Moxifloxacin capsules, and preparation method thereof
A technology of moxifloxacin hydrochloride and capsules, applied in the field of medicine, can solve problems such as inability to be equivalent, slow dissolution and the like
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[0022] Adopt the embodiment 2 of patent CN200510021739.1 to prepare samples,
[0023] Prescription composition:
[0024]
[0025] Preparation method: Take the raw materials and auxiliary materials in the above components, mix them well, make granules by dry method, and fill the hydroxypropyl cellulose capsule shell to get the product.
Embodiment 1
[0027] Prescription composition:
[0028]
[0029] Preparation:
[0030] ① Mix moxifloxacin hydrochloride and carboxymethyl starch sodium uniformly according to the method of equal volume addition, then mix with microcrystalline cellulose evenly, and take internally added magnesium stearate and mix evenly;
[0031] ②Start the dry granulator, adjust the distance between the rollers to 0.2 mm, the feeding speed to 72 revolutions / min, the speed of the pressing wheel to 2 revolutions / min, and the screen mesh to be 10-18 meshes, pour the above materials into the feeding hopper, and The material is received at the outlet.
[0032] ③Mix the dry granulated granules and magnesium stearate evenly, fill them into No. 0 gelatin capsules with capsule filler, and obtain the product.
Embodiment 2
[0034] Prescription composition:
[0035]
[0036]
[0037] Preparation:
[0038] Thoroughly mix moxifloxacin hydrochloride with auxiliary materials microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate to make granules by dry method, fill them in gelatin capsules, and obtain the product.
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