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A kind of preparation method of artificial ligament

An artificial ligament and ligament technology, applied in ligament, medical science, muscle and other directions, can solve the problems of lack of high polar groups, poor hydrophilicity and cytocompatibility, high crystallinity, and achieve increased biocompatibility, Inhibits bacterial infection and improves penetration

Active Publication Date: 2016-01-20
周婕
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the symmetrical molecular structure and high crystallinity of polyethylene terephthalate, there are only a small amount of hydrophilic groups such as hydroxyl groups in the structure, lack of high polar groups, and the hydrophilicity and cytocompatibility are relatively low. Poor, it is easy to cause foreign body reaction in the human body and cause inflammation. The more serious consequence of inflammation is that the artificial ligament must be removed, and the patient will suffer from the pain of a second operation.

Method used

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  • A kind of preparation method of artificial ligament
  • A kind of preparation method of artificial ligament
  • A kind of preparation method of artificial ligament

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preparation example Construction

[0034] The invention also discloses a method for preparing the artificial ligament, comprising the following steps:

[0035] (A) reacting the ligament of polyethylene terephthalate material with ozone to obtain polyethylene terephthalate with free radicals;

[0036] (B) Under the protection of an inert gas, the polyethylene terephthalate with free radicals in the solution containing monomer molecules is subjected to a closed polymerization reaction to obtain an artificial ligament;

[0037] The monomer molecules are sugar compounds or vinyl monomers containing hydrophilic groups.

[0038] In the present invention, the polyethylene terephthalate material ligament is used as a raw material, which is modified to obtain an artificial ligament with better biocompatibility. In the present invention, there is no special limitation on the source of the ligament of the polyethylene terephthalate material, which can be purchased from the market.

[0039] In the present invention, at f...

Embodiment 1

[0045] Add 20 grams of sodium styrene sulfonate to 100 ml of a mixed solution of water and ethanol, the volume ratio of water and ethanol is 1:9, heat at 70°C, filter the solution after the sodium styrene sulfonate dissolves, and place the filtrate at 4 degrees Refrigerate overnight, after the crystals are precipitated, filter and dry for later use.

[0046] Put the ligament of the PET material to be processed into 200ml of distilled water, open the oxygen bottle (0.6L / min), pass the ozone generator, and put the ozone (O 3 ) into distilled water and reacted for 10 minutes.

[0047] Make the recrystallized sodium styrene sulfonate crystals into a solution with a concentration of 15% by mass, pass in argon to drive out the oxygen in the solution, add ozonated PET material and directly seal the polymerization reaction at 70°C for one Hours, get the artificial ligament.

[0048] The obtained artificial ligament was determined by colorimetry. The artificial ligament was co-cultur...

Embodiment 2

[0054] Add 20 grams of sodium styrene sulfonate to 100 ml of a mixed solution of water and ethanol, the volume ratio of water and ethanol is 1:9, heat at 70°C, filter the solution after the sodium styrene sulfonate dissolves, and place the filtrate at 4 degrees Refrigerate overnight, after the crystals are precipitated, filter and dry for later use.

[0055] Put the artificial ligament of PET material that needs to be processed into 200ml of distilled water, open the oxygen bottle (0.6L / min), and pass the ozone generator (O 3 ) into distilled water and reacted for 10 minutes.

[0056] The recrystallized sodium styrene sulfonate crystals were made into a solution with a concentration of 15% by mass, and argon gas was introduced to drive out the oxygen in the solution, and the ozonated PET material was added to directly seal the polymerization reaction at 70°C for 3 times Hours, get the artificial ligament.

[0057] X-ray photoelectron spectroscopy (XPS) was performed on the o...

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Abstract

The invention provides an artificial ligament which comprises an inner core and an outer layer from inside to outside in sequence. The inner core is made of ozonized polyethylene glycol terephthalate, and the outer layer is made of polysaccharide or polymer polymerized from hydrophilic group contained allyl monomer and is grafted on a free radical locus of the inner core. A preparation method of the artificial ligament includes: subjecting a ligament of a polyethylene glycol terephthalate material to reaction with ozone so as to obtain the polyethylene glycol terephthalate with a free radical; under protection of inert gas, subjecting a solution containing monomer molecules and the polyethylene glycol terephthalate containing the free radical to sealed polymerization reaction so as to obtain the artificial ligament. The artificial ligament is good in biocompatibility, and capable of restraining bacterial infection, changing protein conformation adhered on surface of a material, reducing inflammation and promoting adhering, growing and fibroblast of fibroblast after being planted in a human body. Collagen protein synthesis on the surface of the artificial ligament is improved, and infiltration of new ligament tissue is facilitated.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to an artificial ligament and a preparation method thereof. Background technique [0002] The rupture of the anterior and posterior cruciate ligaments of the knee joint is a common knee joint injury, usually caused by severe knee joint twisting. Improper treatment can lead to instability of the knee joint, causing secondary damage to the knee joint and premature degeneration of the joint, thereby affect joint performance. In current cruciate ligament reconstruction treatments, artificial ligaments are increasingly used. Among them, the LARS artificial ligament was developed by the French Laboureau company and began to be used clinically in 1992. LARS artificial ligament is the only artificial ligament product that has passed the tension-torsion-buckling test in Europe, and its material is polyethylene terephthalate. Since the first LARS artificial ligament was successfully used in Sha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/08A61L27/20A61L27/16A61L27/18A61L27/54C08F283/02
Inventor 周婕
Owner 周婕
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