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A copper-containing intrauterine device

An intrauterine device and IUD technology, which is applied to female contraceptives and other directions, can solve problems such as low conversion rate of divalent copper ions, and achieve the effects of uniform surface energy, simple method and light burst release degree.

Active Publication Date: 2015-09-23
吴江永元生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide an intrauterine device containing ultrafine-grained copper, which overcomes the sudden release of copper ions in the uterine cavity of the existing copper-containing intrauterine device at the initial stage of implantation and the resulting side effects On the other hand, it overcomes the problem of low conversion rate of divalent copper ions in the long-term use of the existing copper-containing IUD, and enhances the long-term contraceptive effect of the copper-containing IUD

Method used

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  • A copper-containing intrauterine device
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  • A copper-containing intrauterine device

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Effect test

specific Embodiment 1

[0036] The ultra-fine crystal copper tube T-shaped intrauterine device of the present invention is composed of a mixture support 1 of high pressure polyethylene and barium sulfate and an ultrafine crystal copper tube 2 (such as Figure 8 ), where the total area of ​​ultra-fine grained copper tubes is 220mm 2 . Soak the ultra-fine-grained copper tube T-shaped intrauterine device in the simulated uterine cavity fluid at 37°C for 150 days, and the release rate curve of copper ions is as follows: image 3 shown. At the initial stage of immersion, 220mm 2 The ultra-fine-grained copper tube showed a certain burst release of copper ions, but the burst release amount was from 119.35→19.37μg / day, and the burst release time was the first 15 days of immersion, which is comparable to that of the existing coarse-grained copper uterus with the same area. Compared with the IUD, the burst release time (20~30d) was shortened, and the burst release amount (263.62→36.37μg / day) was reduced. A...

specific Embodiment 2

[0038] The non-support Gini fixed intrauterine device of the present invention is made up of the ultra-fine-grained copper rod 4 that the central axis has aperture by medical operation thread 3 (such as Figure 9 ), where the total area of ​​ultra-fine grained copper rods is 300mm 2 . The stent-free Gini fixed IUD was soaked in the simulated uterine cavity fluid at 37°C for 150 days, and the release rate curve of copper ions was as follows: image 3 shown. The increase in the area of ​​the ultra-fine-grained copper material did not significantly increase the copper ion burst release of the IUD. The copper ion burst release completed in the first 15 days changed from 125.79 to 20.75 μg / day, and the copper ion release after long-term immersion was stable. The average release rate was 3.1 μg / day. Compared with the burst release amount (328.89→39.01μg / day), burst release time (about 30d) and long-term copper ion release rate (about 1.54μg / day) of the coarse-grained copper IUD w...

specific Embodiment 3

[0039] The specific steps of the platelet adhesion test are as follows:

[0040] 1) Collect fresh healthy human blood for anticoagulation to make ACD whole blood, centrifuge for 15min, and the centrifuge speed is 2000rpm;

[0041] 2) Remove the platelet-rich plasma in the upper layer after centrifugation, soak the sample in it, and place it in a constant temperature water bath at 37°C for 1 hour;

[0042] 3) Take out the sample, rinse it with normal saline, and then fix the platelets adhering to the surface of the sample with 2.5% glutaraldehyde solution for 1 h;

[0043] 4) The samples were dehydrated step by step in ethanol solutions with concentrations of 30%, 50%, 70%, 90% and 100%, respectively, and the dehydration time of each stage was 15 minutes;

[0044] 5) dealcoholize step by step with isovaleraldehyde acetate whose concentrations are respectively 30%, 50%, 70%, 90% and 100%, and the dealcoholization time of each stage is also 15 minutes;

[0045] After the sample...

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Abstract

The invention relates to an intrauterine device for a female, in particular to a novel birth control device containing an ultrafine crystal copper block material as a birth control active material. A copper-containing part of the copper-containing intrauterine device is made of a blocky copper material with ultrafine crystal structural characteristics. The ultrafine crystal copper block material is a blocky ultrafine crystal copper material with the purity of over 99.96 percent. The copper-containing intrauterine device is a copper-containing intrauterine device or a copper-containing and medicament-containing intrauterine device. The copper-containing intrauterine device is a stent type intrauterine device or a stentless intrauterine device. The copper-containing part of the intrauterine device is machined into a copper wire, a copper tube or a copper rod. According to the technical scheme, the conventional clinically used coarse crystal copper block material in the copper-containing intrauterine device and the copper-containing and medicament-containing intrauterine device are replaced by the ultrafine crystal copper block material with the purity of over 99.96 percent, and the corrosion uniformity of the ultrafine crystal copper block material is higher than that of the conventional coarse crystal copper in uterine luminal fluid.

Description

technical field [0001] The invention relates to an intrauterine contraceptive device for women, in particular to a novel contraceptive device containing ultra-fine-crystalline copper block material as a contraceptive active substance. Background technique [0002] The intrauterine device has become the most safe, effective, simple, economical and reversible birth control method, and it occupies an important position in the world, especially in my country. After nearly half a century of development, the copper-containing intrauterine device is widely used clinically at present, and the active material with birth control effect is a copper block material. Copper block materials can be processed into wires, rods, tubes, etc., attached to inert polymers, bio-stainless steel, shape memory alloy stents or inert polymer wires, and implanted into the female uterine cavity. The uterine cavity fluid interacts slowly for a long time, corrodes, and releases divalent copper ions to achi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F6/14
Inventor 饶永
Owner 吴江永元生物科技有限公司
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