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Etoposide implant

A technology for etoposide and implants, applied in the size, shape, composition, release characteristics and preparation of etoposide implants, etoposide implants and the fields of their preparation, can solve the problem of many prescription components, Complex process and other problems, to achieve the effect of less systemic adverse reactions, simple preparation process and long validity period

Active Publication Date: 2013-12-04
合肥中人科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Etoposide is a water-insoluble drug. To prepare sustained-release implants by this method, it is necessary to add a surfactant with excellent performance to promote dissolution and add a porogen to promote its diffusion. The prescription has many ingredients and the process is complicated.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 prepares etoposide implant (A)

[0047]

[0048] Crush the above materials respectively, pass etoposide and polylactic acid through a 120-mesh sieve, and polyethylene glycol pass through a 200-mesh sieve, weigh and mix according to the prescription amount, 5 g in total, mix evenly in a mixer, and oscillate into a glass with an aperture of 0.9 mm. In a 141-hole stainless steel mold, put it in a ZR-II drug pressing machine (developed by Anhui Zhongren Technology Co., Ltd.), press to form at 320Mpa, and demould, to obtain the etoposide implant (A).

[0049] The implant is easy to demold, has a smooth surface, a diameter of 0.9mm, a length of 1.2mm, a strength of 5.6MPa, and 90% of the drug release time is 10 days, see Example 4 and figure 1 .

Embodiment 2

[0050] Embodiment 2 prepares etoposide implant (B)

[0051]

[0052] Except that the pressure of the medicine pressing machine was 410Mpa, the rest of the preparation process was the same as in Example 1 to obtain the etoposide implant (B).

[0053] The implant is easy to demold, has a smooth surface, a diameter of 0.9mm, a length of 1.9mm, a strength of 9.5MPa, and a 90% release time of 36 days, see Example 4 and figure 1 .

Embodiment 3

[0054] Embodiment 3 prepares etoposide implant (C)

[0055]

[0056] Except that the pressure of the medicine pressing machine was 480Mpa, the rest of the preparation process was the same as in Example 1 to obtain the etoposide implant (C).

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Abstract

The invention relates to an etoposide implant, and a preparation method, purpose and an application method thereof. The implant is a circular column with diameter of 0.2-1.2 mm and length of 1-5 mm; and the implant is prepared from etoposide, polylactic acid and polyethylene glycol through compacting. It takes the implant 6-120 days to release 90% of the medicine in human body; and the implant can be implanted into a tumor focus through medicine implant needle percutaneous puncture or surgery, or implanted into positions requiring long-time etoposide medication treatment for regional continuous long-time medicament treatment.

Description

technical field [0001] The invention relates to an etoposide implant and a preparation method thereof, in particular to the composition, shape, size, release characteristics and preparation method of an etoposide implant. [0002] The present invention also relates to the application and application method of the etoposide implant. Background technique [0003] Etoposide is a commonly used clinical antineoplastic drug, which is a cell cycle-specific drug that acts on late S phase and G phase. 2 In the early stage, its action site is topoisomerase II, forming a stable cleavable complex among the product, enzyme and DNA, interfering with the function of DNA topoisomerase II, making it difficult to repair DNA after damage. Since the combination of this product and DNA topoisomerase is reversible, it acts on the longer-lasting S phase and G phase in the cell cycle. 2 Therefore, the higher the blood concentration and the longer the duration of conventional oral or blood adminis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/22A61K9/70A61K31/7048A61K47/34A61P35/00
Inventor 王世亮许健健周浩炳叶红杨尹情胜陈殿良马建华徐德钧宣尔康周丽春邵娟杜军
Owner 合肥中人科技有限责任公司
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