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Methods and compositions useful for promoting sleep in animals

A technology of animal sleep and composition, applied in the directions of drug combination, botanical equipment and method, animal repellent, etc., can solve problems such as unclear

Inactive Publication Date: 2013-07-31
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such benefits have not been established in animals such as cats and dogs
Therefore, it is unclear whether purified melatonin has the same benefits in pets as it does in humans

Method used

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  • Methods and compositions useful for promoting sleep in animals
  • Methods and compositions useful for promoting sleep in animals
  • Methods and compositions useful for promoting sleep in animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] After collecting baseline data for all animals, 48 ​​dogs at least 9 years old were divided into treatment and control groups. Each group included 24 animals. The animals were fed either: (1) a control diet containing 28% crude protein, 12% crude fat, 3% crude fiber, and 181 ppm zinc, or (2) a treatment diet containing 28% crude protein, 12% crude fat and 3% crude fiber and 13.5ppm melatonin, 8.2ppm astaxanthin and 208ppm zinc. The amount of melatonin is based on a dose of about 0.1 mg / kg / bw.

[0066] Animals were given control or treatment chow for 77 days. All animals were fed twice a day at 9AM (±30 minutes) and 6PM (±30 minutes). Animals in the treatment group were fed control chow at breakfast and treatment chow at afternoon meal. Animals assigned to the control group were fed twice a day at 9 AM (±30 minutes) and 6 PM (±30 minutes), respectively, and were fed control chow in both AM and PM.

Embodiment 2

[0068] Using a crossover design, all animals were given either a control placebo or a therapeutic supplement containing melatonin. The animals are senior animals (senior animals), and the age of the dogs is more than 10 years. There were 4 males and 4 females in each group. During the intervention phases (Phase 2 and 4), all animals were given melatonin either AM or PM. During the control and crossover phases (phases 1 and 3, respectively), animals were given placebo containing methylcellulose contained in gel capsules in the AM or PM, as appropriate.

[0069] Each phase lasts 35 days. Starting from the 29th day of each stage, the animals' autonomous behavior activities were monitored for 4 consecutive days.

[0070] The placebo consisted of a carrier (methylcellulose) contained in a gel capsule, which was administered during the control phase (phases 1 and 3) at AM or PM feeding, with supplementation as appropriate during the next intervention phase. For example, a placeb...

Embodiment 3

[0076] After collecting baseline data for all animals, 48 ​​dogs at least 9 years old were divided into treatment and control groups. Each group included 24 animals. Animals were fed either: (1) a control diet containing 26% crude protein, 16% crude fat, and 3% crude fiber, or (2) a treatment diet containing 26% crude protein, 16% crude Fat and 3% crude fiber and 130ppm melatonin. The amount of melatonin was based on a dose of 0.1 mg / kg / bw. Animals were given control or treatment chow for 77 days. All animals were fed twice a day at 9AM (±30 minutes) and 6PM (±30 minutes). Animals in the control and treatment groups differed only in whether they were supplemented with placebo or melatonin.

[0077] Process and data logging

[0078] A. Activity record

[0079] Using the Actiwatch method ( Activity Monitoring System, Respironics Co., Inc., Bend, OR), for 5 consecutive days and 5 nights for Example 1 and 3 consecutive days and 4 nights for Example 2, to evaluate 24-hou...

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Abstract

Methods and compositions for promoting sleep in an animal are provided. In a general aspect, a sleep promoting amount of astaxanthin and a sleep promoting amount of melatonin are administered in conjunction to an animal. The astaxanthin can be administered in an amount ranging from about 0.1 to about 60 mg / kg / body weight of the animal. The melatonin can be administered in an amount ranging from about U. I to about 40 mg / kg / body weight of the animal. The method can further comprise administering in conjunction a sleep promoting amount of zinc to the animal. The zinc can be administered in an amount ranging from about 10 to about 100 mg / kg / body weight of the animal.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application Serial No. 61 / 459181, filed December 7, 2010, the contents of which are incorporated herein by reference. technical field [0003] The present invention generally relates to methods and compositions for improving sleep, especially the use of astaxanthin and melatonin for improving sleep in animals. Background technique [0004] The sleep-wake cycle in animals is the most easily observed circadian rhythm and is an indispensable function for healthy living. Normal aging is often accompanied by an increased incidence of sleep disturbances and a decrease in sleep quality. Up to 80% of older adults have difficulty falling asleep with increased nighttime awakenings, early awakenings and / or daytime naps. Likewise, in canines, aging is associated with changes in sleep patterns and decreased activity levels, which are often reported by pet owners and observed unde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/38
CPCA61K31/4045A01N43/38A61K31/405C07D209/04A61K33/30A61K31/122A61P25/04A61P25/20A61P43/00A61K2300/00
Inventor B·M·赞吉
Owner NESTEC SA
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