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Drug composition for preventing or treating hypertension

A composition and high blood pressure technology, applied in the field of medicine, can solve problems such as unsatisfactory voltage stabilization effect, blood pressure rise in rats, poor blood pressure reduction effect, etc., and achieve the advantages of product quality control and inspection, improvement of sedative effect, effective dose low effect

Active Publication Date: 2014-05-07
CHENGDU KANGHONG PHARMA CO LTD
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

It was directly decocted and administered to renal hypertensive rats by gavage, and the data showed that the drug composition (crude drug Eucommia: mistletoe = 1:1) had a certain antihypertensive effect, but in the course of administration, the experimental Rats have blood pressure fluctuations and emotional irritability; more obviously, after the drug is stopped, the blood pressure of the rats rises significantly, indicating that the drug formula has poor continuous antihypertensive effect, and the effect of stabilizing blood pressure is not good. ideal

Method used

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  • Drug composition for preventing or treating hypertension
  • Drug composition for preventing or treating hypertension
  • Drug composition for preventing or treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 preparation research of pharmaceutical composition of the present invention

[0030] According to Table 1, take Eucommia and mistletoe medicinal materials with different compatibility ratios, grind them into coarse powder, add 8 times the weight of water (compared to the total weight of the ratio of Eucommia and mistletoe), boil and extract twice, each time for 1 hour, filter , the filtrate was passed through D101 macroporous resin, washed with water until it was basically colorless, then eluted with 3 times 70% ethanol, collected the eluate, concentrated so that the relative density measured at 60°C was 1.05, and dried to obtain the drug combination substance, measure the weight of the pharmaceutical composition, and calculate the yield, the results are shown in Table 1:

[0031] Table 1 Preparation of medicinal materials with different proportions

[0032]

Embodiment 2

[0033] Example 2 Study on Antihypertensive Effect of Prescriptions with Different Compatibility Ratio

[0034] Take 80 spontaneously hypertensive (SHR) rats, male, measure their initial blood pressure, and randomly divide them into 10 groups according to blood pressure, namely model control group, Norwood group, Eucommia group, mistletoe group, drug composition 1, Pharmaceutical Composition 2, Pharmaceutical Composition 3, Pharmaceutical Composition 4, Pharmaceutical Composition 5, and Pharmaceutical Composition 6 (see Table 2 for the proportions of raw materials used in pharmaceutical compositions 1-6, and the preparation method is the same as in Example 1). Among them, the Eucommia group, the mistletoe group, and the pharmaceutical composition 1-6 groups were given a dosage equivalent to 10 g crude drug / kg (converted according to the yield in Example 1) by intragastric administration, and the blood pressure value was measured after 7 days of administration, and the results ar...

Embodiment 3

[0039] The research of different eucommia raw materials (raw product or processed product) in the pharmaceutical composition of embodiment 3

[0040] There are processed and raw products of Eucommia ulmoides in traditional Chinese medicine, and among the processed products, salt-roasted eucommia is a relatively mainstream processed product. The current 2010 edition of "Chinese Pharmacopoeia" includes salt-roasted eucommia. The processing process is as follows: take eucommia pieces or shreds, add vinegar and mix well, stuff them thoroughly, put them in a frying container, fry until the wires are broken, and the surface is burnt black. , let cool.

[0041] In this experiment, self-processed eucommia was prepared by referring to the processing technology of salt-roasted eucommia in the above-mentioned 2010 edition of "Chinese Pharmacopoeia".

[0042] In this experiment, the commercially available processed Eucommia was purchased from Sichuan Derentang Chinese Herbal Pieces Compa...

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Abstract

The invention provides a drug composition for preventing or treating hypertension. The drug composition contains eucommia and mistletoe. The drug composition has a remarkable pressure reducing and stabilizing effect on spontaneously hypertensive rats, and meanwhile has the function of improving hypertensive complications, such as lipid metabolic disease, insomnia, irritability and irascibility.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for preventing or treating hypertension. Background technique [0002] Hypertension is a common and frequently-occurring disease characterized by increased arterial systolic or diastolic blood pressure (140 / 90mmHg), which is caused by a variety of environmental factors, lifestyle and genetic factors. According to the "Guidelines for the Prevention and Treatment of Hypertension in China in 2010", the prevalence of hypertension in my country has gradually increased in recent years, and one out of every five adults suffers from hypertension. It is estimated that at least 200 million people in the country suffer from hypertension . And with the increase of age, the incidence of hypertension gradually increases. According to the survey data on the nutrition and health status of 270,000 residents nationwide organized by the Ministry of Health in 2002, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61P3/06A61P9/12A61P25/20
Inventor 柯潇高小平
Owner CHENGDU KANGHONG PHARMA CO LTD
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