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Magnetic composite microsphere as well as preparation method and application thereof

A technology of magnetic composite microspheres and microspheres, which is applied in the preparation of microspheres, microcapsule preparations, and the magnetism of organic materials/organic magnetic materials. It can solve the problems of lack of specific functional groups, small specific surface of magnetic microspheres, There are many preparation procedures to achieve the effect of convenient operation, simple equipment and high separation efficiency

Inactive Publication Date: 2013-10-16
NINGXIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Analysis of the above-mentioned preparation process and experiments shows that there are some deficiencies in this invention: (1) the secondary initiation of polymerization is adopted, and the preparation procedure is many, and the process is long
(2) The specific surface of the prepared magnetic microspheres is very small and lacks specific functional groups, which is not conducive to the application in biomedicine, especially in the fields of immobilized enzymes and cell separation.
Patent CN1105741C provides a mesh-type sieve plate vibrating suspension polymerization reaction device, which includes the reaction kettle, oil phase storage tank and water phase storage tank in the conventional polymerization reaction device, and is also equipped with a dispersion tower, and the equipment is complicated

Method used

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  • Magnetic composite microsphere as well as preparation method and application thereof
  • Magnetic composite microsphere as well as preparation method and application thereof
  • Magnetic composite microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Disperse 1.0g of glycidyl methacrylate, 3.0g of cross-linking agent divinylbenzene, 0.8g of initiator dibenzoyl peroxide and 2.5g of ferric iron tetroxide nano-magnetic powder in 200ml of acetonitrile solvent, ultrasonic Disperse, mix evenly and transfer to a reaction device equipped with a fractionating column, a condenser tube and a liquid contact bottle, heat slowly until the solution boils and maintain a constant temperature, the solution gradually becomes turbid and the solvent begins to evaporate, and the polymerization time is controlled to stop the reaction within 2 hours. The obtained magnetic composite microspheres were separated from the solvent in a magnetic field, washed three times with tetrahydrofuran, acetone, and anhydrous ether, and dried in a vacuum oven at room temperature. The specific saturation magnetization of the prepared magnetic composite microspheres is 46.8emu / g, the surface active epoxy group content is 0.82mmol / g, and the hydrolysis activit...

Embodiment 2

[0028] Disperse 1.0g of glycidyl methacrylate and 3.0g of crosslinking agent ethylene glycol dimethacrylate and 0.8g of initiator azobisisobutyronitrile and 2.0g of ferroferric oxide nano-magnetic powder in 200ml of acetonitrile In the solvent, ultrasonically disperse, mix evenly and then transfer to the reaction device equipped with a fractionation column, a condenser tube and a liquid contact bottle, heat slowly until the solution boils and maintain a constant temperature, the solution gradually becomes turbid and the solvent begins to evaporate, and the polymerization time is controlled at 4h Stop responding. The obtained magnetic composite microspheres were separated from the solvent in a magnetic field, washed three times with tetrahydrofuran, acetone, and anhydrous ether, and dried in a vacuum oven at room temperature. The prepared magnetic composite microspheres had a specific saturation magnetization of 38.8emu / g, a surface active epoxy group content of 0.67mmol / g, and...

Embodiment 3

[0030] Disperse 2.0g of glycidyl methacrylate, 2.0g of cross-linking agent divinylbenzene, 1.2g of initiator dibenzoyl peroxide and 2.5g of ferric iron tetroxide nano-magnetic powder in 300ml of acetonitrile solvent, ultrasonic Disperse, mix evenly and transfer to a reaction device equipped with a fractionating column, a condenser tube and a liquid contact bottle, heat slowly until the solution boils and maintain a constant temperature, the solution gradually becomes turbid and the solvent begins to evaporate, and the polymerization time is controlled to stop the reaction within 2 hours. The obtained magnetic composite microspheres were separated from the solvent in a magnetic field, washed three times with tetrahydrofuran, acetone, and anhydrous ether, and dried in a vacuum oven at room temperature. The prepared magnetic composite microspheres had a specific saturation magnetization of 42.6emu / g, a surface active epoxy group content of 0.97mmol / g, and a hydrolytic activity (A)...

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Abstract

The invention discloses a magnetic composite microsphere as well as a preparation method and an application thereof. The magnetic composite microsphere has an autologous active epoxy group with the content ranging from 0.1 mmol / g to 2.0 mmol / g, the diameter of the magnetic composite microsphere ranges from 50 nm to 150 nm, the magnetic composite microsphere is regularized, Fe3O4 nano particles are packaged in a network structure of a polymer, the content of Fe3O4 in the microsphere accounts for 20%-70%, and the specific saturation magnetization ranges from 20 emu / g to 60 emu / g. Simultaneously, the preparation method of the magnetic composite microsphere is provided, the method is mild in condition, convenient to operate and simple in device; and the prepared magnetic composite microsphere can covalently bind biomolecules through the autologous active epoxy group, can rapidly settle under the action of a magnetic field, and has high separation efficiency, low cost, simple process and industrialized application value.

Description

technical field [0001] The invention belongs to the technical field of composite polymer functional materials, and relates to a magnetic composite microsphere and its preparation method and application. Background technique [0002] Magnetic polymer microspheres are made of inorganic Fe 3 o 4 It is composed of magnetic materials such as magnetic materials and organic polymers, and its functional diversity and ease of control have attracted widespread attention. This type of functional material has the properties of a polymer material, and its functionality can be easily adjusted through the selection of polymerized monomers, such as hydrophilicity, hydrophobicity, and biocompatibility; and the reactive functional groups on the surface can Combined with biologically active molecules, it has broad application prospects in immobilized enzymes, cell separation and targeted drugs. [0003] At present, the methods for preparing polymer magnetic microspheres mainly include polym...

Claims

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Application Information

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IPC IPC(8): H01F1/42B01J13/02
Inventor 薛屏邢明顺王居兰梁莹莹罗发亮
Owner NINGXIA UNIVERSITY
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