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Glutamic acid chelated calcium prepared by using eggshells as calcium source and preparation method of glutamic acid chelated calcium

A technology for chelating calcium glutamate and poultry egg shells, which is applied in chemical instruments and methods, cyanide reaction preparation, organic compound preparation and other directions, can solve problems such as affecting the health of users, poor solubility, acid pollution, etc. The effect of highlighting the calcium absorption effect

Inactive Publication Date: 2014-06-11
王子荣 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the utilization of eggshell calcium sources mainly uses acid hydrolysis to extract soluble calcium and high-temperature calcination. The method generally has defects such as acid pollution, environmental pollution, and organic solvent residues [5,6]. Directly using poultry eggshells as calcium There is no report on the preparation of amino acid chelated calcium by the direct reaction between the source and amino acid, and there is no report on the technical scheme of amino acid chelated calcium with high absorption rate that is simply prepared by using an environmentally friendly process using shell calcium sources.
Currently reported amino acid chelated calcium prepared from shellfish and other raw materials is widespread: first, the solubility is poor, only 0.02g of calcium carbonate can be dissolved in 100mL of water, and calcium ions can only be absorbed after neutralization and decomposition by gastric acid; Oysters and shellfish in the offshore, these marine organisms have a strong adsorption effect, not only can absorb a lot of plankton as food, but also can absorb heavy metals polluted in the ocean into shells
Therefore, this shell biological calcium carbonate contains heavy metals, which affects the health of users

Method used

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  • Glutamic acid chelated calcium prepared by using eggshells as calcium source and preparation method of glutamic acid chelated calcium
  • Glutamic acid chelated calcium prepared by using eggshells as calcium source and preparation method of glutamic acid chelated calcium
  • Glutamic acid chelated calcium prepared by using eggshells as calcium source and preparation method of glutamic acid chelated calcium

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The specific steps of the method for directly preparing glutamic acid chelated calcium by using poultry eggshells as a calcium source are as follows.

[0031] (1) Raw material pretreatment: After collecting poultry eggshells, wash the surface debris with clean water, boil in boiling water for 5-10 minutes, 40-60kHz, ultrasonic 20-30min for the first shell membrane separation, put it in a tunnel type blast drying box and use wind force Separate the shell membrane again, crush it through a 100-mesh sieve to obtain eggshell powder with high purity, and store it at 4°C for later use.

[0032] (2) Mix eggshell calcium powder and glutamic acid at a molar ratio of 1:2 to 1:3, add distilled water at a solid-to-liquid mass ratio of 1:15 to 1:20, adjust the pH value to 6-8 with NaOH, and heat Stir at 60-80°C at a speed of 20-30r / min to keep warm and chelate for 50-70min.

[0033] (3) The crude product of the chelation reaction obtained in the above steps is suction-filtered for ...

Embodiment 2

[0037] The specific steps of the method for directly preparing glutamic acid chelated calcium by using poultry eggshells as a calcium source are as follows.

[0038] (1) Raw material pretreatment: After collecting poultry eggshells, wash the surface debris with clean water, boil in boiling water for 5 minutes, 40kHz, and ultrasonically separate the shell and membrane for 20 minutes. 100-mesh sieve to obtain eggshell powder with relatively high purity, and store it at 4°C for later use.

[0039] (2) Mix eggshell calcium powder and glutamic acid in a molar ratio of 1:2, add distilled water at a solid-to-liquid mass ratio of 1:15, adjust the pH value to 6 with NaOH, heat to 60°C and keep stirring at a speed of 20r / min Chelation 50min.

[0040] (3) The crude product of the chelation reaction obtained in the above steps is suction-filtered for 5 minutes, and the filter residue is recovered and re-feeded for use; the filtrate is concentrated under reduced pressure and placed in a p...

Embodiment 3

[0044] The specific steps of the method for directly preparing glutamic acid chelated calcium by using poultry eggshells as a calcium source are as follows.

[0045] (1) Raw material pretreatment: After collecting poultry eggshells, wash the surface debris with clean water, boil in boiling water for 10 minutes, 60kHz, and ultrasonic for 30 minutes to separate the shell and membrane for the first time. 100-mesh sieve to obtain eggshell powder with relatively high purity, and store it at 4°C for later use.

[0046] (2) Mix eggshell calcium powder and glutamic acid at a molar ratio of 1:3, add distilled water at a solid-to-liquid mass ratio of 1:20, adjust the pH value to 8 with NaOH, heat to 80°C and keep stirring at a speed of 30r / min Chelation 70min.

[0047] (3) The crude product of the chelation reaction obtained in the above steps is suction-filtered for 10 minutes, and the filter residue is recovered and re-fed for use; the filtrate is concentrated under reduced pressure ...

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Abstract

The invention discloses glutamic acid chelated calcium prepared by using eggshells as a calcium source and a preparation method of glutamic acid chelated calcium. The glutamic acid chelated calcium is prepared by using the eggshells as a calcium source raw material and adopting direct reaction. Key technical parameters, namely the molar ratio, pH value, chelating temperature and chelating time, are subjected to response surface optimization design on the basis of a single factor test; the determined optimal preparation process conditions are as follows: the pH value of a solution is 6-8, the molar ratio of eggshell meal to glutamic acid is 1:2 to 1:3, the chelating temperature is 60-80 DEG C, and the chelating time is 50-70min. The prepared glutamic acid chelated calcium has a predominant calcium absorption effect through verification, the chelating rate of the glutamic acid is up to 63.88%, a high absorption type active calcium supplement preparation is obtained, the solubility of the preparation is 33-33.4%, the preparation is neutral in a 10% aqueous solution, the pH value of the preparation is 6.0-7.5, the preparation is good in stability, and the calcium content of the preparation is 10.9-13.5%, so that the preparation has a wide application value.

Description

technical field [0001] The invention relates to the technical field of preparation of glutamic acid chelated calcium, in particular, the invention relates to the technical field of glutamic acid chelated calcium directly prepared by using poultry eggshell as a calcium source. Background technique [0002] Calcium is one of the essential elements in the human body. It is an important component of human bones, teeth, organs, blood, and muscle tissue. When calcium is lacking in the human body, physiological dysfunction may occur. Amino acid chelated calcium is a compound with a ring structure formed by the coordination reaction of one or more amino acid groups with metallic calcium. It has good chemical and biochemical stability, is easy to be absorbed by the human body, has few side effects, and has high bioavailability. It can achieve the dual effects of supplementing both amino acids and calcium. It is an ideal calcium nutrition enhancer. [0003] Poultry eggshells are rich...

Claims

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Application Information

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IPC IPC(8): C07C227/18C07C229/76A61P3/02A61P19/10
Inventor 王子荣彭亦谷逄焕明
Owner 王子荣
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