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Costuslactone composition for preventing skin photoaging and application method thereof

A technology of skin photoaging and woody lactone, applied in skin care preparations, drug combinations, skin diseases, etc., can solve problems such as tumor occurrence, improve skin permeability, enhance skin bioavailability, and inhibit photoaging effect of effect

Active Publication Date: 2014-06-04
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

EGFR is involved in regulating multiple biological processes such as cell proliferation, anti-apoptosis, migration and angiogenesis, and plays a very important role in maintaining normal skin functions, but its abnormal regulation can lead to tumorigenesis. Numerous cancer research results have proved that the inhibition of EGFR Can treat cancer

Method used

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  • Costuslactone composition for preventing skin photoaging and application method thereof
  • Costuslactone composition for preventing skin photoaging and application method thereof
  • Costuslactone composition for preventing skin photoaging and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, anti-light aging test of woody lactone composition:

[0020] After resuscitating a purchased human keratinocyte, expand culture, grow for 3 generations, take half of the cells in a 6cm-diameter petri dish and spread them to a 24-well culture plate, and keep the remaining cells for cryopreservation. After the growth density of cells in the 24-well culture plate reached 60%, they were divided into negative control group, positive control group (all-trans retinoic acid) and experimental group (0.5% corylidene composition, corylidene 1:1 with dehydrocrestolide), add drugs to the positive control group and experimental group respectively, and co-culture for 24 hours. After 24 hours, part of the control group and the experimental group sucked off the medium and added Trizol 500ul for total RNA extraction analysis, pipetting and transferring to a centrifuge tube to freeze to -20°C, the other part of the control group and the experimental group removed the medium,...

Embodiment 2

[0025] Embodiment 2, preparation of anti-photoaging emulsion:

[0026] In the present embodiment, the emulsion formula is as follows:

[0027] (A)

[0028]

[0029] (B)

[0030] Sodium Stearoyl Glutamate 0.20%

[0031] Deionized water to100%

[0032] (C)

[0033]Xanthan Gum 0.50%

[0034] Glycerin 6.00%

[0035] (D)

[0036] Bis(hydroxymethyl) imidazolidinyl urea 0.30%

[0037] Methylparaben 0.20%

[0038] Propylparaben 0.10%

[0039] Preparation method: Heat phases A and B to 80-85 degrees to dissolve completely, then add phase A to phase B for homogenization, and at the same time add phase C which is evenly mixed, homogenize for 5-10 minutes, after homogenization Stir in a water bath and keep warm for 30 minutes, then add other substances in phase D when the temperature drops below 50 degrees, stir evenly, and cool to room temperature.

Embodiment 3

[0040] Embodiment 3, preparation of anti-photoaging moisturizing water:

[0041] The recipe for this implementation is as follows:

[0042]

[0043]

[0044] Preparation method: add the above-mentioned raw materials into sterilized deionized water in sequence, and stir while adding until transparent.

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Abstract

The invention discloses a costuslactone composition for preventing skin photoaging and an application method of the costuslactone composition. The costuslactone composition is prepared by combining costene lactone and dehydro-costuslactone according to a mass ratio of 1: (0.4-2.5); when being used for preparing a cosmetic for preventing skin photoaging, the costuslactone composition can be prepared into lipidosome or nano emulsion with the particle size less than 200nm, and is further added into a cosmetic product. A UVB (Ultraviolet B) induced skin keratinocyte module experiment researches the expression influence of the costuslactone composition on key UVB costuslactone composition photoaging genes, and the experiment result shows that the costuslactone composition can effectively inhibit degradation of collagen and macrophage inflammatory reaction, and an effect of preventing skin photoaging is achieved. The costuslactone composition widely exists in essential oil of a traditional Chinese medicine saussurea costus, and the costuslactone composition can be directly added or the saussurea costus essential oil with the costuslactone composition of a certain ratio can be indirectly added into the cosmetic for preventing skin photoaging.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a woody lactone composition for preventing skin photoaging and its application method. Background technique [0002] Skin photoaging is the premature aging of the skin caused by repeated exposure to the sun's ultraviolet rays. Acute exposure to UV rays from the sun can lead to sunburn (erythema), suppression of the immune system, DNA damage, and degradation of connective tissue, and long-term chronic UV exposure can cause photoaging of the skin, which can lead to skin cancer. With the deterioration of the environment and the reduction of the ozone layer, the amount of ultraviolet radiation irradiating the ground in the sun is gradually increasing, the phenomenon of photoaging of human skin is becoming more and more serious, and the incidence of skin cancer is increasing year by year, which seriously threatens the health of human skin. [0003] Receptor protein tyrosine p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/06A61Q19/08A61P17/18
Inventor 周华锋段明星姜梅高杨严泽民徐之伟
Owner KARLIE COSMETICS MFG CO LTD
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