Process for synthesizing 2, 3, 3, 3-tetrafluoropropionic acid

Abstract

The invention relates to a chemical synthesis process, and particularly relates to a process for synthesizing 2, 3, 3, 3-tetrafluoropropionic acid. According to the process, N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide as the starting material is subjected to a hydrolysis reaction under the acidic condition by using a catalyst; the side product N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide obtained by the fluorine substitution reaction of N, N-diethyl-1, 1, 2, 3, 3, 3-tetrafluoropropionamide is effectively utilized to obtain high-purity 2, 3, 3, 3-tetrafluoropropionic acid through the simple, easily-operated and easy separation and extraction process, the addition of the catalyst greatly accelerates the reaction speed and improves the product yield which reaches 96 percent, the benefit is built, the waste liquid treatment cost is reduced, and the environment is protected; the raw materials in the invention are low in price and easily obtained, the reaction conditions are mild, the reaction is speedy, the process is simple, easily operated and easily treated; and the process is beneficial for achievement of industrialization.

Description

[0001] technical field [0002] The invention relates to a chemical synthesis method, in particular to a synthesis method of 2,3,3,3-tetrafluoropropionic acid. Background technique [0003] 2,3,3,3-Tetrafluoropropionic acid is a valuable pharmaceutical and pesticide intermediate, CAS number: 359-49-9, and its molecular structure is as follows: [0004] [0005] At present, the main synthesis route of 2,3,3,3-tetrafluoropropionic acid is fluorine substitution by propionic acid. The disadvantage of this process is that the reaction is difficult to control, the by-products are many impurities, and it is not easy to purify, so the yield is not high. [0006] N,N-diethyl-2,3,3,3-tetrafluoropropionamide is N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine after fluorine substitution reaction The by-products are difficult to degrade, which greatly increases the difficulty and cost of factory waste liquid treatment, and if it is not handled properly, it will cause great pollution to...

AI Technical Summary

Problems solved by technology

[0005] At present, the main synthesis route of 2,3,3,3-tetrafluoropropionic acid is to replace propionic acid with fluorine. The disadvantage of this process is that the reaction is difficult to control, the by-products are many impurities, and it is not easy to purify, so the yield is not high.

[0006] N,N-diethyl-2,3,3,3-tetrafluoropropionamide is N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine after fluorine substitution reaction The by-products are difficult to degrade, which greatly increases the difficulty and cost of factory waste liquid treatment. If the treatment is not good, it will cause great pollution to the environment.

At present, N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine is widely used as a fluorinating reagent in industry to participate in various fluorination reactions, while producing a large amount of by-products N,N -Diethyl-2,3,3,3-tetrafluoropropionamide, these by-products have caused great pressure on the production enterprises and the environment