Intelligent temperature-sensitive sustained-release gel and preparation method thereof

Abstract

The invention discloses an intelligent temperature-sensitive sustained-release gel and a preparation method thereof. The intelligent temperature-sensitive sustained-release gel comprises the following components in percentage by weight: 15-25 percent basic remedy, in-situ gel material and water, 2-3 percent of poloxamer 188, 0.5-1 percent of polyethylene glycol-6000, 5-7 percent of ornidazole and 60-70 percent of distilled water. An intelligent temperature-sensitive sustained-release in-situ gel drug-loading system is prepared by combining medicaments with different types of high molecular carrier materials, and is applied to root canal treatment for the first time, so that the defects that the lasting time of the conventional root canal disinfecting and sterilizing effects is short, root canals cannot be fully filled with medicaments under the limitation of dosage form and the like are overcome, the root canal disinfecting operation is simplified, and the double effects of sustained-release long-acting treatment and root canal enclosing are achieved. The one-time success rate of root canal treatment is increased, and the intelligent temperature-sensitive sustained-release gel has an important practical value on the treatment of pulposis, pulpitis and periapical periodontitis and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an intelligent temperature-sensitive slow-release gel and a preparation method thereof. Background technique [0002] At present, dental diseases are common in the population, and most people have weak awareness of prevention and treatment, which can easily cause deterioration, lead to deep-seated lesions of teeth, and cause unbearable pain. Common such as pulp disease and periapical disease, the culprit is Bacterial infections. [0003] Root canal therapy is the main treatment for pulp disease and periapical disease in stomatology, and root canal disinfection is an important step in root canal therapy. Root canals treated by mechanical and chemical methods still have some necrotic substances or microorganisms in the deep layer of dentin on the side walls, side branch root canals and around the root apex. In order to further eliminate or reduce microorganisms and promote the heali...

AI Technical Summary

Problems solved by technology

Many studies have shown that FC has systemic toxic and side effects, and the drug will lose its antibacterial ability after being sealed in the root canal for 24 hours under the influence of saliva, blood, plasma, exudate and many bacterial products; calcium hydroxide paste, iodoform Paste, polymer gel, etc. are solid or semi-solid preparations, and the root canal has a small pore size and many fine branches. limited, it is difficult to completely fill the root canal, and the parts that are not sealed with drugs cannot play a role in disinfection and sterilization

[0005] At present, there are many drug administration routes studied at home and abroad: mucosal administration, injection administration, tympanic administration, percutaneous administration, etc., which have not been reported in the field of root canal treatment.