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A kind of soft capsule containing milk thistle extract and preparation method thereof

A technology of soft capsules and extracts, which is applied in the directions of capsule delivery, medical preparations of inactive ingredients, and drug combinations, etc., can solve the problems of accumulation of polymer compounds and organic solutions, reduce alcohol-induced liver damage, and improve chemical properties. Effects of liver damage

Active Publication Date: 2016-03-09
侯文阁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The silymarin drugs and products currently on the market have the risk of polymer compounds and residual solvents from organic solutions accumulating in the body

Method used

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  • A kind of soft capsule containing milk thistle extract and preparation method thereof
  • A kind of soft capsule containing milk thistle extract and preparation method thereof
  • A kind of soft capsule containing milk thistle extract and preparation method thereof

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preparation example Construction

[0025] The method for preparing the soft capsules provided by the present invention comprises mixing milk thistle extract, medium-chain triglycerides, edible oil and phospholipids to obtain the contents of the soft capsules, and encapsulating the contents in the soft capsule shell .

[0026] Among them, the soft capsule shell can be prepared in a conventional way, for example, gelatin, purified water, glycerin, sorbitol, glycine and titanium dioxide are added with an appropriate amount of pigment (tartrazine or brilliant blue) to obtain gelatinization. Then, conventional scale preparation methods can be used to make pills, shape and dry, wash pills, dry pills, pick pills, make semi-finished products, and pack.

[0027]According to the present invention, the specific mixing method is not particularly limited, for example, the mixing method may be: dissolving milk thistle extract, edible oil and phospholipids in medium-chain triglycerides at 55-60°C Then cool down to 35-40°C fo...

Embodiment 1

[0031] Based on 1000 grains, under nitrogen protection, mix 80g of medium-chain triglycerides and 60g of poppy seed oil (unsaturated fatty acid content is 90% by weight), heat in a water bath to 55°C, and at this temperature, add 170g of soybean Phospholipids (batch number: 576500) and 0.06g vitamin E, stir until dissolved, then add 90g milk thistle extract, stir until dissolved, cool down to 35°C as the contents of the soft capsule for later use;

[0032] Prepare the soft capsule shell according to the following weight ratio: gelatin: purified water: glycerin: sorbitol: glycine: titanium dioxide=1:1:0.47:0.02:0.08:0.005 to carry out gelatinization, and the conventional manufacturing method is used to make pills, shape and dry, wash pills, dried pills, and picked pills to obtain soft capsule S-1.

Embodiment 2

[0040] Based on 1000 grains, under nitrogen protection, mix 50g of medium-chain triglycerides and 80g of poppy seed oil (unsaturated fatty acid content is 90% by weight), heat in a water bath to 55°C, and at this temperature, add 180g of soybean Phospholipids (batch number: 576500) and 0.06g vitamin E, stir until dissolved, then add 70g of milk thistle extract, stir until dissolved, cool down to 35°C as the contents of the soft capsule for later use;

[0041] Prepare the soft capsule shell according to the following weight ratio: gelatin: purified water: glycerin: sorbitol: glycine: titanium dioxide=1:1:0.47:0.02:0.08:0.005 to carry out gelatinization, and the conventional manufacturing method is used to make pills, shape and dry, wash pills, dried pills, and picked pills to obtain soft capsule S-2.

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Abstract

The invention discloses a soft capsule containing a silybum marianum extract and a preparation method of the soft capsule. The content of the soft capsule contains the following raw materials in parts by weight: 1 part of silybum marianum extract, 45-115 parts of medium chain triglycerides, 40-120 parts of edible oil and 140-300 parts of phospholipid relative to 1 part of silybum marianum extract; the unsaturated fatty acid content in the edible oil is not smaller than 70wt%; the content of phosphatidylcholine in the phospholipid is 20-80wt%; the content of the dilinoleoyl phosphatidylcholine is 20-80wt%. The preparation method of the soft capsule disclosed by the invention comprises the following steps: mixing the components to obtain the content of the soft capsule, and encapsulating the content into a soft capsule shell. By adopting the soft capsule disclosed by the invention, liver injury can be effectively improved, blood fat is reduced, and the active components such as the silybum marianum extract and the phospholipid in the soft capsule can stably exist for a long period of time.

Description

technical field [0001] The invention relates to a soft capsule containing milk thistle extract and a preparation method thereof. Background technique [0002] Milk thistle belongs to the Compositae herb and is a kind of herbal medicine in European folk for the treatment of liver and gallbladder diseases. In the late 1960s, German pharmacists extracted silymarin flavonoids from its seeds, and believed that the main active ingredient was silybin. Pharmacological studies in recent years have shown that silymarin has anti-free radical activity, anti-lipid peroxidation, anti-lipoxygenase, anti-tumor and hypolipidemic effects. It is the world-recognized liver injury repair drug with definite curative effect. Silibinin is poorly soluble in water, has poor oral absorption and low bioavailability. For this reason, new dosage forms have been actively developed at home and abroad to increase its dissolution rate or change its dissolution and absorption characteristics, thereby impro...

Claims

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Application Information

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IPC IPC(8): A61K47/44A61K47/24A61K47/12A61K9/48A61K31/357A61P1/16A61P3/06A61K47/14
Inventor 陈曦侯琬实侯文阁
Owner 侯文阁
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