Thermo-sensitive gel composition and application thereof

A temperature-sensitive gel and composition technology, applied in medical science, surgery, internal accessories, etc., can solve the problems of inevitable liver ischemia-reperfusion injury, inaccurate partial excavation, and complicated operation, so as to reduce recurrence and improve safety sex, reduce bleeding

Inactive Publication Date: 2014-02-12
王鹏飞 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The fly in the ointment of this method is that although the goal of accurately demarcating the boundaries of liver segments has been achieved, it is still necessary to use the Pringle method to block the first hepatic hilum when cutting the liver parenchyma, whi

Method used

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  • Thermo-sensitive gel composition and application thereof
  • Thermo-sensitive gel composition and application thereof
  • Thermo-sensitive gel composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: rat portal vein injection experiment

[0052] 1. Reagents and Instruments

[0053] Reagents: Poloxamer 407 (P407, BASF, Germany); Indocyanine Green (ICG, Dandong Yichuang Pharmaceutical Co., Ltd.).

[0054] Instruments: collector type constant temperature heating magnetic stirrer (Beijing Medical Equipment Factory); 501 super constant temperature water bath (Beijing Medical Equipment Factory); laser perfusion imager (Moor Equipment Co., Ltd., UK); animal surgical instruments (Shanghai Medical Equipment Co., Ltd.) factory).

[0055] 2. Experimental animals

[0056] Ten healthy male SD rats, weighing 240-260 g, were provided by the Experimental Animal Center of the Academy of Military Medical Sciences. Free access to food and water, 12 hours of lighting, and the experiment began after a week of adaptation.

[0057] 3. Preparation of novel thermosensitive gel and investigation of gelation temperature

[0058] (1) The P407 solution is prepared by cold met...

Embodiment 2

[0069] Embodiment 2: Liver segment resection experiment of Landrace pig

[0070] 1. Reagents and Instruments

[0071] Conventional abdominal surgical instruments (Shanghai, China); SERIE7200 ventilator (USA); monitor (USA); SIMENZ ultrasound machine (USA); ultrasound probe L5-12 (USA); puncture needle (USA); optical microscope (Japan); Blood Biochemical Automatic Analyzer (Germany); TS-12F Biological Tissue Automatic Dehydrator (Hubei, China); CS-Ⅳ Spreading and Slicing Machine (Hubei, China) LEICA RM2016 Paraffin Sectioning Machine (Shanghai, China) LEICA EG1120 Tissue Embedding Machine (Shanghai, China); KD-BL Embedding Machine Freezing Station (Zhejiang, China)

[0072] 2. Experimental animals

[0073] Eighteen healthy male Landrace pigs, weighing 35-40Kg, were provided by the Experimental Animal Center of the General Hospital of the People's Liberation Army and raised in single cages under the conditions of circadian rhythm and automatic room temperature control. Pigs wer...

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Abstract

The invention relates to a thermo-sensitive gel composition. The composition comprises poloxamer segmented copolymer and indocyanine green. A thermo-sensitive gel water solution prepared from the thermo-sensitive gel can be prepared into an intravascular marked disrupting agent which has an excellent bio-compatibility and no toxic or side effect, can temporarily disrupt a target hepatic segment portal venous flow and realize accurate location of hepatic segment and blood vessels. The preparation can be used in clinical application of surgical operations, enables a resection part to be easily identified in an operation while performing disruption, realizes accurate location of the operation, and can greatly reduce the bleeding amount, so that a doctor can complete a resection operation more easily and more safely by means of the preparation, and the operation safety can be improved. The composition is arranged in a kit for preparing the thermo-sensitive gel water solution, can be stored and transported conveniently, and can be used for conveniently preparing the marked disrupting agent for surgical operations. The kit is easy to operate, low in cost and safe and convenient to use.

Description

technical field [0001] The invention belongs to the technical field of thermosensitive gel preparation and its medical application, and in particular relates to a thermosensitive gel composition and its application in surgery. Background technique [0002] At present, surgery has entered the "precision" era. An ideal liver cancer resection should not only completely remove the lesion, but also remove the liver segment where the lesion is located. However, the appearance of the human liver is a whole solid organ, which can be artificially divided into 8 segments according to its internal vascular distribution and blood supply. The key to achieve accurate hepatic segment / sub-segment resection is to demarcate the boundary of the target hepatic segment or sub-segment during the operation, in order to accurately divide a certain liver segment during the operation Currently, there are three commonly used clinical methods: (1) The boundary of the target liver segment is determined...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/14B65D25/10
Inventor 王鹏飞董家鸿李崇辉张爱群蔡守旺
Owner 王鹏飞
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