Suction-type ambroxol hydrochloride solution

Abstract

The invention discloses a suction-type ambroxol hydrochloride solution. The suction-type ambroxol hydrochloride solution is characterized in that per 100 mL of menstruum contains 0.15-0.3 g of ambroxol hydrochloride, a surface active agent accounting for 4-6 percent of the ambroxol hydrochloride in mass and a right amount of antioxidant and antiseptic; the pH value of the solution is 4.6-5.8; the menstruum is selected from water for injection, physiological saline and isotonic glucose solution. The suction-type ambroxol hydrochloride solution is sprayed into a patient's mouth, forms mist, directly enters a respiratory tract, is high in suction rate and local condition, realizes the safe and target treatment purpose, and effectively prompts the patient's phlegm to be discharged. Moreover, the suction-type ambroxol hydrochloride solution is low in use amount, high in medical effect, safe, good in stability, low in probability of pollution or oxidative deterioration and long in shelf life.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an ambroxol hydrochloride solution for inhalation. Background technique [0002] Ambroxol hydrochloride is a new generation of respiratory mucus regulator, used for expectorant and cough. The source of ambroxol hydrochloride is Indian natural herbal duckbill flower, and the duckbill flower alkaloid extracted from duckbill flower is molecularly modified to obtain ambroxol hydrochloride. Ambroxol hydrochloride dosage forms listed at home and abroad include oral solutions, tablets, capsules, sustained-release capsules, injections, and freeze-dried powder injections for injection. The administration methods of these dosage forms are oral or injection administration. Injection and oral dosage forms have systemic effects, large adverse reactions, low utilization rate, and even bring certain pain and inconvenience to patients. [0003] The solution for inhalation is sprayed into the mou...

AI Technical Summary

Problems solved by technology

Ambroxol hydrochloride injection directly replaces the atomized inhalation solution dosage form to carry out atomization treatment, and there are many problems as follows: first, lack the uniform standard of drug concentration and course of treatment, clinically use ambroxol hydrochloride injection dosage form to carry out the preparation concentration of atomization inhalation treatment There is no unified standard for the course of treatment, lack of stability and maximization of curative effect

Secondly, lack of safety, ambroxol hydrochloride injection still lacks effective evidence on the safety of the nasal cavity and the whole respiratory system

Finally, the lack of convenience

Ambroxol hydrochloride injection or injection needs to be prepared by adding an appropriate amount of normal saline before aerosol inhalation, which is not convenient for clinical use

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