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Sulforaphane and platinum medicine anti-cancer combination preparation

A technology of sulforaphane and platinum, applied in the field of pharmaceutical preparations used in tumor treatment, to achieve the effect of enhancing the curative effect

Inactive Publication Date: 2008-04-30
BEIJING TUBERCULOSIS & THORACIC TUMOR RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although there are many studies on the combined drug or combined preparation with cisplatin, it is still necessary to find a combined drug and combined preparation with stronger synergistic effect and reduced side effects.

Method used

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  • Sulforaphane and platinum medicine anti-cancer combination preparation

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Embodiment Construction

[0018] The present invention will be further clarified through the detailed description of specific embodiments below in conjunction with the accompanying drawings, but it is not intended to limit the present invention, but only for illustration.

[0019] 1. Materials and methods

[0020] 1. Experimental cell line: Human lung adenocarcinoma cell line LTEP-A2 was established by our laboratory (Wang Hui, Lai Baitang, Zhan Xiuping et al., Establishment of two human lung adenocarcinoma cell lines and observation of their biological characteristics Chinese Journal of Oncology 1983, 5(2):85-88). The cells were maintained in RPMI-1640 (GIBCO) culture medium containing 20% ​​fetal bovine serum, digested with 0.25% trypsin and 0.02% EDTA and then subcultured.

[0021] 2. In vitro inhibition test of DDP and SFN on A2 cells: A2 cells in the logarithmic growth phase were digested into single cells, and seeded in 35mm-diameter dishes, with 500 cells per dish. After dissolving DDP and SFN...

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Abstract

The anti-cancer combined preparation containing sulforaphane and platinum drugs is used for the treatment of cancer, especially lung cancer, and the components can be administered simultaneously, separately or sequentially. Among them, sulforaphane increases the anticancer effect of platinum anticancer drugs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to pharmaceutical preparations used in tumor treatment. Background technique [0002] In the past 30 years, the incidence and mortality of lung cancer in my country have shown a continuous upward trend, and the high-incidence cancer spectrum in my country has also shown an obvious trend of change. In the 1970s, the main tumors were gastric cancer, esophageal cancer, liver cancer, lung cancer, and cervical cancer. In 2000, they evolved into lung cancer, liver cancer, gastric cancer, esophageal cancer, and colorectal cancer. The mortality rate decreased most obviously for cervical cancer, and the most obvious increase was for lung cancer. In many areas, especially in cities, lung cancer has become the No. 1 cause of death. In the next 20 to 30 years, my country's cancer mortality rate will continue to rise, and will become a major problem in disease prevention and control. [0003] Cisplati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/282A61P35/00A61K31/26
Inventor 赖百塘汪惠
Owner BEIJING TUBERCULOSIS & THORACIC TUMOR RES INST
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