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Antimicrobial peptide effervescent tablets and preparation method and application thereof

An effervescent tablet and antibacterial peptide technology, applied in the field of antibacterial peptide effervescent tablet and its preparation, can solve the problems of increasing the detection rate of pathogenic fungi, affecting the reproductive performance and milk production of dairy cows, economic losses and the like, and achieving Improve the clinical cure rate, increase the antibacterial effect, and save the cost

Inactive Publication Date: 2014-05-07
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the occurrence of endometritis in dairy cows seriously affects the reproductive performance and milk production of dairy cows, causing huge economic losses.
According to preliminary analysis, the increased detection rate of pathogenic fungi may be related to long-term use of antibacterial drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of antimicrobial peptide effervescent tablet, which includes the following raw material components (according to the ratio of raw materials and auxiliary materials for 1000 antibacterial peptide effervescent tablets, the weight of a single tablet is 20g):

[0024] Cecropin 1000g (5% by weight),

[0025] Sodium bicarbonate 5800g (29% by weight),

[0026] Tartaric acid 4200g (21% by weight),

[0027] Polyvinylpyrrolidone 800g (4% by weight),

[0028] Starch 8100g (40.5% by weight),

[0029] Magnesium stearate 100g (0.5% by weight;

[0030] The specific steps are:

[0031] 1) Dry cecropin, sodium bicarbonate, tartaric acid, polyvinylpyrrolidone, starch, magnesium stearate, pass through a 100-mesh sieve, and set aside;

[0032] 2) Weigh the components in step (1), and mix them in equal increments to form a mixture;

[0033] 3) Dissolve polyvinylpyrrolidone in ethanol solution and mix well;

[0034] 4) Spray polyvinylpyrrolidone into the mixture...

Embodiment 2

[0039] The preparation method of antimicrobial peptide effervescent tablet, which includes the following raw material components (according to the ratio of raw materials and auxiliary materials for 1000 antibacterial peptide effervescent tablets, the weight of a single tablet is 20g):

[0040] Cecropin antimicrobial peptide 2000g (10% by weight),

[0041] Sodium bicarbonate 5800g (29% by weight),

[0042] Tartaric acid 4200g (21% by weight),

[0043] Polyvinylpyrrolidone 800g (4% by weight),

[0044] Starch 7100g (35.5% by weight),

[0045] Magnesium stearate 100g (0.5% by weight;

[0046] The specific steps are:

[0047] 1) Dry cecropin, sodium bicarbonate, tartaric acid, polyvinylpyrrolidone, starch, magnesium stearate, pass through a 100-mesh sieve, and set aside;

[0048] 2) Weigh the components in step (1), and mix them in equal increments to form a mixture;

[0049] 3) Dissolve polyvinylpyrrolidone in ethanol solution and mix well;

[0050] 4) Spray polyvinylpyrro...

Embodiment 3

[0055] The preparation method of antimicrobial peptide effervescent tablet, which includes the following raw material components (according to the ratio of raw materials and auxiliary materials for 1000 antibacterial peptide effervescent tablets, the weight of a single tablet is 20g):

[0056] Cecropin 4000g (20% by weight),

[0057] Sodium bicarbonate 5800g (29% by weight),

[0058] Tartaric acid 4200g (21% by weight),

[0059] Polyvinylpyrrolidone 800g (4% by weight),

[0060] Starch 5100g (35.5% by weight),

[0061] Magnesium stearate 100g (0.5% by weight;

[0062] The specific steps are:

[0063] 1) Dry cecropin, sodium bicarbonate, tartaric acid, polyvinylpyrrolidone, starch, magnesium stearate, pass through a 100-mesh sieve, and set aside;

[0064] 2) Weigh the components in step (1), and mix them in equal increments to form a mixture;

[0065] 3) Dissolve polyvinylpyrrolidone in ethanol solution and mix well;

[0066] 4) Spray polyvinylpyrrolidone into the mixture ...

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Abstract

The invention discloses antimicrobial peptide effervescent tablets, which comprise the following components by weight percent: 5-20% of cecropin antimicrobial peptide, 21% of tartaric acid, 15-32% of sodium bicarbonate, 4% of polyvinylpyrrolidone, 25.5-40.5 of starch, and 0.5% of magnesium stearate. The invention also discloses a preparation method of the antimicrobial peptide effervescent tablets and application thereof in treating hysteritis in milk cattle. The antimicrobial peptide effervescent tablets disclosed by the invention use cecropin antimicrobial peptide as a raw material, and have the following advantages: (1) the raw materials are commonly used and easily available, so as to save cost; (2) the process route is simple, so as to be favor of production; (3) due to unique disintegration manner, large contact surface, sustained release and other characteristics, the effervescent tablets for treating hysteritis in milk cattle are suitable for uterus drug delivery, so as to effectively increase drug concentration, improve antimicrobial effect and improve clinical cure rate; and (4) the tablets are convenient to carry and simple in administration, and have rapid action, good stability and other advantages.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to an antimicrobial peptide effervescent tablet and a preparation method and application thereof. Background technique [0002] Cow endometritis is the most common obstetric disease in dairy cows. The morbidity of affected cows is very high, and the course of the disease is long, which seriously affects the milk production and milk quality of dairy cows, and causes serious economic losses to the dairy industry. According to reports, the economic loss caused by cow infertility in the United States is nearly 250 million U.S. dollars every year. It is reported in the UK that endometritis accounts for about 95% of infertile cows, and the incidence of endometritis in cows reported by the former Soviet Union is 34.9%. 39.8%, the incidence of endometritis in dairy cows in my country accounts for 20% to 35%. From 1983 to 1985, the results of a survey of 41 dairy farms in 16 cities includ...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K38/17A61P31/04A61P15/00
Inventor 梁剑平尚若锋王学红陶蕾刘宇郝宝成赵凤舞
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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