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Method for preparing monodisperse mesoporous bioactive glass microspheres by template method

A bioactive glass, monodisperse technology, applied in glass molding, glass manufacturing equipment, manufacturing tools, etc., can solve the problems that are not suitable for the preparation of MBGs microspheres, and achieve comprehensive excellent comprehensive performance, high thermal stability and comprehensive performance excellent effect

Active Publication Date: 2015-12-02
扬州智创企业运营管理服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used methods for preparing mesoporous silica microspheres are often not suitable for preparing MBGs microspheres

Method used

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  • Method for preparing monodisperse mesoporous bioactive glass microspheres by template method
  • Method for preparing monodisperse mesoporous bioactive glass microspheres by template method
  • Method for preparing monodisperse mesoporous bioactive glass microspheres by template method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Preparation of 75S25C mesoporous bioactive glass microspheres (M75S25C) with different particle sizes:

[0041] (1) Add 1.8g of non-polar triblock copolymer PluronicF127 (hereinafter referred to as F127) into a mixture of 0.04g of nitric acid solution (2mol / L), 0.1g of deionized water and 4g of absolute ethanol, and stir to obtain Clear mixed solution.

[0042] (2) Add 0.59 g of calcium nitrate tetrahydrate to the above mixed solution, and stir until completely dissolved.

[0043] (3) 1.56g of tetraethyl orthosilicate was added, and stirring was continued for 2h.

[0044] 1) Mix mineral acid with deionized water and absolute ethanol, add surfactant, and stir to obtain a clear mixed solution;

[0045] 2) Add alkali metal or alkaline earth metal source, calcium source and iron source to the above mixture, stir until completely dissolved, then add silicon source and phosphorus source, and continue stirring;

[0046] The silicon source is tetraethyl orthosilicate (TEO...

Embodiment 2

[0055] 1. Preparation of 70S7F magnetic mesoporous bioactive glass microspheres (MM70S7F) with different particle sizes:

[0056] (1) Add 1.8g F127 to the mixed solution of 0.04g nitric acid solution (2mol / L) and 4g absolute ethanol, and stir until clear.

[0057] (2) Add 0.59g calcium nitrate tetrahydrate and 0.3g ferric nitrate nonahydrate, and stir until completely dissolved.

[0058] (3) 1.56g of tetraethyl orthosilicate was added, and stirring was continued for 2h.

[0059] (4) 4 copies of the above solution were prepared in parallel.

[0060] (5) Immerse in three-dimensional ordered macroporous polystyrene / carbon templates with pore diameters of 470 nm, 390 nm, 250 nm, and 180 nm, respectively, and soak overnight.

[0061] (6) Place in an oven at 60°C to gel the sol for 3 days until it is completely dry.

[0062] (7) Remove the excess gel on the surface of the template, calcined at 600 °C for 3 hours in a high temperature furnace, grind and ultrasonically disperse to ...

Embodiment example 3

[0088] Preparation and in vitro degradation experiments of 70S30C mesoporous bioactive glass microspheres (M70S30C) with different particle sizes:

[0089] Preparation of M70S30C:

[0090] (1) Add 1.8g of F127 into the mixture of 0.04g of nitric acid solution (2mol / L), 0.1g of deionized water and 4g of absolute ethanol, and stir until clear.

[0091] (2) Add 0.71g calcium nitrate tetrahydrate and stir until completely dissolved.

[0092] (3) Add 1.45g tetraethyl orthosilicate and continue stirring for 2h.

[0093] (4) Four copies of the above solution were prepared in parallel.

[0094] (5) Immerse three-dimensionally ordered macroporous polystyrene / carbon templates with pore diameters of 470nm, 390nm, 250nm, and 180nm respectively, and soak overnight.

[0095] (6) Place in an oven at 60°C, and gel the sol for 3 days until it is completely dry.

[0096] (7) Remove excess gel on the surface of the template, calcinate in a high-temperature furnace at 600°C for 3 hours, grind...

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Abstract

The invention relates to a method for preparing monodisperse mesoporous bioactive glass microspheres through a template method, belonging to the field of biomedical materials. A silicon source, a phosphorus source, a calcium source, an iron source, an alkali metal or alkaline-earth metal source is adopted as a raw material, a triblock copolymer or alkyl quaternary ammonium salt type cation is taken as a surfactant, and an in-situ sol-gel method is performed in a three-dimensional ordered macroporous polymer or a carbon template to synthesize the ordered mesoporous bioactive glass microspheres. The bioactive glass microspheres prepared according to the invention have the characteristics of good biocompatibility, biodegradability, ordered mesoporous structure, higher specific surface area, magnetism, monodispersibility of particles, environmental stability and the like; and in comparison with various medicament delivery carrier materials which are extensively researched currently, the bioactive glass microspheres have more comprehensive advantages and further have broad application prospects as novel medicament controlled release carrier materials.

Description

technical field [0001] The invention relates to products and methods in the field of biomedical materials, in particular to monodisperse mesoporous bioactive glass microspheres (MBGs) and a preparation method thereof. Background technique [0002] Bioactive glass is a third-generation biomaterial invented by Professor Larry L Hench and others in 1971, mainly including SiO 2 -CaO-P 2 o 5 System and SiO 2 -CaO system, partially containing Na 2 O, K 2 O, MgO, Al 2 o 3 , B 2 o 3 、TiO 2 , Ag, etc. Bioactive glass materials have good biocompatibility, biodegradability, excellent osteoinductive ability, and no toxic side effects. At present, they are mainly used in the fields of dentistry, orthopedics, bone defect repair, and soft tissue injury healing, and as medical devices. It is gradually being put into use all over the world, and its safety and clinical effectiveness have been approved by the US FDA, the European Community and China's State Drug Administration. It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03B19/12A61K47/04A61L27/10A61L27/56
Inventor 纪立军司云凤
Owner 扬州智创企业运营管理服务有限公司
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