Traditional Chinese medicinal suppository for treating female chronic pelvic inflammation and preparation method thereof
A technology for chronic pelvic inflammatory disease and suppositories, which is applied in the field of traditional Chinese medicine suppositories for treating women with chronic pelvic inflammatory disease and its preparation, which can solve problems such as stubbornness, protracted course of disease, and poor physical fitness of patients, and achieve rapid drug release, symptom relief, and convenient administration Effect
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preparation example Construction
[0053] The preparation steps of the suppository of the present invention are: get 1000g of Salvia miltiorrhiza, 1000g of Andrographis paniculata, 1000g of Caulis Spatholobus, 1000g of motherwort, 1000g of peach kernel, 1000g of Patrinia 1000g, 1000g of Rhododendron 1000g, 1000g of red peony root, 1000g of Ling Xiaohua, 1000g of elderberry, 1000g of dandelion, Scutellaria 1000g, Kochia chinensis 1000g, Qingdai 1000g, Cnidium 1000g, Morus alba 1000g, Cornus officinalis 1000g, raspberry 1000g, white peony 1000g, Sophora flavescens 1000g, Smilax tuckahoe 1000g, soak in water for 30 minutes to 1 hour, heat and boil for 30 minutes ~40 minutes, filter, and the filtrate is set aside; add water to the filter residue, heat for the second time, boil for 30-40 minutes, filter, and set aside the filtrate; add water to the filter residue, heat and boil for the third time for 30-40 minutes, filter; combine the three filtrates , heat and concentrate to a paste, then extract 1000g of Angelica d...
Embodiment 3
[0075] Embodiment 3: Vaginal mucosa irritation test result
[0076] 1. Test method:
[0077] After 3 days of experimental animal quarantine, select 18 above-mentioned healthy rabbits for use, and be randomly divided into three groups, each group of 6, respectively: blank control, excipient control, suppository group of the present invention (5 times concentration by application solution). Sterilized tampons of appropriate size soaked in sterilized physiological saline and the test substance were placed in the vagina of the animals in the vehicle control group and the test substance group, and were in contact with the vaginal mucosa for 6 hours, and the animals were sacrificed 24 hours later. The local vaginal tissue was taken out and the lesion was observed.
[0078] 2. Test results: vaginal mucosa irritation test results
[0079]
Embodiment 4
[0080] Embodiment 4: skin allergy test result
[0081]Use the suppository of the present invention to carry out induction and excitation contact tests, observe the test mice after 24 hours and 48 hours, and there is no phenomenon such as erythema and edema in the skin, and there is no difference with the negative control group. The results show that the suppository has close to zero skin reaction intensity, that is, no skin allergy.
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