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Medicament for treating dysmenorrhea and preparation method thereof

A technology for drugs and dysmenorrhea, which can be used in pharmaceutical formulations, drug combinations, drug delivery, etc.

Inactive Publication Date: 2013-12-18
GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above drugs are taken in large doses and take a long time

Method used

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  • Medicament for treating dysmenorrhea and preparation method thereof
  • Medicament for treating dysmenorrhea and preparation method thereof
  • Medicament for treating dysmenorrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Prescription: 160g total flavonoid aglycone of Scutellaria baicalensis, 84g microcrystalline cellulose, 62.48g pregelatinized starch, 21g sodium carboxymethyl starch, 7g crospovidone, 1.75g ​​sodium lauryl sulfate, polysorbate 80 1.22g, talcum powder 4.55g, povidone K 30 8g.

[0143] Process: the dispersible tablet is prepared like this:

[0144] A, take by weighing sodium lauryl sulfate, polysorbate 80 and povidone K 30 Formulated with Povidone K 30 It is a 5% aqueous solution, which is product A;

[0145] B, take by weighing the Scutellaria baicalensis total flavonoid aglycon of 100 mesh sieves, add microcrystalline cellulose, pregelatinized starch and sodium carboxymethyl starch, mix homogeneously in the mixing granulator, get B product;

[0146] C. Mix product A and product B, add 0.06 times the amount of distilled water of product B, stir, granulate, and obtain granules, which is product C;

[0147] D. Take product C and dry it at 70°C for...

Embodiment 2

[0150] Prescription: 170g total flavonoid aglycone of Scutellaria baicalensis, 90g microcrystalline cellulose, 70g pregelatinized starch, 25g sodium carboxymethyl starch, 10g crospovidone, 5g sodium lauryl sulfate, 5g polysorbate 80, Talc powder 5g, Povidone K 30 10g.

[0151] Process: the dispersible tablet is prepared like this:

[0152] A, take by weighing sodium lauryl sulfate, polysorbate 80 and povidone K 30 Formulated with Povidone K 30 It is a 5% aqueous solution, which is product A;

[0153] B, take by weighing the Scutellaria baicalensis total flavonoid aglycon of 120 mesh sieves, add microcrystalline cellulose, pregelatinized starch and sodium carboxymethyl starch, mix homogeneously in the mixing granulator, get B product;

[0154] C. Mix product A and product B, add 1 times the amount of water of product B, stir, granulate, and obtain granules, which is product C;

[0155] D. Take product C and dry it at 80°C for 4 hours. After the dried g...

Embodiment 3

[0158] Prescription: 150g total flavonoid aglycone of Scutellaria baicalensis, 80g microcrystalline cellulose, 60g pregelatinized starch, 15g sodium carboxymethyl starch, 1g crospovidone, 0.1g sodium lauryl sulfate, 0.5 polysorbate 80 g, talcum powder 3g, povidone K 30 1g.

[0159] Process: the dispersible tablet is prepared like this:

[0160] A, take by weighing sodium lauryl sulfate, polysorbate 80 and povidone K 30 Formulated with Povidone K 30 It is a 5% aqueous solution, which is product A;

[0161] B, take by weighing the Scutellaria baicalensis total flavonoid aglycon of 80 mesh sieves, add microcrystalline cellulose, pregelatinized starch and sodium carboxymethyl starch, mix homogeneously in the mixing granulator, get B product;

[0162] C. Mix product A and product B, add 0.03 times the amount of water of product B, stir, granulate, and obtain granules, which is product C;

[0163] D. Take product C and dry it at 60°C for 2 hours. After the drie...

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Abstract

The invention discloses a medicament for treating dysmenorrhea and a preparation method thereof. The medicament is prepared from total flavonoid aglycone of Scutellaria baicalensis, microcrystalline cellulose, pregelatinized starch, carboxymethyl starch sodium, cross-linked polyvinylpyrrolidone, sodium dodecyl sulfate, polysorbate 80, talc and povidone K30. The method is simple and easy to operate; and the product has stable and controllable quality, good efficacy, high safety and little side effect, and can effectively treat dysmenorrhea.

Description

technical field [0001] The invention relates to a medicine for treating dysmenorrhea and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique [0002] Dysmenorrhea is a common clinical disease of menstrual women, frequently-occurring disease, especially about half of adolescent girls suffer from this pain. Dysmenorrhea mostly occurs in the ovulation cycle, while uterine bleeding in the anovulatory cycle is mostly painless. This is because after ovulation, under the action of progesterone, the uterine mucosa in the secretory phase can synthesize more prostaglandin PGF 2α , which stimulates uterine muscle contraction. PGF 2α The content increases, acting on the myometrium and blood vessels, causing strong contraction and pain. Prostaglandin PGF 2α After entering the blood circulation, it can also cause the contraction of the smooth muscle of the gastrointestinal tract, resulting in nausea, vomiting and diarrhea. As the en...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61P15/00
CPCA61K9/0056A61K9/0095A61K9/2054A61K36/539A61P15/00
Inventor 夏文安斯扬蒋坤吴春玲
Owner GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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