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Medicament for allaying fever of child and preparation method thereof

A technology for drugs and children, applied in the field of medicine, can solve the problems of crying and restless children, high difficulty in operation, allergic reactions, etc., and achieve the effect of lasting drug effect, guaranteed treatment effect, and less toxic and side effects

Active Publication Date: 2013-12-11
海门市凤城旅游景点开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral antibiotics in children often cause gastrointestinal reactions, and in severe cases, allergic reactions and other toxic and side effects may also occur. Crying and restless, very uncooperative

Method used

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  • Medicament for allaying fever of child and preparation method thereof
  • Medicament for allaying fever of child and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A medicine for reducing fever in children, which is prepared from the following ingredients in parts by weight:

[0025] Andrographis paniculata 30 parts, Bai Wei 25 parts, honeysuckle 25 parts, forsythia 25 parts, mulberry leaves 20 parts,

[0026] 20 parts of Prunella vulgaris, 18 parts of Albizia Julibrissin, 18 parts of Astragalus, 18 parts of Scutellaria baicalensis, 15 parts of Bupleurum,

[0027] 15 parts of Gongluomu, 15 parts of Chuanxiong, 13 parts of radish, 12 parts of medlar, 12 parts of licorice,

[0028] Pinellia 10 parts, Danshen 10 parts, peach kernel 7 parts, osmanthus twig 7 parts, red peony root 5 parts, dried ginger 5 parts, bamboo leaves 3 parts.

[0029] Its preparation method is as follows:

[0030] Take andrographis paniculata, Baiwei, honeysuckle, scutellaria baicalensis, pinellia baicalensis, salvia miltiorrhiza, peach kernel, and cassia twig according to the above weight parts (proportioning unit is gram), mix evenly, add 5 times the weight...

Embodiment 2

[0034] 1. Toxicity test:

[0035] In this experiment, healthy SD rats were used, and the dose gradient of the drug prepared in Example 1 was administered orally at 0.1 mg / kg and 0.5 mg / kg, and the drug was administered continuously for 30 days. Animal growth status, activity diet, hematology, blood biochemistry, organ tissue structure and urine routine were not significantly affected, indicating that the clinical medication is safe and reliable.

[0036] 2. Analgesic experiment:

[0037] The effect on the writhing reaction induced by acetic acid in BALB / c mice: 60 BALB / c mice, half male and half male, with an average body weight of 25.7 g, were randomly divided into two groups, namely the normal saline group and the drug group of Example 1; Administer once a day, the dose is 0.25mg / kg (the experimental group is given the drug, the control group is given the same weight of normal saline), and it is administered by intragastric administration for 3 consecutive days. Acetic aci...

Embodiment 3

[0047] clinical effect

[0048] Case type: A total of 70 cases, including 33 males and 37 females, aged 8 months to 4 years, with an average age of 2 years and 3 months. They were randomly divided into two groups, 35 people in each group. The first group took the medicine prepared in Example 1, and the second group took the ibuprofen suspension (Tianda Pharmaceutical Co., Ltd.).

[0049] Clinical symptoms: Cold symptoms such as nasal congestion, runny nose, and cough due to exogenous wind and cold, body temperature 38.1°C-40.2°C, the patient's face is red, ears are red, and crying is restless.

[0050] Therapeutic method: two groups are on the basis of conventional treatments such as antibacterial, antiviral, replenishing liquid, physical cooling, etc., and experimental group, take the medicine prepared in embodiment 1, three times a day, take after meal, each 5mg; Control group each 0.25 ml / kg, three times a day, the course of treatment is 3 days.

[0051]Criteria for evalu...

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Abstract

The invention relates to a medicament for allaying a fever of a child, and a preparation method thereof. The medicament is prepared from 30 parts of herba andrographitis, 25 parts of blackend swallowwort root, 25 parts of honeysuckle, 25 parts of fructus forsythia, 20 parts of folium mori, 20 parts of selfheal, 18 parts of cortex albiziae, 18 parts of astragalus membranaceus, 18 parts of scutellaria baicalensis, 15 parts of radix bupleuri, 15 parts of Chinese mahonia stem, 15 parts of ligusticum wallichii, 13 parts of semen raphani, 12 parts of fruit of Chinese wolfberry, 12 parts of liquorice, 10 parts of pinellia ternate, 10 parts of root of red-rooted salvia, 7 parts of peach kernel, 7 parts of cassia twig, 5 parts of root of common peony, 5 parts of rhizoma zingiberis and 3 parts of bamboo leaves. The medicament treats both symptoms and root causes aiming at the fever of the child, is free of poison and harm to a human body, free of side effect, low in price, and simple and convenient to prepare, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for reducing fever in children and a preparation method thereof. Background technique [0002] Traditional Chinese medicine believes that children are not full, their muscles are thin, their defense functions are weak, and they have not been able to adapt well to climate changes, so they are easy to be invaded by external pathogens and cause fever. Modern medicine believes that fever is a response of the human body to resist diseases. The pathogenic microorganisms that cause fever in young children mainly include bacteria, viruses, mycoplasma, and chlamydia. The exact pathogenesis is not completely clear, it is the result of a combination of many factors, and low immune function is considered to be one of the important causes of the disease. In the prior art, the research on the treatment method of fever in children is roughly (1) physical cooling, such a...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P29/00
Inventor 王怀珍
Owner 海门市凤城旅游景点开发有限公司
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