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Liquiritigenin oral preparation, injection preparation and preparation method thereof

Technology of an oral preparation, Liquiritigenin, applied in the field of medicine

Inactive Publication Date: 2013-09-25
NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]Although there have been reports on the antitumor effect and mechanism of liquiritigenin, so far, liquiritigenin only exists as licorice extract, Reports on tumor preparations, their clinical efficacy and application have been blank

Method used

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  • Liquiritigenin oral preparation, injection preparation and preparation method thereof
  • Liquiritigenin oral preparation, injection preparation and preparation method thereof
  • Liquiritigenin oral preparation, injection preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] As described in Example 1, the difference is that the obtained glycyrrhizin granules are compressed into tablets containing 0.025g of liquiritigenin per tablet.

[0024] Embodiment 3 Glycyrrhizin Capsules

Embodiment 2

[0025] As described in Example 1, the difference is that the obtained glycyrrhizin granules are packed into hard capsule shells to obtain glycyrrhizin capsules by containing 0.025g of liquiritigen per capsule.

[0026] Embodiment 4 Liquiritigenin Soft Capsules

Embodiment 3

[0027] .Take 10g of Liquiritigenin and pass through a 120 mesh sieve, add 80g of polysorbate 80, 80g of polyethylene glycol 400, 10g of 1,2-propylene glycol, and 10g of water into the mixed solution of the obtained powder, grind for 60min, and make all pass through a 120 mesh sieve, Leave it to stand overnight, measure the content of liquiritigenin in the medicinal solution (the content of liquiritigenin in 1g of medicinal solution is 55.6mg); place the medicinal solution in the liquid storage tank of the capsule rolling machine, heat the capsule at 48°C, and press the capsule with 80g of gelatin slurry, the weight ratio is dry gelatin: glycerin: water=1:0.5:1. Dry in cold air for 24 hours, wash with absolute ethanol, dry, and select capsules to obtain liquiritigenin soft capsules.

[0028] Embodiment 5 Glycyrrhizin Dropping Pills

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Abstract

The invention relates to anticancer liquiritigenin oral preparation and injection preparation, and a preparation method thereof, belonging to a medical technology field. The oral preparation comprises a particulate agent, tablets, capsules, pills and softgel, and the injection preparation comprises small hydro-acupuncture, freeze-dried powder injection, glucose injection and sodium chloride injection. The liquiritigenin oral preparation contains 0.1-100g liquiritigenin per 1000 preparation unit, and the injection preparation contains 0.1-100g liquiritigenin per 1000mL. Pharmaceutic adjuvants contain a diluent, a wetting agent, a disintegrating agent, a flow aid, a cosolvent, an excipient and an osmotic pressure regulator. The liquiritigenin preparation provided by the invention is safe and reliable, and has functions for preventing and treating cancers. And the anticancer medicament is used for preventing and treating lung cancer, liver cancer, stomach cancer, colorectal carcinoma, leukemia, etc., and is a new and effective anticancer medicine.

Description

technical field [0001] The invention relates to an oral and injection preparation with liquiritigenin as an active ingredient and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Malignant tumor is one of the diseases that seriously threaten human health and life. It has the characteristics of long treatment course, difficult to cure, and heavy economic and mental burden, which brings a heavy burden to patients and society. Since the 1970s, the incidence of cancer in my country has been on the rise. The annual number of cancer cases is about 2 million, and the number of cancer deaths exceeds 1.4 million. Among them, the high incidence of liver cancer is very serious, and the mortality rate ranks third in cancer mortality. Every year, 110,000 people die from liver cancer, accounting for about 45% of the total number of deaths from liver cancer in the world. In this regard, the cancers that my country proposes to focus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/16A61K9/20A61K9/48A61K9/08A61K9/19A61P35/00
Inventor 蔡宝昌蔡云清顾杰姚仲青秦昆明李嬛段煜张淼
Owner NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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