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Preparation method of radix bupleuri anti-cold dispersible tablet

A technology of dispersible tablets and Bupleurum bupleurum, which is applied in the field of preparation of Bupleurum anti-cold dispersible tablets, can solve the problems of affecting the full absorption of drugs, difficulty in mastering dosage, and slow dissolution of drugs, so as to achieve good health care function, good anti-cold effect, The effect of convenience

Inactive Publication Date: 2014-04-23
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing cold medicines are mainly in the form of ordinary tablets, granules, and oral liquid preparations. Ordinary tablets often affect the full absorption of the drug due to disintegration and slow dissolution of the drug. Children, the elderly, and patients with inconvenient swallowing have difficulties in taking it. , when the dosage and scale of the drug are large, or the number of tablets taken at one time is large, the problem is more prominent
Although oral liquid preparations are convenient to take, they are less stable and difficult to control the dosage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Extraction of volatile oil of Bupleurum bupleurum: take fresh Bupleurum radix as raw material, add 10 times of water for beating after washing, microwave treatment power 800W for 10 minutes, and then use volatile oil extractor to extract for 5 hours to collect volatile oil.

[0022] 2. 150 parts of Bupleurum; 30 parts of Angelica dahurica; 100 parts of Jujube; 30 parts of Perilla, soaked in water for 15-30 minutes, extracted 3 times with a flash extractor, and the extraction voltage was 100V. , the microwave pretreatment power is 700W, the stirring speed regulator is adjusted to medium speed, the treatment time is 30min, the treatment temperature is 50-55°C, and then 20000U / g of cellulase 0.2%-0.5% (medicine dregs and Angelica dahurica jujube Perilla by weight) for 1-2 hours, centrifuge, concentrate under reduced pressure at 60°C to 2g per milliliter of the original medicinal material, slowly add ethanol until the alcohol concentration reaches 60%, let it stand overni...

Embodiment 2

[0026] 1. Extraction of volatile oil of Bupleurum bupleuri: take fresh Bupleurum radix as raw material, add 9 times of water for beating after washing, microwave treatment power 800W for 10 minutes, then use volatile oil extractor to extract for 5 hours, and collect volatile oil.

[0027] 2. 100 parts of bupleurum; 20 parts of Angelica dahurica; 70 parts of Chinese jujube; 20 parts of perilla, soaked in water for 20 minutes, extracted 3 times with a flash extractor, and the extraction voltage was 90V. The pretreatment power is 800W, the stirring speed regulator is adjusted to medium speed, the treatment time is 10-30min, the treatment temperature is 50-55°C, and then 20000U / g of cellulase 0.2%-0.5% (medicine dregs and Angelica dahurica jujube Perilla by weight) for 1-2 hours, centrifuge, concentrate under reduced pressure at 60°C to 2g per milliliter of the original medicinal material, slowly add ethanol until the alcohol concentration reaches 60%, let it stand overnight, and c...

Embodiment 3

[0031] 1. Extraction of volatile oil of Bupleurum bupleuri: take fresh Bupleurum radix as raw material, add 10 times of water for beating after washing, microwave treatment power 800W for 5 minutes, and then use volatile oil extractor to extract 5 hours to collect volatile oil.

[0032] 2. 50 parts of bupleurum; 10 parts of Angelica dahurica; 30 parts of jujube; 10 parts of perilla, soaked in water for 15 minutes, extracted 3 times with a flash extractor, and the extraction voltage was 100V. The pretreatment power is 600W, the stirring speed regulator is adjusted to medium speed, the treatment time is 10min, and the treatment temperature is 50-55°C, then add 20000U / g cellulase 0.2%-0.5% (medicine dregs and Angelica dahurica jujube perilla % by weight) for 1 to 2 hours, centrifuge, concentrate under reduced pressure at 60°C to 2g of the original medicinal material per milliliter, slowly add ethanol until the alcohol concentration reaches 60%, let it stand overnight, centrifuge t...

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Abstract

The invention discloses a preparation method of a radix bupleuri anti-cold dispersible tablet, and belongs to the technical field of medicine. The tablet is prepared through the following steps: subjecting radix bupleuri volatile oil to a microwave pretreatment, then extracting the radix bupleuri volatile oil by using a volatile oil extractor; obtaining extracts of radix bupleuri, dahurian angelica root, jujube, and perilla through flash extraction and microwave-assisted enzymolysis; then subjecting the extracts to a superfine powder treatment, mixing the extracts with the radix bupleuri volatile oil so as to obtain the main active component; taking starch and dextrin as the filling agent, talcum powder as the lubricant, and lactose, sodium alginate and sodium carboxymethyl starch as the adhesive and disintegrating agent, and finally preparing the dispersible tablet. The tablet is rich in radix bupleuri, has a very good healthcare function, also has the functions of releasing the exterior, dissipating cold, warming the middle, stopping vomiting, protecting liver, draining gallbladder, diminishing inflammation, relieving swelling and pain, eliminating phlegm, and stopping coughing, can treat common cold due to wind-cold, vomiting due to stomach cold, and coughing due to cold phlegm, and has the advantages of scientific formula, user-friendliness, and good anti-cold effect. Furthermore, the preparation technology is reasonable, has strong operability, and can be applied to industrial production.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to a preparation method of Bupleurum anti-cold dispersible tablets. Background technique [0002] The traditional Chinese medicine Bupleurum Chinese DC (Bupleurum Chinese DC) is the dried root of the genus Bupleurum in the Umbelliferae family. Bupleurum soap and Bupleurum volatile oil. Bupleurum Dropping Pills is a pure Chinese medicine preparation made from high-grade Bupleurum chinensis. Bupleurum bupleurum is commonly used to relieve symptoms. Also known as ground smoked, mountain vegetables, mushroom grass, firewood. Bupleurum bupleurum was first recorded in "Shen Nong's Materia Medica" and listed as top grade. There are many descriptions of the plant morphology of Bupleuri in the herbal medicines of the past dynasties. "Bencao Tujing" contains: "(Bupleurum) in Guan, Shaanxi, Jianghu, there are shortcuts, and the one in Yinzhou is the best. The seedlings are born ...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K9/20A61P11/00A61P1/08A61P11/10A61P11/14A61J3/00A61K36/233
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
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