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Bone repair regeneration material and preparation method thereof

A technology for bone repair and composite scaffolds, applied in medical science, prosthesis, etc., can solve the problems of loss of mechanical support, low molecular weight, and decreased mechanical properties of composite materials with hydroxyapatite content, and achieves adjustable pore size and porosity. The effect of uniform distribution of components and excellent biological function

Active Publication Date: 2014-05-14
朱小龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the low molecular weight, low mechanical strength and fast degradation rate of traditional polylactic acid, the mechanical support of the bone defect is lost prematurely before the bone defect is completely repaired, and the final repair fails or achieves a low repair effect.
In the prior art, the invention patent CN100531807C discloses a preparation method of a polylactic acid-based / nano-hydroxyapatite porous composite scaffold material, which first organically modifies the prepared nano-hydroxyapatite, and then modifies the modified The final nano-hydroxyapatite is mixed with polylactic acid. The nano-hydroxyapatite in the porous composite scaffold material of this invention is prepared first and then added to polylactic acid. Although it has been organically modified, it basically belongs to Calcium phosphate is directly blended with polymers to enhance the mechanical properties, but the blending uniformity is poor, and it is difficult to achieve uniform compounding, and the high content of hydroxyapatite is prone to agglomeration, resulting in a decrease in the mechanical properties of the composite material. The strength is better improved

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  • Bone repair regeneration material and preparation method thereof
  • Bone repair regeneration material and preparation method thereof

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preparation example Construction

[0044] The preparation method of the above-mentioned bone repair regeneration material of the present invention comprises the following 5 steps:

[0045] (1) Preparation of calcium phosphate salt composition

[0046] Prepare the powder of the calcium phosphate salt composition, wherein the content of hydroxyapatite is 50-70wt%, and the content of β-tricalcium phosphate is 30-50wt%; preferably, the powder of the calcium phosphate salt composition Prepared by in-situ mixing method, comprising the following steps:

[0047] (1.1) Weigh the calculated amount of calcium nitrate Ca(NO 3 ) 2 and trimethyl phosphate (CH 3 O) 3 PO, dissolved in distilled water and ethanol, respectively;

[0048] (1.2) Then add citric acid C in an equimolar amount to calcium ions in the calcium nitrate aqueous solution 6 h 8 o 7 After fully dissolving, mix the calcium nitrate aqueous solution and the trimethyl phosphate alcohol solution, adjust the pH of the mixed solution to 3-11 with ammonia wa...

Embodiment 1

[0066] A bone repair regeneration material of the present invention is prepared by the following method:

[0067] (1) Preparation of calcium phosphate salt composition

[0068](1.1) Weigh 13.702g (0.0835mol) of calcium nitrate and 7.05g (0.05mol) of trimethyl phosphate according to the Ca / P molar ratio of 1.67, and dissolve them in 80ml of distilled water and 30ml of ethanol respectively;

[0069] (1.2) Add 16.032g of citric acid in an equimolar amount to calcium ions in the calcium nitrate aqueous solution. After fully dissolving, mix the calcium nitrate aqueous solution and the ethanol solution of trimethyl phosphate, and adjust the pH of the mixture to 7.5 with ammonia water. , aging at room temperature for 48 hours; then, drying at 190°C for 2 hours to generate a xerogel;

[0070] (1.3) Calcining the xerogel obtained in step (1.2) at 500°C for 1 hour to obtain the desired nanopowder of calcium phosphate salt composition, wherein the mass percentage of hydroxyapatite is 70...

Embodiment 2

[0084] A bone repair regeneration material of the present invention is prepared by the following method:

[0085] (1) Preparation of calcium phosphate salt composition

[0086] (1.1) Weigh 12.307g (0.075mol) of calcium nitrate and 7.05g (0.05mol) of trimethyl phosphate according to the Ca / P molar ratio of 1.5, and dissolve them in 80ml of distilled water and 30ml of ethanol respectively;

[0087] (1.2) Add 14.400g of citric acid in an equimolar amount to calcium ions in the calcium nitrate aqueous solution. After fully dissolving, mix the calcium nitrate aqueous solution and trimethyl phosphate alcohol solution, and adjust the pH of the mixture to 11 with ammonia water. Aging at room temperature for 48 hours; then, drying at 150°C for 3 hours to generate a xerogel;

[0088] (1.3) Calcining the xerogel obtained in step (1.2) at 600°C for 2 hours to obtain the desired nano-powder of calcium phosphate salt composition, wherein the mass percentage of hydroxyapatite is 50%, β - T...

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Abstract

The invention relates to the technical field of biomaterials, and particularly relates to a bone repair regeneration material and a preparation method thereof. The bone repair regeneration material comprises poly-DL-lactic acid, a calcium phosphate composition and collagen, wherein the calcium phosphate composition comprises hydroxyapatite and beta-tricalcium phosphate. According to the bone repair regeneration material and the preparation method thereof, the poly-DL-lactic acid, the hydroxyapatite-beta-tricalcium phosphate and the collagen are applied to construct the poly-DL-lactic acid / hydroxyapatite-beta-tricalcium phosphate / collagen bone repair regeneration material. The phase size is small and the uniformity is high in a preparation process, so that the prepared material has uniform distribution of material composition, has good biological function and mechanical properties, and provides a three-dimensional adhesion and growth space. The method is simple and safe, low in economic cost and adjustable in pore size and porosity, and the degradation rate of a scaffold can be controlled in a wide range. The bone repair regeneration material is used as a bone tissue engineering scaffold material, and is applied in repair of different kinds of bone tissue defects.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a bone repair regeneration material and a preparation method thereof. Background technique [0002] At present, in the treatment of bone defects caused by trauma, tumor, infection, etc., autologous bone, allogeneic bone and synthetic bone substitute materials are commonly used bone defect repair materials. In specific clinical treatment, autologous ilium bone grafting is the recognized gold standard for bone grafting, but it has disadvantages such as increased trauma for patients, prolonged operation time, limited amount and size of donor bone, and many complications in the donor area. Allograft bone includes allograft bone and xenograft bone. Its preparation and storage costs are high, the preparation method is not standardized, and there are often disadvantages such as immune rejection or bacterial and viral infection. In general, whether it is commonly used autologous bo...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/56A61L27/18A61L27/12
Inventor 朱小龙
Owner 朱小龙
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