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A kind of preparation method of matrine molecule surface imprinted polymer material

A polymer material, surface imprinting technology, applied in chemical instruments and methods, organic chemistry, other chemical processes, etc., can solve the problems of affecting the efficiency of solid-phase extraction, poor product performance, complicated preparation process, etc., and achieve good regeneration and circulation. The effect of using performance, excellent binding affinity, and excellent elution performance

Inactive Publication Date: 2016-04-06
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the current methods for preparing alkaloid-imprinted polymer materials are traditional methods, namely the embedding method, which has many disadvantages such as complicated preparation process and poor product performance, which significantly affects the efficiency of solid-phase extraction.

Method used

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  • A kind of preparation method of matrine molecule surface imprinted polymer material
  • A kind of preparation method of matrine molecule surface imprinted polymer material
  • A kind of preparation method of matrine molecule surface imprinted polymer material

Examples

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Effect test

Embodiment 1

[0026] A method for preparing a matrine molecular surface imprinted polymer material of the present invention, the specific steps are as follows: Step 1, preparing functional graft particles SAS-PGMA / SiO 2 :

[0027] ①Add 2.5g of activated silica gel, 125ml of toluene solvent and 2.5mL of coupling agent γ-mercaptopropyltrimethoxysilane (KH-590) into a four-neck flask equipped with an electric stirrer, condensing reflux tube and thermometer, React at 110°C for 12 hours. After the reaction is over, filter with suction. The product particles are washed with toluene, then repeatedly washed with ethanol, and dried in vacuum to obtain modified silica gel particles MPMS-SiO with mercapto groups on the surface. 2 ;

[0028] ②In a four-necked flask equipped with an electric stirrer, a reflux condenser and a thermometer, add 1.2g of modified particles MPMS-SiO 2 , then add 70mL of DMF and 9.9-10.0mL monomer GMA, pass nitrogen for 30min to remove the air in the system, raise the temper...

Embodiment 2

[0035] Step 1, preparation of functional graft particles SAS-PGMA / SiO 2 :

[0036] ①Add 3.0g of activated silica gel, 130ml of toluene solvent and 3.0mL of coupling agent γ-mercaptopropyltrimethoxysilane (KH-590) into a four-neck flask equipped with an electric stirrer, condensing reflux tube and thermometer, React at 110°C for 12 hours. After the reaction is over, filter with suction. The product particles are washed with toluene, then repeatedly washed with ethanol, and dried in vacuum to obtain modified silica gel particles MPMS-SiO with mercapto groups on the surface. 2 ;

[0037] ②In a four-necked flask equipped with an electric stirrer, a reflux condenser and a thermometer, add 1.5g of modified particle MPMS-SiO 2 , then add 70mL of DMF and 10.0mL monomer GMA, pass nitrogen for 30min to remove the air in the system, raise the temperature of the system to 55°C, then add 0.0874g of initiator AIBN, and carry out graft polymerization under constant temperature stirring; A...

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Abstract

The invention provides a preparation method of a matrine molecular surface imprinted polymer material, which can be used to prepare a high-performance matrine molecular surface imprinted polymer material, which uses silica gel as a matrix, has good mechanical properties, and is suitable for industrial production; using matrine as a template molecule and glutaraldehyde as a cross-linking agent, a new molecular surface imprinting technology of "first graft polymerization-post-crosslinking imprinting" was used to prepare a matrine molecular surface imprinted polymer material. There are a large number of matrine imprinted holes distributed in the polymer thin layer, which shows specific recognition selectivity and excellent binding affinity for matrine, excellent elution performance, and good regeneration and recycling performance. This has obvious reference value for effectively separating and extracting pharmacologically active substances from plant tissues.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of alkaloids and molecularly imprinted polymers, and in particular relates to a preparation method of matrine molecular surface imprinted materials. Background technique [0002] Alkaloids are a large class of natural organic compounds widely distributed in a variety of plant tissues, most of which have complex nitrogen heterocyclic structures, have important physiological and pharmacological activities, and are scientifically and efficiently extracted, separated and purified from plant tissues Alkaloids have great application potential in the field of medicine and need to be vigorously developed. Matrine is an alkaloid with significant antitumor, antibacterial, antiviral and other pharmacological activities, mainly derived from leguminous plants Sophora flavescens and Sophora flavescens. As an anticancer drug, matrine has great development value. The crude extract of matrine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/26C08J3/24C08F292/00C08F8/36B01J20/26C07D471/22
Inventor 雷青娟张正国高保娇安富强李延斌曹林交
Owner ZHONGBEI UNIV
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