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New uses of patchoulone and its derivatives

一种广藿香酮、用途的技术，应用在广藿香酮及其衍生物领域，能够解决产生耐药、副作用大等问题，达到良好抑菌活性、临床应用前景良好、克服致病菌耐药的效果

Active Publication Date: 2015-12-23
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the commonly used drugs for bacterial infectious diseases are antibiotics and broad-spectrum antibacterial drugs, such as imipenem, secondly citioperazone-sulbactam, vancomycin, and secondly nitrofurantoin, which have large side effects and will cause Develop drug resistance, leading to superbugs

Method used

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  • New uses of patchoulone and its derivatives
  • New uses of patchoulone and its derivatives
  • New uses of patchoulone and its derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 Antibacterial activity research of patchouli ketone

[0037] 1 Materials and Instruments

[0038] 1.1 Experimental Instruments

[0039] Multi-point inoculation instrument (Japan Sakuma Manufacturing Co., Ltd., SAKUMAMIT-P type), electric heating constant temperature water bath (Beijing Tonghua Medical Instrument Factory, DSY-1-6 holes), laboratory autoclave (SANYO, MLS-3780 type), CO 2 INCUBATOR (SANYO, MOC-15A), energy-saving purification workbench (Chengdu Xinguang Feilante Purification Engineering Co., Ltd.).

[0040] 1.2 Experimental strains

[0041] Staphylococcus aureus ATCC25923; methicillin-resistant Staphylococcus aureus ATCC43300; Escherichia coli ATCC25922.

[0042] The above standard quality control strains were provided by the Sichuan Antibiotic Industry Research Institute.

[0043] Staphylococcus haemolyticus, Staphylococcus xylosus, Megacoccus erinica, Staphylococcus saprophyticus, Staphylococcus auris, Corynebacterium sicca, Staphylococ...

Embodiment 2

[0066] Example 2 Antibacterial activity research of patchouli ketone in vivo

[0067] 1 Experimental materials

[0068] 1.1 Drugs

[0069] Test drug, patchouli ketone;

[0070] Positive drug, penicillin sodium for injection, specification: 800,000 units, North China Pharmaceutical Co., Ltd., batch number: Y1104101; vancomycin hydrochloride for injection, specification: 500,000 units, Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, batch number: 111204; Cefotaxime sodium for injection, specification: 1.0g, North China Pharmaceutical Hebei Huamin Pharmaceutical Co., Ltd., batch number: XF3120707.

[0071] Modeling drug: Mucinform Porcine Stomach (Type II), specification: 100g, SIGMA-ALDRICH, batch number: 018K0079.

[0072] 1.2 Strains

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PUM

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Abstract

The invention relates to the uses of pogostone (patchoulenone) and its derivatives in the preparation of antibacterial drugs, healthcare food, food, cosmetics, disinfectors or daily chemical articles. The invention also provides a type of antibacterial drug, healthcare food, food, cosmetics, disinfector or daily chemical article. Pogostone has good inhibitory effects on pathogenic bacteria (such as Staphylococcus, etc) or conditional pathogenic bacteria and can be effectively used for treatment of bacterial infectious diseases. Meanwhile, pogostone can also be active against methicillin-resistant bacteria, and thus can be developed as an potential antibacterial agent for clinical therapy.

Description

technical field [0001] The present invention relates to the new application of patchoulone and its derivatives, specifically, the application in the preparation of medicines for treating bacterial infectious diseases. Background technique [0002] Bacterial infectious diseases refer to diseases caused by bacterial infections. Among the common clinical pathogenic bacteria, there are many Gram-negative bacteria, such as Escherichia, Enterobacter, and Pseudomonas bacteria, and there are also Gram-positive bacteria, such as Staphylococcus and Enterobacteriaceae. Bacteria of the genus Coccus. [0003] At present, most of the commonly used drugs for bacterial infectious diseases are antibiotics and broad-spectrum antibacterial drugs, such as imipenem, secondly citioperazone-sulbactam, vancomycin, and secondly nitrofurantoin, which have large side effects and will cause Drug resistance, leading to the emergence of superbugs. Methicillin-resistant Staphylococcus aureus is a kind ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61P31/04A23L33/00
CPCA01N49/00A23L3/3499A23L33/105A61K8/498A61K31/366A61K36/53A61P31/02A61P31/04A61P31/10A61Q17/005Y02A50/30
Inventor 彭成万峰熊亮林大胜
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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