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Method for detecting and counting blood cell pulse signals based on DSP Builder

A technology of pulse signal and statistical method, applied in the field of blood cell pulse signal detection and statistics, can solve the problems of statistical error of cell number, inaccurate pulse amplitude value, inability to provide diagnostic reference, etc., and achieves high accuracy, high reliability of recognition accuracy, The effect of shortening the development cycle

Inactive Publication Date: 2014-05-28
NINGBO CITY COLLEGE OF VOCATIONAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of the previous detection methods treat the m signal as an abnormal signal; some detections combine the similar differential zero-crossing points of the m signal, and the extracted pulse amplitude value is not accurate, so it cannot provide a correct diagnostic reference; The m signal is split as an M signal, which leads to statistical errors in the number of cells

Method used

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  • Method for detecting and counting blood cell pulse signals based on DSP Builder
  • Method for detecting and counting blood cell pulse signals based on DSP Builder
  • Method for detecting and counting blood cell pulse signals based on DSP Builder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Step 1: Set S N is the sampling value at time N, S N-1 is the sampling value at time N-1, the signal start level C 1 =140mV, the differential lower limit value D=70mV / us in the rising stage at the starting point of the signal;

[0040] signal when S N >C 1 and (S N -S N-1 ) / 1us>D, then point N is the starting point of the signal;

[0041] Step two:

[0042] State A: When the differential value has a maximum value, record the time coordinate as T1=10;

[0043] State B: When the differential value becomes zero or changes from positive to negative, the first peak value of the signal appears, and the recorded value is MAX1=2.8;

[0044] C state: When the differential value becomes zero again or changes from negative to positive, the valley value of the signal appears, and the recorded value is MIN=1.2;

[0045] D state; when the differential value becomes zero for the third time or changes from positive to negative, the second peak value of the signal...

Embodiment 2

[0050] Embodiment 2: Step 1: Set S N is the sampling value at time N, S N-1 is the sampling value at time N-1, the signal start level C 1 =140mV, the differential lower limit value D=70mV / us in the rising stage at the starting point of the signal;

[0051] signal when S N >C 1 and (S N -S N-1 ) / 1us>D, then point N is the starting point of the signal;

[0052] Step two:

[0053] State A: When the differential value has a maximum value, record the time coordinate as T1=15;

[0054] State B: When the differential value becomes zero or changes from positive to negative, the first peak value of the signal appears, and the recorded value is MAX1=2;

[0055] C state: When the differential value becomes zero again or changes from negative to positive, the valley value of the signal appears, and the recorded value is MIN=1.5;

[0056] D state; when the differential value becomes zero for the third time or changes from positive to negative, the second peak value of the signal a...

Embodiment 3

[0061] Embodiment 3: Step 1: Set S N is the sampling value at time N, S N-1 is the sampling value at time N-1, the signal start level C 1 =140mV, the differential lower limit value D=70mV / us in the rising stage at the starting point of the signal;

[0062] signal when S N >C 1 and (S N -S N-1 ) / 1us>D, then point N is the starting point of the signal;

[0063] Step two:

[0064] State A: When the differential value has a maximum value, record the time coordinate as T1=15;

[0065] State B: When the differential value becomes zero or changes from positive to negative, the first peak value of the signal appears, and the recorded value is MAX1=0.6;

[0066] C state: When the differential value becomes zero again or changes from negative to positive, the valley value of the signal appears, and the recorded value is MIN=0.2;

[0067] D state; when the differential value becomes zero for the third time or changes from positive to negative, the second peak value of the signal...

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Abstract

The invention discloses a method and device for detecting and counting blood cell pulse signals based on DSP (Digital Signal Processor) Builder. The detection and the counting of the blood cell pulse signals are implemented on a complex programmable logic device (CPLD) chip by using the DSP Builder according to a digital microparticle signal processing algorithm on the basis of the Coulter principle. According to the invention, characteristic quantities of blood cell signals obtained by a Coulter sensor can be extracted and the classification and identification of four types of pulse signals (single-peak signals, M signals, m signals and abnormal signals) are realized. The method has the advantages that mutant points generated by interference signals can be effectively eliminated, the m signals generated by the edge slip phenomenon can be identified and the M signals generated by horizontal interference (binding phenomenon) can be split. The blood cell quantity counting and the dose-volume histogram counting can be completed while blood samples are efficiently detected. The method disclosed by the invention is suitable for blood cell counting instruments. The method is implemented by adopting the DSP Builder, so that the trouble process for designing the device by using other digital methods is avoided and the design is simplified.

Description

technical field [0001] The invention relates to a blood cell pulse signal detection and statistics method, in particular to a blood cell pulse signal detection and statistics method based on DSP Builder. Background technique [0002] At present, hematology analyzers generally adopt the Coulter principle proposed by the American scientist Coulter in 1947. Coulter's principle states that the amplitude of the voltage pulse generated when the cell particles pass through the charged jewel hole is proportional to the volume of the cell. These voltage pulse signals are amplified, screened and counted, and finally the volume distribution of blood cells can be obtained, which is used by doctors as the basis for diagnosing diseases. [0003] The pulse signal generated by the cells passing through the jewel hole can be roughly divided into single-peak signal and double-peak signal. When only one blood cell passes through the jewel hole vertically and no other cells enter before the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/12
Inventor 雷霞
Owner NINGBO CITY COLLEGE OF VOCATIONAL TECH
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