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Enema for treating ulcerative colitis and preparation method thereof

A technology for ulcerative colitis and enema, which is applied in the field of medicine, can solve the problems of not paying attention to the treatment of colitis and enema, and achieve the effect of avoiding direct stimulation, avoiding damage, and promoting modernization

Inactive Publication Date: 2014-04-02
吉林修正药业新药开发有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the medical field did not pay attention to the enema treatment of colitis before, there is no enema treatment drug with good curative effect

Method used

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  • Enema for treating ulcerative colitis and preparation method thereof
  • Enema for treating ulcerative colitis and preparation method thereof
  • Enema for treating ulcerative colitis and preparation method thereof

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Embodiment Construction

[0019] 1. Preparation of stock solution: first select the thymus of healthy suckling pigs aged 40-60 days, and place them in a thawing pool for natural thawing. To prepare the colloid mill, rinse the equipment 2-3 times with drinking water and once with purified water. Adjust the optimum grinding gap, turn on the condensed water, add water according to the ratio of mass:volume=1:1 to the porcine thymus raw material and purified water for grinding. Put the ground material into a clean material bucket. After stirring, let the thymus slurry stand still for 2 hours, and put it in a freezer for quick freezing at -12 to -20°C for no less than 36 hours. Thaw the quick-frozen thymus serum naturally and put it into the extraction tank for extraction. Centrifuge the thymus extract in the extraction tank at a rotation speed of 3000-3600r / min. The supernatant is taken, and the supernatant is sterile filtered through an inorganic membrane with a molecular weight cut-off of 50KD, sampled...

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Abstract

The invention provides an active protein enema for treating ulcerative colitis and a preparation method thereof. The enema comprises a group of water-soluble mixed protein with molecular weight of lower than 60KD and medical auxiliaries, wherein the water-soluble mixed protein is extracted from thymuses of suckling pigs. The preparation method comprises the following steps: firstly, selecting thymuses of healthy suckling pigs at age of 40-60 days, thawing, washing with water, adding purified water, grinding, stirring, standing, and quickly freezing for 36 hours at negative 12-negative 20 DEG C; unfreezing, extracting in an extraction tank, centrifuging, taking supernate, aseptically filtering by an inorganic membrane by molecular weight cutoff of 50KD, and collecting the aseptically filtered stock solution in a plasma bottle to obtain a stock solution; dissolving the stock solution and the auxiliaries with injection water to prepare a buffer solution, regulating the pH value, and fixing the volume with injection water to obtain the enema for treating ulcerative colitis. The enema for treating ulcerative colitis has the beneficial effects of directly reaching the focus, relieving diarrhea and diminishing inflammation, improving local blood circulation and metabolism and enhancing the intestinal immunity function, is small in toxic and side effect, remarkable in treatment effect, simple in preparation process and low in cost.

Description

Technical field: [0001] The invention belongs to the field of medicine, and in particular relates to an enema for treating ulcerative colitis and a preparation method thereof. Background technique: [0002] Ulcerative colitis (Ulcerative Colitis, UC), short for chronic nonspecific ulcerative colitis, is a chronic inflammatory disease of the rectum and colon of unknown cause. The main clinical manifestations are diarrhea, mucus pus and blood in the stool, abdominal pain and tenesmus. The severity of the disease varies, and many recurrent outbreaks or long-term delays are chronic processes. [0003] Some people think that ulcerative colitis is an autoimmune disease, and many patients have antibodies that cross-react with normal colonic epithelium and specific intestinal bacterial lipopolysaccharide antigens. Furthermore, lymphocytes cultured with serum from patients with colitis can become cytotoxic to the colonic epithelium. In addition, changes were found in the T and B l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/00A61P1/04A61P1/12A61P29/00C07K1/36C07K1/34C07K14/47A61K35/26
Inventor 杜研高陆白冰张军李庆春于艳辉石菊许艳茹鞠蒙蒙钱好张博学
Owner 吉林修正药业新药开发有限公司
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