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Empty capsule and preparation method thereof

A technology of hollow capsules and glue, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problems of limited applicable population, poor compatibility, and difficulty in disintegration, and achieve low storage requirements, Good compatibility and good stability

Active Publication Date: 2014-03-26
JIANGSU LEFAN CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the currently used hollow capsules are made of gelatin, and the hollow capsules made of gelatin usually have some defects, such as easy hardening, brittleness and difficult disintegration, etc.
In addition, due to the limited source of gelatin, it will react with some drugs and have poor compatibility, and gelatin as a heterologous protein may have antigenicity
In addition, because gelatin is produced from pig bones and pig skin, it is taboo to take it due to religious beliefs, such as Islam and Judaism, so that the capsules made of gelatin are limited to people who are suitable for them.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing a hollow capsule, the hollow capsule is divided into two parts, a cap and a body, and the cap and the body of the prepared hollow capsule are required to be colorless and transparent, and the preparation steps are as follows: 1 part of potassium chloride and 1 part of Sodium lauryl sulfate was dissolved in 182 parts of deionized water, the temperature of the deionized water was controlled at 5°C, then 5 parts of carrageenan was added while stirring, and the remaining 3458 parts of deionized water was heated to 70 ℃ into the above solution, and keep the solution at 80°C for 10 minutes, then add 800 parts of hydroxypropyl methylcellulose while stirring, and finally stir the prepared glue evenly, the stirring speed is 50r / min, and the stirring time 10min, and then defoamed in a 40°C water bath for 10h; then the glue was molded through a dipping mold, and dried for 80min at a temperature of 25°C and a humidity of 35% to obtain a rubber blank. The thic...

Embodiment 2

[0030] A preparation method of a hollow capsule, the hollow capsule is divided into two parts, a cap and a body, and the cap and the body of the prepared hollow capsule are required to be white and opaque, and the preparation steps are as follows: 5 parts of sodium chloride and 2 parts of Sodium lauryl sulfate is dissolved in 500 parts of deionized water, the temperature of the deionized water is controlled at 20°C, then 90 parts of konjac gum is added while stirring, and the remaining 4500 parts of deionized water is heated to 90°C Add to the above solution, and keep the solution at 80°C for 25 minutes, then add 950 parts of hydroxypropyl methylcellulose while stirring, and finally stir the prepared glue evenly, the stirring speed is 75r / min, and the stirring time is 20min , and then defoaming in a water bath at 60°C for 10 hours; then add 4 parts of medicinal titanium dioxide to the glue, the temperature of the glue is 50°C, and the specific gravity of the glue is 1.05g / cm 3...

Embodiment 3

[0032] A preparation method of a hollow capsule, the hollow capsule is divided into two parts, a cap and a body, and the prepared hollow capsule is required to have both a red and transparent cap and a body, and the preparation steps are as follows: 2 parts of potassium chloride and 5 parts of Sodium lauryl sulfate was dissolved in 2112 parts of deionized water, the temperature of the deionized water was controlled at 10°C, then 20 parts of sodium alginate was added while stirring, and the remaining 4223 parts of deionized water was heated to 75 ℃ into the above solution, and keep the solution at 82°C for 15 minutes, then add 850 parts of hydroxypropyl methylcellulose while stirring, and finally stir the prepared glue evenly, the stirring speed is 60r / min, and the stirring time 12min, then defoaming in a water bath at 45°C for 11h; then add 0.6 parts of amaranth, 1.4 parts of carmine and 0.01 parts of brilliant blue to the glue, the temperature of the glue is 40°C, the glue Th...

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Abstract

The invention discloses an empty capsule and a preparation method thereof. The empty capsule is high in stability, good in medicine compatibility and free of mutual effect. The empty capsule disclosed by the invention is low in water content and high in hygroscopicity resistance, so that content is unlikely to cake, and the shell of the capsule is unlikely to deform, harden and crisp for disintegration. The empty capsule has low requirements on storage conditions, does not crisp in low humidity environments and has good stability at a high temperature, and the body of the capsule does not deform. The raw materials of the empty capsule come from non-animal sources, thus no potential risk of accumulated growth hormone or medicine remaining in animals exists, and the empty capsule accords with the requirements of vegetarianism, special culture and religion.

Description

technical field [0001] The invention relates to an auxiliary material for pharmaceutical preparations and a preparation method thereof, in particular to a hollow capsule and a preparation method thereof. Background technique [0002] Capsule preparations are widely used in the field of medicine as an important pharmaceutical dosage form, and hollow capsules are the main auxiliary materials for processing pharmaceutical capsule preparations. Most of the currently used hollow capsules are processed from gelatin, and the hollow capsules made of gelatin usually have some defects, such as easy hardening, brittleness and difficult disintegration. In addition, due to the limited source of gelatin, it will react with some drugs and have poor compatibility, and gelatin may have antigenicity as a heterologous protein. In addition, because gelatin is produced with pig bones and pigskin as raw materials, it is taboo to take it due to religious reasons, such as Islam and Judaism, so tha...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K9/48
Inventor 方忠明刘培勇
Owner JIANGSU LEFAN CAPSULE
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