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Production method of Sishen Wan preparation

A production method and technology of Sishen Pills, applied in the directions of pill delivery, sugar-coated pills, pharmaceutical formulations, etc., can solve the problems of long production cycle, low production efficiency, coating layer shedding, etc., and achieve short production cycle, high production efficiency, The effect of reducing pollution

Inactive Publication Date: 2014-01-08
LUOYANG SHUNSHI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the traditional pill-making method has many deficiencies, and its main defects are: (1) due to the incomplete pulverization of fibrous medicinal materials, it affects the formation of pills; the dissolution of active ingredients is low, which affects absorption and curative effect; , affect the shape and appearance of the finished pills, and the weight of the pills cannot meet the requirements of the Pharmacopoeia; (3) the production efficiency is low, no more than 10,000 pills per hour; the batch production cycle is long, generally 10-15 days; The dissolution time is long, usually close to 60 or more than 60 minutes; (5) The bioavailability of the pills is low, and the microbial limit cannot meet the requirements of the Pharmacopoeia; (6) The finish of the finished pills is poor, the coating layer is peeling off, and the weight of the pills varies greatly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Accurately weigh 200g of stewed nutmeg, 400g of fried psoralen with salt, 200g of vinegar-made schisandra, 100g of Evodia rutaecarpa, and 200g of pitted jujube, and crush them, pass through a 90-mesh sieve to obtain a fine powder, and mix evenly; take another 200g of ginger , add water and boil to obtain ginger juice, and boil the residue obtained from the ginger to continue boiling for 1 to 2 times to obtain ginger juice, combine the ginger juices obtained each time, and set aside.

[0024] Add the obtained fine powder to the prepared ginger juice and stir evenly to prepare granules with a particle size of 16 mesh, and dry them at 40°C for 10 minutes; then add the granules to a spherical mold and press them into a spherical mold; The spherical mold is added into the pan-pill pan to make pills with a prescribed weight, and dried at 70°C for 9 minutes; the pills are coated to obtain the finished Sishen pill preparation.

Embodiment 2

[0026] Accurately weigh 200g of stewed nutmeg, 400g of fried psoralen with salt, 200g of vinegar-made schisandra, 100g of Evodia rutaecarpa, and 200g of pitted jujube, and crush them, pass through a 100-mesh sieve to obtain a fine powder, and mix evenly; take another 200g of ginger , add water and boil to obtain ginger juice, and boil the residue obtained from the ginger to continue boiling for 1 to 2 times to obtain ginger juice, combine the ginger juices obtained each time, and set aside.

[0027] Add the obtained fine powder to the prepared ginger juice and stir evenly to prepare granules with a particle size of 18 mesh, and dry them at 45°C for 89 minutes; then add the granules to a spherical mold and press them into a spherical mold; The spherical mold is added into the pan-pill pan to make pills with a prescribed weight, and dried at 75°C for 6 minutes; the pills are coated to obtain the finished Sishen pill preparation.

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Abstract

The invention relates to a production method of Sishen Wan preparation. The Sishen Wan includes simmered nutmeg, salted fried psoralen, vinegar Schisandra, Evodia and pitted dates. The production method includes (1) smashing the various raw materials, filtering through 90 to 100 meshes to obtain fine powders; (2) adding water to boil gingers, and obtaining water; (3) stirring the obtained fine powders and the ginger water evenly, preparing as particles with diameter of 15 to 18 meshes, and drying at the temperature of 40 to 48 DEG C; (4) adding the particles to a ball-shaped die to produce ball-shaped molds; (5) adding the ball-shaped molds in to a pill preparing pot to produce pills in prescribed pill weight, and drying at the temperature of 68 to 75 DEG C to obtain the Sishen Wan. The preparing process of the Sishen Wan is short in producing period and high in producing efficiency, the produced pills are easy to shape and smooth on surfaces, and microbiological limits are consistent to stipulations.

Description

technical field [0001] The invention relates to a preparation process of traditional Chinese medicine pills, in particular to a production method of Sishen pill preparation. Background technique [0002] There are many kinds of traditional Chinese medicine preparations, typical ones are capsules, tablets, and pills, and the traditionally commonly used preparations are pills. Sishen Pill is a typical traditional Chinese medicine pill. It is mainly used to treat diarrhea caused by deficiency of kidney yang. Symptoms include borborygmus and abdominal distension, loose diarrhea before dawn, lack of appetite, persistent diarrhea, yellow complexion and cold limbs. Wait. [0003] The traditional process of preparing Sishen Pills is to crush various raw materials and medicinal materials into fine powders of 80-100 mesh; put part of the fine powders into the pan pill pot, add honey water to pan into pellets with a certain particle size, and use a standard sieve to screen the pellets...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K36/9068A61K9/28A61P1/12
Inventor 何广政程爱国
Owner LUOYANG SHUNSHI PHARMA
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