 50°C and an ice-water bath at 0°C in sequence, and circulated 10 times. After 10 rounds of cycles were completed, the excess manganese chloride solution was discarded by centrifugation (14000 rpm), and 3 mL of 150 mM ATO aqueous solution (pH 8) was added thereto. The mixture was placed in a 50°C water bath for 6h. After the reaction is complete, centrifuge at 14,000rpm for 30min, add 2mL of ultrapure water to dissolve the precipitate, and obtain Mn, AsSiO 2 Anticancer nanomedicines (see Figure 5 ).

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Abstract

The invention discloses an anticancer nano medicament loading an arsenical and a preparation method thereof, and relates to a nano medicament. The anticancer nano medicament loading the arsenical comprises an arsenite complex and a carrier, wherein the arsenite complex is loaded on the carrier and formed by As ions and most transition metal ions; the most transition metal ions comprise one of Mn, Fe, Ni, Zn, Pt, Co, Pb and the like; and the carrier is a silicon dioxide nano material with a pore structure. Hollow silicon dioxide nano spheres are synthesized first, then mesoporous silicon dioxide nano spheres are synthesized, and finally, the anticancer nano medicament loading the arsenical is prepared. The process steps are simple, the operation is convenient, the yield is relatively high, and amplified preparation is facilitated; and the anticancer nano medicament loading the arsenical has a strong anticancer effect, and can effectively control the growth and migration of tumors on the premise that cancer cells are effectively killed so as to effectively treat the cancer.

Description

technical field [0001] The invention relates to a nano-medicine, in particular to an anti-cancer nano-medicine loaded with arsenic agent and a preparation method thereof with high-efficiency anti-cancer effect. Background technique [0002] Chemotherapy as a method of treating cancer has been widely used in the clinical treatment of cancer today. Traditional anticancer drugs (such as doxorubicin, paclitaxel, etc.) can only kill cancer cells, but cannot inhibit the migration of cancer cells. As a result, cancer patients often relapse due to cancer migration and are difficult to recover. As 2 o 3 (ATO), as an inorganic drug against blood cancer, has been approved by the US Food and Drug Administration and has entered clinical treatment (Wang, Z.-Y. & Chen, Z., Blood2008, 111, 2505). Studies have shown that ATO can not only effectively kill cancer cells, but also promote the differentiation of cancer cells to normal cells and effectively suppress the migration of cancer cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/36A61K47/04A61P35/00A61K33/24A61K33/26A61K33/30A61K33/32
Inventor 高锦豪赵征寰王效民尹震宇池小琴李辉
Owner XIAMEN UNIV
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