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Nanometer biological optical tweezers based on optical micro-flow annular resonant cavity

A ring resonant cavity and bio-light technology, applied in the optical field, can solve problems such as being unable to stand still or move, and achieve low power consumption

Inactive Publication Date: 2014-02-19
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the optical manipulation technology of the ring resonator cannot be really applied at present, because the current configuration of the ring resonator is a non-local manipulation method
Since the photons in the cavity only move around in one direction, their tangential momentum can only provide a one-way driving force for the target particles, causing the particles to be forced to do directional circular motions and cannot be stationary or move to other positions

Method used

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  • Nanometer biological optical tweezers based on optical micro-flow annular resonant cavity
  • Nanometer biological optical tweezers based on optical micro-flow annular resonant cavity
  • Nanometer biological optical tweezers based on optical micro-flow annular resonant cavity

Examples

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Embodiment

[0018] Example: Manipulation experiment of micron-sized polystyrene (polystyrene, PS) pellets.

[0019] 1. Sample production and parameter setting: the preparation scheme is as follows image 3 shown, first, to have a thick SiO 2 The thin film layer (d>2μm) silicon wafer is used as the substrate, and the SiN thin film or polymer SU-8 thin film is prepared as the waveguide layer; and then the annular microcavity structure is prepared by using ultraviolet lithography technology and dry or wet etching technology; Prepare a low refractive index (fluorine-doped compound, such as CYTOP, etc.) upper cover layer, and prepare a phase control electrode in the single-mode waveguide area; use overlay technology to etch the microfluidic channel in the microcavity area; finally, use PDMS to encapsulate the microfluidic channel. flow box.

[0020] 2. Measurement method: firstly, the aqueous solution of micron-sized polystyrene beads is transported into the microfluidic channel; a 1550nm ...

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Abstract

The invention belongs to the technical field of optics and particularly relates to nanometer biological optical tweezers based on optical micro-flow annular resonant cavity. The tweezers comprise a silicon substrate chip type annular micro-cavity and a beam splitter or a multi-mode interference beam splitter. A tunable laser source is used to couple an optical field into the annular micro-cavity through the beam splitter and form an echo wall standing wave mode, and the optical gradient force generated by the standing wave mode is utilized to achieve localization operation of nanometer particles. The optical tweezers have the advantages that the technical bottle neck of nonlocality operation in the prior art is broken through, the features of the micro-flow and the high-quality factor optical micro-cavity are combined, low power consumption is achieved, localization operation of biological molecules in 100 nanoscale is achieved, and the like.

Description

technical field [0001] The invention belongs to the field of optical technology, and in particular relates to a nano-biological optical tweezers based on an optical microflow ring resonant cavity. Background technique [0002] Optical tweezers, as a favorable tool for non-destructive manipulation of biological particles, has been widely used in the fields of cell biology, molecular biology, and medicine since the 1980s. However, with the gradual reduction of the scale of biomedical research objects (from micrometer to nanometer), the traditional focused beam optical tweezers can no longer generate enough gradient force to manipulate nanoparticles. In recent years, researchers have used near-field optical manipulation technology to overcome this difficulty. The so-called near-field optical manipulation is to use the evanescent field generated by light at the device interface by total reflection or metal plasmon resonance to trap or manipulate nanoscale target particles. Sin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02F1/01G02B6/28G21K1/00
Inventor 吴翔李明
Owner FUDAN UNIV
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