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Preparation method for novel TiO2 nano crystal whisker materials commonly-loaded with gambogic acid

A technology of nano-whiskers and gambogic acid, which is applied in the field of preparation of nano-drug-loaded particles, can solve the problem of less development of nano-materials, achieve good photocatalytic activity, increase effective concentration, and enhance the effect of targeted and controlled release capabilities

Inactive Publication Date: 2014-05-21
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, research on the combination of nanomaterials and traditional Chinese medicine has been carried out less in China

Method used

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  • Preparation method for novel TiO2 nano crystal whisker materials commonly-loaded with gambogic acid
  • Preparation method for novel TiO2 nano crystal whisker materials commonly-loaded with gambogic acid
  • Preparation method for novel TiO2 nano crystal whisker materials commonly-loaded with gambogic acid

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Experimental program
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Effect test

Embodiment 1

[0030] Example 1: A novel TiO co-carrying gambogic acid 2 The preparation method of nano whisker material, this method comprises the steps:

[0031] The first step: After mixing hydrated titanium oxide and potassium carbonate at a molar ratio of 2:1, the temperature was raised to 810 °C in a muffle furnace for 2 h, and naturally cooled to 20 °C to obtain the prepared potassium titanate (K 2 Ti 2 o 5 ) crude product, the prepared crude product was dried at 60° C. for 24 hours, and 10 g of dried potassium titanate product was taken.

[0032] The second step: use 0.5 mol·L -1 The hydrochloric acid solution will K 2 Ti 2 o 5 Medium K + Ion exchange is complete, and the intermediate product hydrated dititanic acid (H 2 Ti 2 o 5 ·xH 2 O). Among them, K 2 Ti 2 o 5 The molar ratio of the two compounds with hydrochloric acid is 1:2.

[0033] The third step is to pour hydrated dititanic acid into 0.01 mol L-1 glucose solution, wherein the molar ratio of hydrated dititan...

Embodiment 2

[0039] Example 2: A novel TiO co-carrying gambogic acid 2 The preparation method of nano whisker material, this method comprises the steps:

[0040] The first step: After mixing hydrated titanium oxide and potassium carbonate at a molar ratio of 4:1, the temperature was raised to 810 °C in a muffle furnace for 2 h, and then naturally cooled to 20 °C to obtain the prepared potassium titanate (K 2 Ti 2 o 5 ) crude product, the prepared crude product was dried at 60° C. for 24 hours, and 10 g of dried potassium titanate product was taken.

[0041] The second step: use 0.5 mol·L -1 The hydrochloric acid solution will K 2 Ti 2 o 5 Medium K + Ion exchange is complete, and the intermediate product hydrated dititanic acid (H 2 Ti 2 o 5 ·xH 2 O). Among them, K 2 Ti 2 o 5 The molar ratio of the two compounds with hydrochloric acid is 1:2.

[0042] The third step is to pour hydrated dititanic acid into 0.01 mol L-1 glucose solution, wherein the molar ratio of hydrated di...

Embodiment 3

[0044] Example 3: basically the same as Example 1, the difference is: in the third step, in order to remove the carbon generated in the hydrothermal reaction, the C-TiO 2 Calcined in an air atmosphere at 550 °C for 3 h, the new TiO co-loaded with gambogic acid was finally obtained. 2 nanowhisker material.

[0045]

[0046] Beneficial effects of the present invention will be further described in detail through experiments below.

[0047] 1. The present invention obtains nano-whiskers with a new mesoporous structure after high-temperature modification, which effectively improves the specific surface area and mesoporous structure of TiO2 nanomaterials, making the photocatalytic effect of nanomaterials with this structure obvious for different tumor cells enhanced. We used the MTT method to investigate the different concentrations of TiO 2 The toxicity of nano-whisker materials to different types of tumor cells, the results show that when the concentration is lower than 6.25ug...

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Abstract

The invention discloses a preparation method for novel TiO2 nano crystal whisker materials commonly-loaded with gambogic acid. The preparation method comprises the following steps: firstly, mixing hydrated titanium oxide and potassium carbonate and roasting to obtain potassium dititanate; completely exchanging K<+1> ions from the potassium dititanate by a hydrochloric acid liquid to obtain hydrated potassium dititanate; carrying out a hydrothermal reaction on the hydrated potassium dititanate and a glucose liquid; washing and drying in vacuum; and finally, roasting in the air atmosphere of 510-550 DEG C to obtain the product. With the adoption of the preparation method, nano particles with strong photocatalytic effects, small grain diameters, good water dispersibility, high encapsulation efficiency and slow release property can be obtained. A TiO2 nano crystal whisker prepared by the preparation process through adopting a chemical co-precipitation method is a novel anti-tumor preparation integrating chemotherapy, phototherapy and thermotherapy, and has a plurality of advantages of light targeting property, slow release, small side effects and the like, so that the TiO2 nano crystal whisker is the novel anti-tumor preparation which has a very good application prospect.

Description

technical field [0001] The invention relates to a preparation process of nano drug-loaded particles as a drug for treating cancer, specifically a new type of TiO2 co-loaded with gambogic acid 2 Nano-whisker material and preparation method thereof, and preparation of GA-TiO by using the nano-whisker material 2 Methods of nanocomposite drug delivery systems. Background technique [0002] The main means of treating tumors are surgery, radiotherapy and chemotherapy. Although the results are quick, the side effects are very obvious. Due to the severe damage to the body's immunity caused by radiotherapy and chemotherapy, a considerable number of cancer patients cannot adhere to treatment and lose the chance of recovery. Compared with other tumor treatment methods such as biological therapy, the current traditional Chinese medicine treatment of tumors is still relatively backward. As we all know, traditional Chinese medicine is an important part of our country's treasure house o...

Claims

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Application Information

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IPC IPC(8): C30B7/10C30B29/62C30B29/16A61K47/04A61K41/00A61K31/352A61K9/14A61P35/00B82Y30/00B82Y40/00
Inventor 许佩佩欧阳建陈兵
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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