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Method for preparing carbon nanotube composite conductive hydrogel coating modified electrode

A carbon nanotube composite, conductive hydrogel technology, applied in the field of biomedical materials and medical devices

Inactive Publication Date: 2013-07-10
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to propose a method for preparing carbon nanotube composite conductive hydrogel coating on the metal electrode surface, the coating prepared by the method has excellent It has excellent electrochemical catalytic activity and good biocompatibility, which overcomes the shortcomings of traditional metal electrodes / biological interface, such as poor compatibility, easy inflammation and electrode failure, and can be used on the electrode surface of bioelectrochemical sensors to improve the sensor's performance. sensitivity

Method used

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  • Method for preparing carbon nanotube composite conductive hydrogel coating modified electrode
  • Method for preparing carbon nanotube composite conductive hydrogel coating modified electrode

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Step 1, preparation of carbon nanotube dispersion liquid.

[0040] Take 500 mg of multi-walled carbon nanotubes into 200 mL of 30% H 2 o 2 The solution was sonicated for 30 min, and then refluxed at 60 °C for 1 h. The resulting solution was vacuum filtered through a 0.2 μm polyvinylidene fluoride membrane. Wash the filtered carbon nanotubes with deionized water until neutral, and then put them into a vacuum drying oven for drying. Add the dried carbon tubes into 40 mL of mixed acid solution containing concentrated sulfuric acid and concentrated nitric acid (vH 2 SO 4 : vHNO 3 =3:1) were subjected to magnetic stirring for 1 hour, and then ultrasonically dispersed at 60 °C for 4 hours. The resulting dispersion is centrifuged to remove excess acid, and the centrifuged carbon nanotubes are washed with a large amount of deionized water until neutral. Finally, vacuum-dry at 80°C to obtain the required acidified carbon tubes.

[0041] Take 20 mg of acidified carbon nan...

Embodiment 2

[0051] Step 1, preparation of carbon nanotube dispersion liquid.

[0052] Weigh 40 mg of anionic surfactant sodium dodecylbenzene sulfonate and dissolve it in 30 mL of deionized water, and make it fully dissolved by magnetic stirring. After the dissolution is complete, 30 mg of carbon nanotube solid powder is slowly added while continuing magnetic stirring, so that the carbon nanotubes are fully dispersed in the surfactant solution. After magnetic stirring for 40 minutes, ultrasonic dispersion was used for 3 hours to obtain a uniform and stable carbon nanotube dispersion.

[0053] Step 2, preparation of carbon nanotube / hyaluronic acid composite sol.

[0054] Accurately weigh 3 g of hyaluronic acid, add 100 g of deionized water and stir with a magnetic stirrer to fully dissolve the solute hyaluronic acid at 80°C to obtain a hyaluronic acid sol with a concentration of 3%; continue magnetic stirring, The carbon nanotube dispersion was slowly added dropwise into the hyaluronic a...

Embodiment 3

[0061] Step 1, preparation of carbon nanotube dispersion liquid.

[0062] The carbon nanotubes were dispersed with the cationic surfactant cetyltrimethylammonium bromide. Weigh 40 mg of cetyltrimethylammonium bromide and dissolve it in 40 mL of deionized water, and make it fully dissolved by magnetic stirring. After the dissolution is complete, continue magnetic stirring while slowly adding 20 mg of carbon nanotube solid powder to fully disperse the carbon nanotubes in the surfactant solution. After magnetic stirring for 30 minutes, ultrasonic dispersion was used for 3 hours to obtain a uniform and stable carbon nanotube dispersion.

[0063] Step 2, preparation of carbon nanotube / sodium alginate composite sol.

[0064] Accurately weigh 2 g of sodium alginate, add 100 g of deionized water and stir with a magnetic stirrer to fully dissolve the solute sodium alginate at 80°C to obtain a sodium alginate sol with a concentration of 2%; continue magnetic stirring, and The carbon ...

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Abstract

The invention relates to the field related to biomedical materials and medical apparatuses and in particular relates to a method for preparing a carbon nanotube composite conductive hydrogel coating modified electrode by adopting an electrophoretic deposition method. The method comprises the following steps of: 1. preparing carbon nanotube dispersion liquid; 2. preparing a carbon nanotube composite polymer sol body; 3. pretreating a metal electrode; 4. preparing a composite conductive hydrogel coating through electrophoretic deposition; and 5. crosslinking the composite coating and finally forming the carbon nanotube composite conductive hydrogel coating modified electrode, wherein the prepared electrode is put in phosphate buffered solution for standby use. The method has the advantages that various carbon nanotube surface treatment methods and various sol-gel phase transformation or crosslinking methods are adopted, thus solving the problems that the carbon nanotube and the composite material thereof are difficult to disperse in the water solution systems, are easy to agglomerate and have potential biosafety risks and the like.

Description

technical field [0001] The invention relates to the related fields of biomedical materials and medical devices, in particular to a method for preparing a carbon nanotube composite conductive hydrogel coating modified electrode by using an electrophoretic deposition method. Background technique [0002] The essence of the life process is the transfer of charges, and this process needs to be realized through a certain interface. The chemical electrode can be regarded as an ideal platform for studying the structure and function of biomembranes, biomolecules or the charge transfer behavior between biomolecules. In recent years, the research and application of built-in biosensor electrodes and nerve repair electrodes have attracted great attention, and are widely used in the real-time detection and clinical monitoring of specific biomolecules in vivo, and the recovery stimulation of visual nerves and auditory nerves, etc., and these applications involve In vivo long-term implanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 郑裕东李伟林清华付晓利王鹏飞
Owner UNIV OF SCI & TECH BEIJING
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