Omeprazole and sodium bicarbonate core-covering tablet

Abstract

The invention relates to a core-covering tablet containing active ingredients of omeprazole and sodium bicarbonate. The core-covering tablet comprises a peripheral medicine-containing layer (1) and a medicine-containing tablet core (2) located in the middle of the medicine-containing layer, wherein sodium bicarbonate serves as the medicine active ingredient of the peripheral medicine-containing layer (1), while omeprazole serves as the active ingredient of the medicine-containing tablet core (2); the peripheral medicine-containing layer (1) fastens the medicine-containing tablet core (2); the medicine-containing tablet core (2) is coaxial with the core-covering tablet. According to the core-covering tablet, all the active ingredients are nearly not contacted each other, so that the core-covering tablet is high in stability and convenient to process; more importantly, an omeprazole-sodium bicarbonate compound preparation with qualified relevant substances can be gained without strictly controlling intermediate-related substances. Moreover, the sodium bicarbonate layer can be quickly disintegrated to adjust and produce relatively high pH in stomach, and then the omeprazole tablet core is disintegrated under such condition, thus the damage of gastric acid to omeprazole can be reduced.

Description

technical field [0001] The invention relates to a packaged chip, in particular to a packaged chip containing active ingredients of omeprazole and sodium bicarbonate. Background technique [0002] The U.S. FDA has approved the compound immediate-release proton pump inhibitor omeprazole sodium bicarbonate capsules (trade name: Zegerid) from Santarus, with specifications including 40mg / 1100mg and 20mg / 1100mg. The mechanism of action of this compound immediate-release drug is: after oral administration, sodium bicarbonate can cause the pH in the stomach to rise rapidly, thereby protecting the uncoated omeprazole from being degraded by gastric acid in the stomach, which also temporarily stimulates gastric antrum G The cells secrete gastrin. Oral administration of sodium bicarbonate solution can lead to an increase in circulating gastrin levels within 30 minutes. Elevated levels of circulating gastrin stimulate the total number of parietal cells and H+ / K+-ATPase functional molec...

AI Technical Summary

Problems solved by technology

The disadvantages of the above-mentioned capsules are that omeprazole and sodium bicarbonate exist in the same capsule, which has the following disadvantages: 1. The two may come into contact outside the body, which leads to (1) due to the uniformity of multi-component mixing (2) During product testing, it is difficult to determine the content of each component due to mutual interference, which affects the results of qualitative and quantitative analysis; (3) During long-term storage, due to possible chemical compatibility changes between components, it is easy to produce By-products, reducing effects or increasing side effects, product stability is not ideal

2. Because omeprazole and sodium bicarbonate are made into granules, they cause disordered disintegration in the stomach, so that when omeprazole disintegrates, the local part neutralized by sodium bicarbonate has failed

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