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Reaction separating and coupling apparatus, and technology for preparation of gluconic acid from xylitol crystallization mother liquor

A technology of crystallizing mother liquor and gluconic acid, which is applied in bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, biochemical cleaning device, etc. problems, to achieve the effect of reducing purification steps, simplifying separation steps, and improving production efficiency

Inactive Publication Date: 2013-11-27
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent CN101538591A: Method for preparing gluconic acid from xylose crystallization mother liquor, reports a method for preparing gluconic acid by using xylose crystallization mother liquor, but the reaction process and separation process of gluconic acid preparation are separated, that is, after the reaction can be obtained from Separating and refining gluconic acid from the reaction solution, the steps are cumbersome, energy-consuming and the yield is not high

Method used

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  • Reaction separating and coupling apparatus, and technology for preparation of gluconic acid from xylitol crystallization mother liquor
  • Reaction separating and coupling apparatus, and technology for preparation of gluconic acid from xylitol crystallization mother liquor

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Embodiment 1

[0034] figure 1 As a specific embodiment of the present invention, as can be seen from the figure, the reaction separation coupling device for preparing gluconic acid from xylitol crystallization mother liquor includes co-immobilized glucose oxidase and catalase column reactor 7, Nanofiltration device 3, two fixed-bed chromatography columns 8, computer control system 11, three transfer pumps 2, raw material liquid storage tank 1, product liquid storage tank 9, eluent liquid storage tank 10, five valves 4, Three three-way valves 5, five four-way valves 6. as attached figure 1 shown.

[0035] The top of the nanofiltration device 3 is connected to the liquid storage tank through the pump 2a, and one end of the bottom liquid outlet (nanofiltration decolorization solution) is connected to the bottom of the co-immobilized glucose oxidase and catalase column reactor 7, and the other end retains The liquid outlet is connected with the circulation main pipeline and connected with th...

Embodiment 2

[0052] First, according to figure 1 device, the nanofiltration membrane with a molecular weight cut-off of 4000Da is placed in the nanofiltration device 3, and the co-immobilized CAT / GOD cross-linked chitosan is filled in the co-immobilized glucose oxidase and catalase column reactor 7 Lysine resin, filled with anion exchange resin D239 in two chromatography columns 8.

[0053]In the second step, through the transfer pump 2a, the xylose crystallization mother liquor enters the nanofiltration device 3, and one end of the nanofiltration device outlet (nanofiltration decolorization solution) is connected to the bottom of the co-immobilized glucose oxidase and catalase column reactor 7 , to provide the xylose crystallization mother liquor that meets the requirements, and the intercepted liquid at the other end is connected to the main circulation pipeline and connected to the raw material liquid storage tank 1.

[0054] The third step is to set the appropriate CAT / GOD enzyme acti...

Embodiment 3

[0062] First, according to figure 1 The device with a molecular weight cut-off of 5000Da is placed in the nanofiltration device 3, and the co-immobilized CAT / GOD cross-linked chitosan is filled in the co-immobilized glucose oxidase and catalase column reactor 7 Lysine resin, filled with anion exchange resin D239 in two chromatography columns 8.

[0063] In the second step, through the transfer pump 2a, the xylose crystallization mother liquor enters the nanofiltration device 3, and one end of the nanofiltration device outlet (nanofiltration decolorization solution) is connected to the bottom of the co-immobilized glucose oxidase and catalase column reactor 7 , to provide the xylose crystallization mother liquor that meets the requirements, and the intercepted liquid at the other end is connected to the main circulation pipeline and connected to the raw material liquid storage tank 1.

[0064] The third step is to set the appropriate CAT / GOD enzyme activity temperature in the ...

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Abstract

The invention provides a reaction separating and coupling apparatus, and a technology for preparation of gluconic acid from xylitol crystallization mother liquor. The reaction separating and coupling apparatus comprises a nanofiltration device, a co-immobilization glucose oxidase and catalase column reactor; a fixed bed chromatography column, a computer control system, a transmission pump, a raw material liquid storage tank, a product liquid storage tank, an eluate storage tank, and valves. Reaction coupling of the co-immobilization glucose oxidase and catalase column reactor and adsorption processes of the fixed bed chromatography column is realized for the first time, so that a gluconic acid solution containing a large amount of impurities is prepared from xylitol crystallization mother liquor by the immobilization enzyme column reactor, and is delivered into the fixed bed chromatography column directly, and production of high purity gluconic acid with selectivity is realized. Production efficiency of gluconic acid from xylitol crystallization mother liquor is increased; feedback inhibition is eliminated; the value of industrial waste is increased; and reaction, solid-liquid separation and purification are combined by the reaction separating and coupling apparatus, and the technology. The obtained gluconic acid is colorless crystals, yield is of 84 to 95%, and purity can reach 94 to 97%.

Description

1. Technical field [0001] The invention belongs to the technical field of biochemical industry, and in particular relates to a reaction separation coupling device and a process for preparing gluconic acid from xylitol crystallization mother liquor. 2. Background technology [0002] Xylitol is a natural low-calorie new functional sweetener and high-grade food therapy product extracted from birch, oak, corn cob, bagasse and other plants. It has the functions of lowering blood fat, resisting ketone bodies, and maintaining normal bone density. . Chemical hydrolysis hydrogenation crystallization method is the main method of producing xylitol at present. Usually, the production of xylose is accompanied by the production of a large amount of crystallization mother liquor, which contains about 75% of the total sugar concentration. Due to the repeated use of the crystallization mother liquor, the miscellaneous sugars remaining in the mother liquor, such as glucose and arabinose, gr...

Claims

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Application Information

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IPC IPC(8): C12M1/38C12M1/34C12M1/12C12P7/58
Inventor 王丹王洪辉汪楠王競周小华
Owner CHONGQING UNIV
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