Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Type-I collagen material, meninx and meninge biological membrane and preparation method and application of thereof

A collagen material and biofilm technology, used in the preparation of meninges or meninges, the preparation of dura or meninges tissue repair materials, the meninges or meninges biofilms and their preparation, the field of type I collagen materials, can solve the problem Weak mechanical properties, poor suture performance, neurosurgery limitations, etc., to achieve the effect of prolonging the degradation time

Active Publication Date: 2014-05-21
BEIJING YH BIOMAX BIOLOGIC TECH
View PDF3 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, this porous sponge-like membrane is limited in neurosurgery due to its weak mechanical properties and poor suturing performance during clinical use.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Type-I collagen material, meninx and meninge biological membrane and preparation method and application of thereof
  • Type-I collagen material, meninx and meninge biological membrane and preparation method and application of thereof
  • Type-I collagen material, meninx and meninge biological membrane and preparation method and application of thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1: Preparation of 1.0% meninges / spinal membrane biofilm

[0076] 7.2 grams of high-purity type I medical collagen material with a triple helix structure was used to stir in hydrochloric acid at 10,000 and 18,000 speeds for 30 minutes and 1.5 hours to prepare a 1.% concentration collagen composite suspension. Then use sodium hydroxide to adjust its pH to make it reach the state where the viscosity meets the requirements. Take 500 ml and pour it into a 50X50 cm freezing tray, freeze it for 3 to 4 hours at a low temperature of -60 degrees Celsius, and dry it for 15 hours to make a meningeal / spinal membrane biofilm with a pore size of 60 microns and a thickness of 3 mm.

Embodiment 2

[0077] Embodiment 2: Preparation of 2% meninges / spinal membrane biofilm sheet

[0078] 14.4 g of high-purity type I medical collagen material with a triple helix structure was used to stir at 3,000, 10,000, and 18,000 speeds in hydrochloric acid for 30 minutes, 30 minutes, and 1.0 hour to prepare a collagen composite suspension with a concentration of 2%. Then use sodium hydroxide to adjust its pH to make it reach the state where the viscosity meets the requirements. Thereafter, 100% alcohol was added and stirring was continued for 30 minutes. Take 500 ml and pour it into a 50X50 cm freezing tray, freeze it for 3 to 4 hours at a low temperature of -70 degrees Celsius, and dry it for 20 hours to make a meningeal / spinal membrane biofilm with a pore size of 20 microns and a thickness of 2.5 mm.

Embodiment 3

[0079] Embodiment 3: prepare 2.5% meninges / spinal membrane biofilm sheet

[0080] 18 grams of high-purity type I medical collagen material with a triple helix structure was used to stir at 3,000, 10,00, 18,000 and 28,000 speeds for 15 minutes, 30 minutes, 30 minutes and 1 hour under hydrochloric acid environment to prepare 2.5% concentration Collagen complex suspension. Then use sodium hydroxide to adjust its pH and 100% alcohol to make it reach the state where the viscosity meets the requirements. Stirring was continued for 15 minutes. Take 500 ml and pour it into a 50X50 cm freezing tray, freeze it for 3 to 6 hours at a low temperature of -75 degrees Celsius, and dry it for 25 hours to make a meningeal / spinal membrane biofilm with pores less than 20 microns and 2 mm thick.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
porosityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a type-I collagen material with a high sewing concentration and a tri-helical structure, a meninx and meninge biological membrane prepared from the type-I collagen material, and a preparation method and application of the meninx and meninge biological membrane, and the meninx and meninge biological membrane can be used for the preparation of dura meninx and meninge tissue repair materials.

Description

technical field [0001] The invention relates to the technical fields of medicine, biomaterials, tissue engineering and regenerative medicine, in particular to a type I collagen material, a meningeal or spinal membrane biofilm and its preparation method and application, namely: a collagen fiber with high purity A preparation method and application of high-concentration, high-density, high-strength meninges or meninges made from type I medical collagen materials with a unique triple helix structure. [0002] More specifically, the present invention relates to a high-purity type I collagen material having a triple helix structure, a meninges or meninges biofilm prepared from the type I collagen material and a preparation method thereof, and the meninges Or the application of spinal membrane biofilm in the preparation of dura mater or spinal tissue repair materials. Background technique [0003] With the rapid development of medicine at the end of the 20th century, cell biology...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/50
Inventor 许和平马克·斯拜克许剑懿李登云
Owner BEIJING YH BIOMAX BIOLOGIC TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com