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Photosensitive degradable comb-like copolymer film with controllable surface appearance and performance

A comb-like copolymer and photosensitivity technology, which can be used in medical preparations with non-active ingredients, wave energy or particle radiation treatment materials, medical preparations containing active ingredients, etc., can solve the problem of waste of drugs and resources, low sensitivity, etc. question

Active Publication Date: 2014-01-22
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the past, these means of regulating infiltration relying on fundamental changes in the external environment were not very sensitive, and a lot of drugs and resources were wasted.

Method used

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  • Photosensitive degradable comb-like copolymer film with controllable surface appearance and performance
  • Photosensitive degradable comb-like copolymer film with controllable surface appearance and performance
  • Photosensitive degradable comb-like copolymer film with controllable surface appearance and performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The acid chloride reaction of embodiment 1, CA

[0021] Accurately weigh 14.8170g (100mmol) of CA and add it to a 100ml round bottom flask, add 40ml (550mmol) of thionyl chloride (SOCl 2 ), 20ml dichloromethane (CH 2 Cl 2 ) and five drops of DMF, where CH 2 Cl 2 and DMF as solvent and catalyst respectively, install a reflux system, and heat to reflux for 7 hours under constant temperature oil bath magnetic stirring at 60°C. After the reaction, distill off unreacted SOCl under reduced pressure at room temperature 2 and a solvent, and vacuum-dried at 50° C. for 24 h to obtain the light yellow target product cinnamoyl chloride (CC), with a yield of more than 85%.

Embodiment 2

[0022] Embodiment 2, photosensitive macromonomer (FM n C) Synthesis

[0023] 25 mmol of ε-caprolactone-modified methyl methacrylate FM n (n=1~3) series monomers were dissolved in 10mL of tetrahydrofuran (THF) solvent, and then 2~3mL of triethylamine was added, and 30mmol of CC in THF solution was added dropwise in an ice-water mixture bath, and at room temperature After reacting for 12 hours, the obtained product was filtered, and the filtrate was diluted with anhydrous ether, then washed with 5wt% hydrochloric acid, then 5wt% sodium bicarbonate solution, and finally deionized water twice, and vacuum-dried at room temperature to obtain light yellow target product FM n c.

Embodiment 3

[0024] Embodiment 3, photosensitive comb copolymer PFM n Synthesis of S

[0025] Taking the molar ratio of the three monomers as 1:1:25 as an example, weigh 0.8706g of FMC monomer, 9.3230g of MAPEG macromer and 6.0679g of St monomer into a 100ml round bottom flask, then add 50ml of solvent THF, 0.1550g of initiator AIBN accounting for 1.5% of the total molar ratio of monomers, filled with N 2 After replacement and deoxidation, seal and react in a constant temperature oscillating oil bath at 65°C and 120r / min for 12h to obtain a comb copolymer P(FMC-co-MAPEG-co-St) (hereinafter referred to as PFM n S indicates). The product was precipitated with anhydrous ether, dissolved and precipitated repeatedly 3 times, unreacted monomers were removed, and dried in a vacuum oven at 30°C to obtain a white powder sample. Change the molar ratio of the three monomers, and prepare a series of comb copolymers PFM in the same way n S.

[0026] The resulting copolymer is:

[0027]

[0028...

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Abstract

The invention relates to a photosensitive degradable comb-like copolymer film with controllable surface appearance and performance and belongs to the field of functional polymer materials. Firstly a reaction is carried out on cinnamoyl chloride (CC) and epsilon-caprolactone modified methacrylate (FMn, n is equal to 1-3), so that a series of photosensitive macromolecule monomers (FMnC) are obtained; the FMnC and polyethylene glycol methacrylate (MAPEG) are taken as a first monomer and a second monomer, then free radial copolymerization is carried out on the first monomer, the second monomer and a third monomer such as styrene (St), glycidyl methacrylate (GMA) and tert-butyl methacrylate (BMA), so that a photosensitive degradable terpolymer with a comb-like structure is prepared; a solvent volatilization method is adopted to prepare the product photosensitive degradable terpolymer with the comb-like structure into the film, and study shows that the photosensitive degradable comb-like copolymer film has photosensitivity and degradability; surface appearance and wettability of the photosensitive degradable comb-like copolymer film can be controlled by changing polarity and addition amount of a selective solvent. The obtained photosensitive degradable copolymer film with controllable surface appearance and performance is expected to be taken as an intelligent degradable material and widely applied to the fields of tissue engineering materials, medical materials and the like.

Description

technical field [0001] A photosensitive degradable comb copolymer with controllable surface morphology and properties belongs to the field of functional polymer materials. Background technique [0002] In recent years, comb copolymers are special graft copolymers with different functional groups or segments on their side chains, which have special properties and behave differently from their linear copolymers in solution and melt state. Unique physical properties are getting more and more attention from people. At present, materials with controllable surface wettability and morphology have high application value in the fields of self-cleaning, microfluidics, drug release, drug delivery, bionics, nanoparticle templates, and tissue engineering, and have become a very important research direction. . Among them, the conversion of surface wettability between hydrophilic and hydrophobic through the regulation of external environment such as temperature, light, electricity, and m...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F222/14C08F212/08C08F220/32C08F220/18C08J5/18C08L51/08A61L27/16A61K47/32A61K41/00
Inventor 陈明清杨海鹏施冬健马凤夺于秋彦韩丹
Owner JIANGNAN UNIV
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