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Callicarpa nudiflora pellet capsule as well as preparation method thereof

A kind of naked flower purple pearl and pellet technology, which is applied in the field of medicine

Inactive Publication Date: 2014-02-12
许力宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Regarding the nude flower purple pearl, there is no report and clinical application of micropill dosage form at present, because the micropill dosage form can improve the bioavailability or reduce the gastrointestinal irritation caused by the excessive local concentration of the drug, and it can be made into slow and controlled release or Enteric-coated pellets can control the release rate of drugs and other individual advantages, so it is extremely valuable for those skilled in the art to find a formula suitable for the plant extract pellets of Auranthus nudiflora

Method used

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  • Callicarpa nudiflora pellet capsule as well as preparation method thereof
  • Callicarpa nudiflora pellet capsule as well as preparation method thereof
  • Callicarpa nudiflora pellet capsule as well as preparation method thereof

Examples

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specific Embodiment approach

[0057] The present invention will be further described below through specific examples / experimental examples, but it should be understood that these examples and experimental examples are only used for more detailed description, and should not be interpreted as being used to limit the present invention in any form. invention.

[0058] The present invention provides general and / or specific descriptions of the materials and test methods used in the tests. While many of the materials and methods of manipulation which are employed for the purposes of the invention are well known in the art, the invention has been described here in as much detail as possible. It will be clear to those skilled in the art that in the following, unless otherwise specified, the materials and operation methods used in the present invention are well known in the art.

preparation example 1

[0060] Preparation example 1: Take 100kg of the purple pearl of nude flowers, add 1500kg of water, soak for 2 hours, heat and boil for 1 hour, pour out the decoction, add 1500kg of water to the medicinal residues, heat and boil for 90 minutes, combine the two decoctions, filter, and The filtrate was concentrated under reduced pressure to a relative density of 1.14-1.25 (measured at 60°C), and then freeze-dried to obtain the extract of Aurora nudiflora

preparation example 2

[0061] Preparation Example 2: Take 100 kg of the impurity-removed and mashed Auranthus nudiflorum, add 1000 kg of water each time and heat and extract twice, and heat for 1 hour each time; combine the extracts, filter, and concentrate to a relative density of 1.14 to 1.25 (60 ° C heat test) extract, spray-dried into a dry cream powder to get final product.

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Abstract

The invention relates to a callicarpa nudiflora pellet (capsule) as well as a preparation method thereof. The pellet provided by the invention comprises the following components in parts by weight: 30-90 parts of a callicarpa nudiflora extract, 10-75 parts of a diluent, 0.5-10 parts of a disintegrating agent and an optimal binder. The invention further relates to a coating pellet comprising the pellet as well as the preparation method of the pellet. The pellet provided by the invention can be used for preparing a controlled release capsule or an enteric pellet capsule preparation by combining a controlled release or enteric pellet technology. The pellet preparation provided by the invention is reasonable in type and dosage in proportion of the selected main medicines and auxiliary materials, has good yield and has the advantages of stability and safety, high dissolving out rate, high bioavailability, small side effect, and / or convenience in delivery and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a micropill (capsule) of Naked Flower Purple Pearl extract and a preparation method thereof, in particular to Naked Flower which can be used to treat inflammation caused by bacterial infection, acute infectious hepatitis, respiratory tract and digestive tract bleeding Micropills (capsules) made of purple pearl plant extracts and a preparation method thereof. Background technique [0002] Callicarpanudiflora Hook.exArn is a plant of the genus Verbenaceae (Verbenaceae). It is mainly produced in Hainan, my country. It is an authentic medicinal material in Hainan. It is also distributed in Guangdong and Guangxi. Foreign countries are mainly distributed in India, Vietnam and Malaysia. Its roots and leaves can be used as medicine. It has the functions of antibacterial and hemostasis, anti-inflammatory and detoxification, dispersing stasis and swelling, dispelling wind and dampness, etc. Burns a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/16A61K9/48A61P31/04A61P1/16A61P31/20A61P31/14A61P7/04A61P11/00A61P1/00
Inventor 许力宏张宏民
Owner 许力宏
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